Wednesday, July 8, 2026

Drug profile · INN

clozapine

clozapine (CLOPINE 100) is a serotonin 2a (5-ht2a) receptor antagonist. Associated with Lacuna Pharma Pty Ltd. Route of administration: oral. Current US regulatory status: approved.

FDA: approved TGA: approved PMDA: approved NMPA: clinical trials
US status approved
Patents linked 0
Pipeline programs 3
News articles 0
Drug details — clozapine
US status
approved
Class
Route
ORAL
Patents
0
Programs
3
Data quality
0.89

Quick answer

clozapine (CLOPINE 100) is a serotonin 2a (5-ht2a) receptor antagonist. Associated with Lacuna Pharma Pty Ltd. Route of administration: oral. Current US regulatory status: approved.

Key facts

INN clozapine
Brand CLOPINE 100
Mechanism Serotonin 2a (5-HT2a) receptor antagonist
Target D(2) dopamine receptor
Route ORAL
Formulation TABLET, ORALLY DISINTEGRATING

Mechanism of action

Serotonin 2a (5-HT2a) receptor antagonist

Primary target: D(2) dopamine receptor

Approval history

Authority Status Date
FDA approved
TGA approved
PMDA approved
NMPA clinical trials

Pipeline programs

  1. Clozapine Approved · BRIGHT MINDS BIOSCIENCES · Schizophrenia
  2. INTENSIFY SZ Approved · Disc Medicine · schizophrenia, schizoaffective disorder, schizophrenifom dis
  3. NL6220204217 Approved · Disc Medicine · HAMLETT compares regular treatment guidelines for patients i

Related & competitor drugs

  1. aripiprazole Nervous system (N05)
  2. brexpiprazole Nervous system (N05)
  3. cabergoline Dopamine D2 receptor agonist
  4. fluphenazine decanoate Dopamine D2 receptor antagonist
  5. fluphenazine hydrochloride Dopamine D2 receptor antagonist
  6. iloperidone Nervous system (N05)

Frequently asked questions

What is clozapine?

clozapine (CLOPINE 100) is a serotonin 2a (5-ht2a) receptor antagonist. Associated with Lacuna Pharma Pty Ltd. Route of administration: oral. Current US regulatory status: approved.

What is the brand name for clozapine?

CLOPINE 100 is a marketed brand name for clozapine. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of clozapine?

clozapine has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.