Wednesday, July 8, 2026

Drug profile · INN

evolocumab

evolocumab (REPATHA) is a subtilisin/kexin type 9 inhibitor. Associated with Amgen. Route of administration: injection. Current US regulatory status: approved.

FDA: approved EMA: approved TGA: approved PMDA: approved NMPA: clinical trials Cardiovascular system (C10) C10AX13
US status approved
Patents linked 0
Pipeline programs 10
News articles 2
Drug details — evolocumab

Quick answer

evolocumab (REPATHA) is a subtilisin/kexin type 9 inhibitor. Associated with Amgen. Route of administration: injection. Current US regulatory status: approved.

Key facts

INN evolocumab
Brand REPATHA
Mechanism Subtilisin/kexin type 9 inhibitor
Target Proprotein convertase subtilisin/kexin type 9
Therapeutic class Cardiovascular system (C10)
Route INJECTION
Formulation INJECTABLE
ATC code C10AX13
Originator Amgen

Mechanism of action

Subtilisin/kexin type 9 inhibitor

Primary target: Proprotein convertase subtilisin/kexin type 9

Approval history

Authority Status Date
FDA approved
EMA approved
TGA approved
PMDA approved
NMPA clinical trials

Recent coverage

Pipeline programs

  1. Evolocumab Phase 3 · Amgen · Coronary Heart Disease (CHD)
  2. Evolocumab Phase 3 · Amgen · Severe Familial Hypercholesterolemia
  3. Evolocumab Phase 3 · Amgen · Dyslipidemia
  4. Evolocumab Phase 3 · Amgen · Hyperlipidemia
  5. Evolocumab Phase 3 · COLLEGIUM PHARMACEUTICAL · Sars-CoV-2 Infection
  6. Placebo for AMG 145, EVOLOCUMAB Phase 3 · Amgen · Adults at high risk of cardiovascular events without prior M
  7. Evolocumab Phase 1 · BRIGHT MINDS BIOSCIENCES · Healthy Subjects
  8. EVOLOCUMAB Approved · Amgen · Dyslipidemia

Related & competitor drugs

  1. alirocumab Cardiovascular system (C10)
  2. aliskiren Cardiovascular system (C09)
  3. azilsartan medoxomil Cardiovascular system (C09)
  4. bempedoic acid Cardiovascular system (C10)
  5. bosentan Cardiovascular system (C02)
  6. dofetilide Cardiovascular system (C01)

Frequently asked questions

What is evolocumab?

evolocumab (REPATHA) is a subtilisin/kexin type 9 inhibitor. Associated with Amgen. Route of administration: injection. Current US regulatory status: approved.

What is the brand name for evolocumab?

REPATHA is a marketed brand name for evolocumab. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of evolocumab?

evolocumab has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.