Wednesday, June 10, 2026

pharma Β· Hypertriglyceridemia Β· Type 2 Diabetes Mellitus Β· IONS

IONIS PHARMACEUTICALS

IONIS PHARMACEUTICALS clinical programs β€” 128 development programs from ClinicalTrials.gov with phase, modality, indication, and trial identifiers.

2855 Gazelle Ct, Carlsbad, CA 92010, US HQ
1989 Founded
1,493 Employees
Public company Type
IONS Β· NYSE Ticker
Company details
Status
Public
HQ
2855 Gazelle Ct, Carlsbad, CA 92010, US
Founded
1989
Employees
1,493
Programs
128
Drugs
48
Patents
222
Intelligence Β· Clinical Programs

IONIS PHARMACEUTICALS projects

128 ClinicalTrials.gov programs sponsored by IONIS PHARMACEUTICALS.

IONIS PHARMACEUTICALS has 128 clinical development programs indexed from ClinicalTrials.gov, including phase, modality, indication text, and linked NCT identifiers.

Clinical programs

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  1. ION775

    IONIS PHARMACEUTICALS INC

    Hypertriglyceridemia

    phase 2 small molecule active

    1 trial
  2. ION904

    IONIS PHARMACEUTICALS INC

    Hypertension

    phase 2 small molecule completed

    1 trial
  3. IONIS DGAT2Rx

    IONIS PHARMACEUTICALS INC

    Hepatic Steatosis

    phase 2 small molecule completed

    1 trial
  4. IONIS GHR-LRx

    IONIS PHARMACEUTICALS INC

    Acromegaly

    phase 2 small molecule completed

    2 trials
  5. IONIS-AGT-LRx

    IONIS PHARMACEUTICALS INC

    Chronic Heart Failure With Reduced Ejection Fraction

    phase 2 small molecule completed

    1 trial
  6. IONIS-DMPKRx

    IONIS PHARMACEUTICALS INC

    Myotonic Dystrophy Type 1

    phase 2 small molecule completed

    1 trial
  7. IONIS-FB-LRx

    IONIS PHARMACEUTICALS INC

    Macular Degeneration

    phase 2 small molecule completed

    1 trial
  8. IONIS-FB-LRx

    IONIS PHARMACEUTICALS INC

    Primary IgA Nephropathy

    phase 2 small molecule completed

    1 trial
  9. IONIS-FB-Lrx

    IONIS PHARMACEUTICALS INC

    Geographic Atrophy

    phase 2 small molecule terminated

    1 trial
  10. IONIS-HBVRx

    IONIS PHARMACEUTICALS INC

    Hepatitis B

    phase 2 small molecule completed

    1 trial
  11. IONIS-PKKRx (ISIS 546254)

    IONIS PHARMACEUTICALS INC

    Chronic Migraine

    phase 2 small molecule completed

    1 trial
  12. IONIS-STAT3Rx

    IONIS PHARMACEUTICALS INC

    Advanced Cancers

    phase 2 small molecule completed

    1 trial
  13. ISIS 104838

    IONIS PHARMACEUTICALS INC

    Rheumatoid Arthritis

    phase 2 small molecule completed

    1 trial
  14. ISIS 113715

    IONIS PHARMACEUTICALS INC

    Type 2 Diabetes Mellitus

    phase 2 small molecule completed

    5 trials
  15. ISIS 14803

    IONIS PHARMACEUTICALS INC

    Hepatitis C, Chronic

    phase 2 small molecule completed

    1 trial
  16. ISIS 14803-CS3

    IONIS PHARMACEUTICALS INC

    Hepatitis C, Chronic

    phase 2 small molecule completed

    1 trial
  17. ISIS 2503

    IONIS PHARMACEUTICALS INC

    Pancreatic Cancer

    phase 2 small molecule completed

    1 trial
  18. ISIS 301012

    IONIS PHARMACEUTICALS INC

    Hypercholesterolemia, Familial

    phase 2 small molecule completed

    1 trial
  19. ISIS 301012 or Placebo

    IONIS PHARMACEUTICALS INC

    Hypercholesterolemia

    phase 2 small molecule completed

    2 trials
  20. ISIS 301012 or Placebo

    IONIS PHARMACEUTICALS INC

    Hypercholesterolemia, Familial

    phase 2 small molecule completed

    1 trial
  21. ISIS 416858

    IONIS PHARMACEUTICALS INC

    End-stage Renal Disease (ESRD)

