Friday, July 10, 2026

Drug profile · INN

rolapitant hydrochloride

rolapitant hydrochloride (VARUBI) is a neurokinin 1 receptor antagonist. Route of administration: oral. Current US regulatory status: approved.

FDA: approved
US status approved
Patents linked 0
Pipeline programs 0
News articles 0
Drug details — rolapitant hydrochloride
US status
approved
Class
Route
ORAL
Patents
0
Programs
0
Data quality
0.84

Quick answer

rolapitant hydrochloride (VARUBI) is a neurokinin 1 receptor antagonist. Route of administration: oral. Current US regulatory status: approved.

Key facts

INN rolapitant hydrochloride
Brand VARUBI
Mechanism Neurokinin 1 receptor antagonist
Target Substance-P receptor
Route ORAL
Formulation EMULSION

Mechanism of action

Neurokinin 1 receptor antagonist

Primary target: Substance-P receptor

Approval history

Authority Status Date
FDA approved

Related & competitor drugs

  1. aprepitant Alimentary tract and metabolism (A04)
  2. fosaprepitant dimeglumine Neurokinin 1 receptor antagonist
  3. tradipitant Neurokinin 1 receptor antagonist
  4. elinzanetant Neurokinin 3 receptor antagonist
  5. fosnetupitant chloride hydrochloride Neurokinin 1 receptor antagonist
  6. netupitant Alimentary tract and metabolism (A04)

Frequently asked questions

What is rolapitant hydrochloride?

rolapitant hydrochloride (VARUBI) is a neurokinin 1 receptor antagonist. Route of administration: oral. Current US regulatory status: approved.

What is the brand name for rolapitant hydrochloride?

VARUBI is a marketed brand name for rolapitant hydrochloride. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of rolapitant hydrochloride?

rolapitant hydrochloride has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.