Wednesday, July 8, 2026

Drug profile · INN

prochlorperazine

prochlorperazine (APO-PROCHLORPERAZINE) is a dopamine d2 receptor antagonist. Associated with Alphapharm Pty Ltd. Route of administration: rectal. Current US regulatory status: approved.

FDA: approved TGA: approved
US status approved
Patents linked 4
Pipeline programs 2
News articles 0
Drug details — prochlorperazine
US status
approved
Class
Route
RECTAL
Patents
4
Programs
2
Data quality
0.84

Quick answer

prochlorperazine (APO-PROCHLORPERAZINE) is a dopamine d2 receptor antagonist. Associated with Alphapharm Pty Ltd. Route of administration: rectal. Current US regulatory status: approved.

Key facts

INN prochlorperazine
Brand APO-PROCHLORPERAZINE
Mechanism Dopamine D2 receptor antagonist
Target D(2) dopamine receptor
Route RECTAL
Formulation SUPPOSITORY

Mechanism of action

Dopamine D2 receptor antagonist

Primary target: D(2) dopamine receptor

Approval history

Authority Status Date
FDA approved
TGA approved

Pipeline programs

  1. casirivimab+imdevimab Phase 3 · Regeneron UK · Immunocompromised
  2. MATRIx Phase 2 · Telethon Foundation · Traumatic Brain Injury

Related & competitor drugs

  1. aripiprazole Nervous system (N05)
  2. brexpiprazole Nervous system (N05)
  3. cabergoline Dopamine D2 receptor agonist
  4. clozapine Serotonin 2a (5-HT2a) receptor antagonist
  5. fluphenazine decanoate Dopamine D2 receptor antagonist
  6. fluphenazine hydrochloride Dopamine D2 receptor antagonist
  1. US 10369208

    Methods for the induction of immune responses in a subject compromising administering virus-like particles (VLPS) prepared from Chikungunya virus structural proteins

    Expires Mon Aug 01 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 9044419

    Vaccine compositions compromising βs-crystallin for inducing immune responses against components of drusen

    Expires Mon May 28 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 8263091

    Method of treating and preventing infections in immunocompromised subjects with immunostimulatory CpG oligonucleotides

    Expires Mon Sep 06 2032 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 6444872

    Large animal model of invasive pulmonary aspergillosis in an immunocompromised host

    Expires Mon Aug 29 2022 00:00:00 GMT+0000 (Coordinated Universal Time)

    expired

Frequently asked questions

What is prochlorperazine?

prochlorperazine (APO-PROCHLORPERAZINE) is a dopamine d2 receptor antagonist. Associated with Alphapharm Pty Ltd. Route of administration: rectal. Current US regulatory status: approved.

What is the brand name for prochlorperazine?

APO-PROCHLORPERAZINE is a marketed brand name for prochlorperazine. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of prochlorperazine?

prochlorperazine has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.