Friday, July 10, 2026

Drug profile · INN

riociguat

riociguat (ADEMPAS) is a soluble guanylate cyclase positive allosteric modulator. Associated with Bayer Australia Ltd. Route of administration: oral. Current US regulatory status: approved.

FDA: approved EMA: approved TGA: approved PMDA: approved Cardiovascular system (C02) C02KX05
US status approved
Patents linked 0
Pipeline programs 2
News articles 0
Drug details — riociguat
US status
approved
Class
Cardiovascular system (C02)
Route
ORAL
Patents
0
Programs
2
Data quality
0.89

Quick answer

riociguat (ADEMPAS) is a soluble guanylate cyclase positive allosteric modulator. Associated with Bayer Australia Ltd. Route of administration: oral. Current US regulatory status: approved.

Key facts

INN riociguat
Brand ADEMPAS
Mechanism Soluble guanylate cyclase positive allosteric modulator
Target Soluble guanylate cyclase
Therapeutic class Cardiovascular system (C02)
Route ORAL
Formulation TABLET
ATC code C02KX05

Mechanism of action

Soluble guanylate cyclase positive allosteric modulator

Primary target: Soluble guanylate cyclase

Approval history

Authority Status Date
FDA approved
EMA approved
TGA approved
PMDA approved

Pipeline programs

  1. Riociguat Phase 3 · Chinese Academy of · Chronic Thromboembolic Pulmonary Hypertension
  2. 14308 Phase 2 · Bayer · Patients symptomatic with pulmonary hypertension associated

Related & competitor drugs

  1. alirocumab Cardiovascular system (C10)
  2. aliskiren Cardiovascular system (C09)
  3. azilsartan medoxomil Cardiovascular system (C09)
  4. bempedoic acid Cardiovascular system (C10)
  5. bosentan Cardiovascular system (C02)
  6. dofetilide Cardiovascular system (C01)

Frequently asked questions

What is riociguat?

riociguat (ADEMPAS) is a soluble guanylate cyclase positive allosteric modulator. Associated with Bayer Australia Ltd. Route of administration: oral. Current US regulatory status: approved.

What is the brand name for riociguat?

ADEMPAS is a marketed brand name for riociguat. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of riociguat?

riociguat has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.