Wednesday, July 8, 2026

Drug profile · INN

asparaginase erwinia chrysanthemi (recombinant)-rywn

asparaginase erwinia chrysanthemi (recombinant)-rywn (RYLAZE) is a asparagine hydrolytic enzyme. Associated with Jazz Pharmaceuticals Ireland Limited. Route of administration: intramuscular. Current US regulatory status: approved.

FDA: approved
US status approved
Patents linked 8
Pipeline programs 4
News articles 0
Drug details — asparaginase erwinia chrysanthemi (recombinant)-rywn
US status
approved
Class
Route
INTRAMUSCULAR
Patents
8
Programs
4
Data quality
0.89

Quick answer

asparaginase erwinia chrysanthemi (recombinant)-rywn (RYLAZE) is a asparagine hydrolytic enzyme. Associated with Jazz Pharmaceuticals Ireland Limited. Route of administration: intramuscular. Current US regulatory status: approved.

Key facts

INN asparaginase erwinia chrysanthemi (recombinant)-rywn
Brand RYLAZE
Mechanism Asparagine hydrolytic enzyme
Target Asparagine
Route INTRAMUSCULAR
Formulation INJECTABLE

Mechanism of action

Asparagine hydrolytic enzyme

Primary target: Asparagine

Approval history

Authority Status Date
FDA approved

Pipeline programs

  1. Asparaginase Erwinia chrysanthemi Phase 2 · Jazz Pharmaceuticals Ireland · B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Nega
  2. Erwinaze® (Asparaginase Erwinia Chrysanthemi)/Erwinase® (Crisantaspase) Phase 2 · Jazz Pharmaceuticals Ireland · Acute Lymphoblastic Leukemia (ALL)/Lymphoblastic Lymphoma (L
  3. asparaginase Erwinia chrysanthemi Phase 2 · Jazz Pharmaceuticals Ireland · Acute Lymphoblastic Leukemia
  4. Erwinia Chrysanthemi asparaginase Phase 1 · Jazz Pharmaceuticals Ireland · Acute Lymphoblastic Leukemia (ALL)

Related & competitor drugs

  1. crisantaspase Antineoplastic and immunomodulating agents (L01)
  2. calaspargase pegol-mknl Asparagine hydrolytic enzyme
  3. asparaginase Antineoplastic and immunomodulating agents (L01)
  4. pegaspargase Antineoplastic and immunomodulating agents (L01)
  1. US 11413264

    Carbamoyl phenylalaninol analogs and uses thereof

    Expires Mon Aug 11 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 11149000

    Carbamoyl phenylalaninol compounds and uses thereof

    Expires Mon Oct 14 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 10710958

    Carbamoyl phenylalaninol compounds and uses thereof

    Expires Mon Jul 09 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 9707270

    Method for administering ω-conopeptide

    Expires Mon Jul 13 2037 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 9555017

    Methods of making a mixture of salts of gamma-hydroxybutyrate

    Expires Mon Jan 26 2037 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 8765680

    Method for administering omega-conopeptide

    Expires Mon Jun 26 2034 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 8653033

    Method for administering omega-conopeptide

    Expires Mon Feb 13 2034 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 8609651

    Pharmaceutical compositions of benzodiazepines and method of use thereof

    Expires Mon Dec 12 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is asparaginase erwinia chrysanthemi (recombinant)-rywn?

asparaginase erwinia chrysanthemi (recombinant)-rywn (RYLAZE) is a asparagine hydrolytic enzyme. Associated with Jazz Pharmaceuticals Ireland Limited. Route of administration: intramuscular. Current US regulatory status: approved.

What is the brand name for asparaginase erwinia chrysanthemi (recombinant)-rywn?

RYLAZE is a marketed brand name for asparaginase erwinia chrysanthemi (recombinant)-rywn. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of asparaginase erwinia chrysanthemi (recombinant)-rywn?

asparaginase erwinia chrysanthemi (recombinant)-rywn has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.