Wednesday, July 8, 2026

Drug profile · INN

estradiol

estradiol (ESTRADERM MX 50) is a estrogen receptor alpha agonist. Associated with NovoThirteen. Route of administration: topical. Current US regulatory status: approved.

FDA: approved TGA: approved NMPA: clinical trials
US status approved
Patents linked 20
Pipeline programs 37
News articles 0
Drug details — estradiol
US status
approved
Class
Route
TOPICAL
Patents
20
Programs
37
Data quality
0.89

Quick answer

estradiol (ESTRADERM MX 50) is a estrogen receptor alpha agonist. Associated with NovoThirteen. Route of administration: topical. Current US regulatory status: approved.

Key facts

INN estradiol
Brand ESTRADERM MX 50
Mechanism Estrogen receptor alpha agonist
Target Estrogen receptor
Route TOPICAL
Formulation CAPSULE
Originator NovoThirteen

Mechanism of action

Estrogen receptor alpha agonist

Primary target: Estrogen receptor

Approval history

Authority Status Date
FDA approved
TGA approved
NMPA clinical trials

Pipeline programs

  1. 91781 Phase 3 · Bayer HealthCare Animal · Primary Dysmenorrhea
  2. Active Phase 3 · Aclaris Therapeutics · Common Wart
  3. Estradiol Phase 3 · TherapeuticsMD · Vulvovaginal Atrophy
  4. Estradiol Phase 3 · TherapeuticsMD · Menopause
  5. Estradiol Phase 3 · Teva Pharma · Dyspareunia
  6. Estradiol Vaginal Tablets 10 mcg Phase 3 · Amneal Pharma Europe · Atrophic Vaginitis Due to Menopause
  7. Generic Estradiol Vaginal Cream USP, 0.01% Phase 3 · Teva Pharma · Atrophic Vaginitis
  8. Levonorgestrel 100 mcg and Ethinyl Estradiol 20 mcg Phase 3 · Chinese Academy of · Oral Contraceptive

Related & competitor drugs

  1. estradiol valerate Estrogen receptor alpha agonist
  2. estrogens, conjugated synthetic a Estrogen receptor agonist
  3. estropipate Estrogen receptor alpha agonist
  4. ethinyl estradiol Estrogen receptor alpha agonist
  5. fulvestrant Antineoplastic and immunomodulating agents (L02)
  6. raloxifene Genito-urinary system and sex hormones (G03)
  1. US 12258354

    AhR modulators

    Expires Mon Mar 20 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 11957684

    Treatment of heavy menstrual bleeding associated with uterine fibroids

    Expires Mon Apr 11 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 11865179

    Progesterone formulations having a desirable PK profile

    Expires Mon Jan 04 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 11793819

    Natural combination hormone replacement formulations and therapies

    Expires Mon Oct 19 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 11793812

    Methods of treating endometriosis

    Expires Mon Oct 19 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 11622933

    Soluble estradiol capsule for vaginal insertion

    Expires Mon Apr 06 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 11584755

    Dihydrothieno[3,2-b]pyridine compounds

    Expires Mon Feb 16 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 11548867

    Amido compounds as AhR modulators

    Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 11529360

    Natural combination hormone replacement formulations and therapies

    Expires Mon Dec 15 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 11530220

    Substituted imidazo[1,5-a]pyrazines and [1,2,4]triazolo[4,3-a]pyrazines for the modulation of AhR

    Expires Mon Dec 15 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 11497709

    Vaginal inserted estradiol pharmaceutical compositions and methods

    Expires Mon Nov 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 11484591

    Chemoprevention using controlled-release formulations of anti-interleukin 6 agents, synthetic vitamin A analogues or metabolites, and estradiol metabolites

    Expires Mon Oct 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 11407764

    AhR modulators

    Expires Mon Aug 04 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 11351182

    Vaginal inserted estradiol pharmaceutical compositions and methods

    Expires Mon Jun 02 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 11304959

    Vaginal inserted estradiol pharmaceutical compositions and methods

    Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 11266661

    Vaginal inserted estradiol pharmaceutical compositions and methods

    Expires Mon Mar 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 11246875

    Vaginal inserted estradiol pharmaceutical compositions and methods

    Expires Mon Feb 10 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 11241445

    Vaginal inserted estradiol pharmaceutical compositions and methods

    Expires Mon Feb 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 11166963

    Natural combination hormone replacement formulations and therapies

    Expires Mon Nov 04 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 11123283

    Soluble estradiol capsule for vaginal insertion

    Expires Mon Sep 16 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is estradiol?

estradiol (ESTRADERM MX 50) is a estrogen receptor alpha agonist. Associated with NovoThirteen. Route of administration: topical. Current US regulatory status: approved.

What is the brand name for estradiol?

ESTRADERM MX 50 is a marketed brand name for estradiol. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of estradiol?

estradiol has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.