Wednesday, July 8, 2026

Drug profile · INN

aprepitant

aprepitant (APREPITANT APOTEX) is a neurokinin 1 receptor antagonist. Associated with Lacuna Pharma Pty Ltd. Route of administration: oral. Current US regulatory status: approved.

FDA: approved EMA: approved TGA: approved NMPA: clinical trials Alimentary tract and metabolism (A04) A04AD12
US status approved
Patents linked 20
Pipeline programs 13
News articles 0
Drug details — aprepitant
US status
approved
Class
Alimentary tract and metabolism (A04)
Route
ORAL
Patents
20
Programs
13
Data quality
0.89

Quick answer

aprepitant (APREPITANT APOTEX) is a neurokinin 1 receptor antagonist. Associated with Lacuna Pharma Pty Ltd. Route of administration: oral. Current US regulatory status: approved.

Key facts

INN aprepitant
Brand APREPITANT APOTEX
Mechanism Neurokinin 1 receptor antagonist
Target Substance-P receptor
Therapeutic class Alimentary tract and metabolism (A04)
Route ORAL
Formulation INJECTION, EMULSION
ATC code A04AD12

Mechanism of action

Neurokinin 1 receptor antagonist

Primary target: Substance-P receptor

Approval history

Authority Status Date
FDA approved
EMA approved
TGA approved
NMPA clinical trials

Pipeline programs

  1. Fosaprepitant Phase 3 · First People's Hospital · Multiple Myeloma
  2. IVEMEND for Delayed chemotherapy induced na… Phase 3 · AXIM Biotechnologies · Delayed chemotherapy induced nausea and vomiting (CINV)
  3. ALL3024 Phase 2 · Telethon Foundation · Very High-Risk T-Lineage Acute Lymphoblastic Leukemia (ALL)
  4. Aprepitant Phase 2 · BRIGHT MINDS BIOSCIENCES · Cannabis Dependence
  5. Aprepitant Phase 2 · GSK Glaxo Smith · Nausea and Vomiting
  6. Aprepitant injectable emulsion Phase 2 · Heron Therapeutics · COVID-19
  7. J2R-MC-YAAD Phase 2 · Eli Lilly and · Nausea, Drug-Related Side Effects and Adverse Reactions, Vom
  8. MK-3475-B98 Phase 2 · MSD Merck Sharp · Participants with extensive-stage small cell lung cancer

Related & competitor drugs

  1. agalsidase alfa Alimentary tract and metabolism (A16)
  2. alogliptin Alimentary tract and metabolism (A10)
  3. alogliptin benzoate Alimentary tract and metabolism (A10)
  4. budesonide Alimentary tract and metabolism (A07)
  5. canagliflozin Alimentary tract and metabolism (A10)
  6. cerliponase alfa Alimentary tract and metabolism (A16)
  1. US 12331040

    Substituted benzofuranyl and benzoxazolyl compounds and uses thereof

    Expires Mon Jun 12 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 12290520

    Methods of use of emulsion formulations of aprepitant

    Expires Mon May 01 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 12144815

    Use of aprepitant for treating Alzheimer's disease

    Expires Mon Nov 14 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 12115254

    Methods of use of emulsion formulations of an NK-1 receptor antagonist

    Expires Mon Oct 10 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 12115255

    Methods of use of emulsion formulations of an NK-1 receptor antagonist

    Expires Mon Oct 10 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 11878074

    Methods of use of emulsion formulations of an NK-1 receptor antagonist

    Expires Mon Jan 18 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 11744800

    Methods of use of emulsion formulations of an NK-1 receptor antagonist

    Expires Mon Aug 31 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 11173118

    Emulsion formulations of an NK-1 receptor antagonist and uses thereof

    Expires Mon Nov 11 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 11008309

    Substituted benzofuranyl and benzoxazolyl compounds and uses thereof

    Expires Mon May 13 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 10953018

    Emulsion formulations of aprepitant

    Expires Mon Mar 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 10858347

    Multicyclic compounds and uses thereof

    Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 10624850

    Emulsion formulations of an NK-1 receptor antagonist and uses thereof

    Expires Mon Apr 16 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 10500208

    Emulsion formulations of aprepitant

    Expires Mon Dec 05 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 10399963

    Substituted benzofuranyl and benzoxazolyl compounds and uses thereof

    Expires Mon Aug 29 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 9994558

    Multicyclic compounds and methods of using same

    Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 9974793

    Emulsion formulations of aprepitant

    Expires Mon May 17 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 9974742

    Emulsion formulations of an NK-1 receptor antagonist and uses thereof

    Expires Mon May 17 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 9974794

    Emulsion formulations of aprepitant

    Expires Mon May 17 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 9938258

    Substituted 2,3-dihydrobenzofuranyl compounds and uses thereof

    Expires Mon Apr 05 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 9856241

    Substituted benzofuranyl and benzoxazolyl compounds and uses thereof

    Expires Mon Dec 28 2037 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is aprepitant?

aprepitant (APREPITANT APOTEX) is a neurokinin 1 receptor antagonist. Associated with Lacuna Pharma Pty Ltd. Route of administration: oral. Current US regulatory status: approved.

What is the brand name for aprepitant?

APREPITANT APOTEX is a marketed brand name for aprepitant. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of aprepitant?

aprepitant has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.