Wednesday, July 8, 2026

Drug profile · INN

iloperidone

iloperidone (FANAPTUM) is a dopamine d2 receptor antagonist. Associated with Vanda Pharmaceuticals Netherlands B.V.. Route of administration: oral. Current US regulatory status: approved.

FDA: approved EMA: unknown Nervous system (N05) N05AX14
US status approved
Patents linked 20
Pipeline programs 9
News articles 0
Drug details — iloperidone
US status
approved
Class
Nervous system (N05)
Route
ORAL
Patents
20
Programs
9
Data quality
0.89

Quick answer

iloperidone (FANAPTUM) is a dopamine d2 receptor antagonist. Associated with Vanda Pharmaceuticals Netherlands B.V.. Route of administration: oral. Current US regulatory status: approved.

Key facts

INN iloperidone
Brand FANAPTUM
Mechanism Dopamine D2 receptor antagonist
Target D(2) dopamine receptor
Therapeutic class Nervous system (N05)
Route ORAL
Formulation TABLET
ATC code N05AX14

Mechanism of action

Dopamine D2 receptor antagonist

Primary target: D(2) dopamine receptor

Approval history

Authority Status Date
FDA approved
EMA unknown

Pipeline programs

  1. Iloperidone Phase 3 · Vanda Pharmaceuticals Netherlands · Bipolar I Disorder
  2. Iloperidone Phase 2 · Vanda Pharmaceuticals Netherlands · Parkinson Disease Psychosis
  3. Iloperidone crystalline formulation Phase 2 · Vanda Pharmaceuticals Netherlands · Schizophrenia
  4. iloperidone Phase 2 · Vanda Pharmaceuticals Netherlands · Hypertension
  5. VHX-896 and iloperidone Phase 1 · Vanda Pharmaceuticals Netherlands · Schizophrenia
  6. VHX-896 and iloperidone Phase 1 · Vanda Pharmaceuticals Netherlands · Healthy
  7. iloperidone (oral tablet) Phase 1 · Vanda Pharmaceuticals Netherlands · Safety and Tolerability of Iloperidone
  8. Iloperidone Approved · Vanda Pharmaceuticals Netherlands · Schizophrenia

Related & competitor drugs

  1. aripiprazole Nervous system (N05)
  2. brexpiprazole Nervous system (N05)
  3. brivaracetam Nervous system (N03)
  4. bupivacaine Nervous system (N01)
  5. buprenorphine Nervous system (N07)
  6. cabergoline Dopamine D2 receptor agonist
  1. US 12427132

    Method of improving sleep

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    granted
  2. US 12419869

    Methods of treating multiple sclerosis

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    granted
  3. US 12403134

    Method for improving or enhancing cognition

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    granted
  4. US 12357616

    Methods of treating multiple sclerosis

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    granted
  5. US 11845990

    Prediction of sleep parameter and response to sleep-inducing compound based on PER3 VNTR genotype

    Expires Mon Dec 14 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 11458116

    Method of improving sleep

    Expires Mon Sep 29 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 11433057

    Method for improving or enhancing cognition

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    granted
  8. US 11060144

    Prediction of sleep parameter and response to sleep-inducing compound based on PER3 VNTR genotype

    Expires Mon Jul 08 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 10987346

    Iloperidone for the treatment of schizophrenia

    Expires Mon Apr 22 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 10874659

    Iloperidone metabolite for use in the treatment of psychiatric disorders

    Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 10570452

    Method of predicting a predisposition to QT prolongation

    Expires Mon Feb 20 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 10563261

    Method of predicting a predisposition to QT prolongation

    Expires Mon Feb 13 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 10563260

    Method of predicting a predisposition to QT prolongation

    Expires Mon Feb 13 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 10441580

    Iloperidone for the treatment of schizophrenia

    Expires Mon Oct 10 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 10272076

    Methods for the administration of iloperidone

    Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 10272075

    Method and composition for treating an alpha adrenoceptor-mediated condition

    Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 9987264

    Method and composition for treating a serotonin receptor-mediated condition

    Expires Mon May 31 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 9708291

    Intermediate and process useful in the preparation of {2-[1-(3,5-bis-trifluoromethyl-benzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl)-(2-chlorophenyl)-methanone

    Expires Mon Jul 13 2037 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 9446038

    Method and composition for treating a serotonin receptor-mediated condition

    Expires Mon Sep 15 2036 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 9157121

    Method of treatment based on polymorphisms of the KCNQ1 gene

    Expires Mon Oct 08 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is iloperidone?

iloperidone (FANAPTUM) is a dopamine d2 receptor antagonist. Associated with Vanda Pharmaceuticals Netherlands B.V.. Route of administration: oral. Current US regulatory status: approved.

What is the brand name for iloperidone?

FANAPTUM is a marketed brand name for iloperidone. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of iloperidone?

iloperidone has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.