Wednesday, July 8, 2026

Drug profile · INN

aprocitentan

aprocitentan (JERAYGO) is a endothelin receptor, et-a/et-b antagonist. Route of administration: oral. Current US regulatory status: approved.

FDA: approved EMA: approved Cardiovascular system (C02) C02KN01
US status approved
Patents linked 0
Pipeline programs 2
News articles 1
Drug details — aprocitentan
US status
approved
Class
Cardiovascular system (C02)
Route
ORAL
Patents
0
Programs
2
Data quality
0.84

Quick answer

aprocitentan (JERAYGO) is a endothelin receptor, et-a/et-b antagonist. Route of administration: oral. Current US regulatory status: approved.

Key facts

INN aprocitentan
Brand JERAYGO
Mechanism Endothelin receptor, ET-A/ET-B antagonist
Target Endothelin receptor, ET-A/ET-B
Therapeutic class Cardiovascular system (C02)
Route ORAL
Formulation TABLET
ATC code C02KN01

Mechanism of action

Endothelin receptor, ET-A/ET-B antagonist

Primary target: Endothelin receptor, ET-A/ET-B

Approval history

Authority Status Date
FDA approved
EMA approved

Recent coverage

Pipeline programs

  1. HWK-016, MUCIN-16-targeted ADC Phase 1 · CATALYST PHARMACEUTICALS · PROC
  2. ID-080-111 Phase 1 · Anaxis Pharma · Not applicable - healthy volunteer trial

Related & competitor drugs

  1. alirocumab Cardiovascular system (C10)
  2. aliskiren Cardiovascular system (C09)
  3. azilsartan medoxomil Cardiovascular system (C09)
  4. bempedoic acid Cardiovascular system (C10)
  5. bosentan Cardiovascular system (C02)
  6. dofetilide Cardiovascular system (C01)

Frequently asked questions

What is aprocitentan?

aprocitentan (JERAYGO) is a endothelin receptor, et-a/et-b antagonist. Route of administration: oral. Current US regulatory status: approved.

What is the brand name for aprocitentan?

JERAYGO is a marketed brand name for aprocitentan. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of aprocitentan?

aprocitentan has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.