    phase 2 small molecule completed

    2 trials
  22. ISIS 443139 10 mg

    IONIS PHARMACEUTICALS INC

    Huntington's Disease

    phase 2 small molecule completed

    1 trial
  23. ISIS 678354

    IONIS PHARMACEUTICALS INC

    Hypertriglyceridemia

    phase 2 small molecule completed

    1 trial
  24. ISIS 681257

    IONIS PHARMACEUTICALS INC

    Elevated Lipoprotein(a)

    phase 2 small molecule completed

    1 trial
  25. ISIS 702843

    IONIS PHARMACEUTICALS INC

    Polycythemia Vera

    phase 2 small molecule active

    1 trial
  26. ISIS 721744

    IONIS PHARMACEUTICALS INC

    Hereditary Angioedema

    phase 2 small molecule active

    1 trial
  27. ISIS 721744

    IONIS PHARMACEUTICALS INC

    Covid19

    phase 2 small molecule completed

    1 trial
  28. ISIS CRP Rx

    IONIS PHARMACEUTICALS INC

    Paroxysmal Atrial Fibrillation

    phase 2 small molecule completed

    1 trial
  29. ISIS CRP Rx or Placebo

    IONIS PHARMACEUTICALS INC

    Rheumatoid Arthritis

    phase 2 small molecule completed

    1 trial
  30. ISIS EIF4E Rx

    IONIS PHARMACEUTICALS INC

    Non-small Cell Lung Cancer

    phase 2 small molecule completed

    1 trial
  31. ISIS EIF4E Rx

    IONIS PHARMACEUTICALS INC

    Castrate-Resistant Prostate Cancer

    phase 2 small molecule completed

    1 trial
  32. ISIS apoC-III Rx

    IONIS PHARMACEUTICALS INC

    Hypertriglyceridemia

    phase 2 small molecule completed

    1 trial
  33. ISIS-APO(a)Rx

    IONIS PHARMACEUTICALS INC

    Elevated Lipoprotein(a)

    phase 2 small molecule completed

    1 trial
  34. ISIS-APOCIIIRX

    IONIS PHARMACEUTICALS INC

    Type 2 Diabetes

    phase 2 small molecule terminated

    1 trial
  35. ISIS-FGFR4RX

    IONIS PHARMACEUTICALS INC

    Obesity

    phase 2 small molecule completed

    1 trial
  36. ISIS-FXIRx Dose #2

    IONIS PHARMACEUTICALS INC

    Venous Thromboembolism

    phase 2 small molecule completed

    1 trial
  37. ISIS-GCCRRx

    IONIS PHARMACEUTICALS INC

    Type 2 Diabetes Mellitus

    phase 2 small molecule completed

    1 trial
  38. ISIS-GCGRRx

    IONIS PHARMACEUTICALS INC

    Type 2 Diabetes

    phase 2 small molecule completed

    1 trial
  39. ISIS-GCGRRx - Dose Level 1

    IONIS PHARMACEUTICALS INC

    Type 2 Diabetes Mellitus

    phase 2 small molecule completed

    1 trial
  40. ISIS-GCGRRx- Dose Level 1

    IONIS PHARMACEUTICALS INC

    Type 2 Diabetes

    phase 2 small molecule completed

    1 trial
  41. ISIS-PTP1BRx

    IONIS PHARMACEUTICALS INC

    Type 2 Diabetes Mellitus

    phase 2 small molecule completed

    1 trial
  42. Isis 420915/GSK 299872

    IONIS PHARMACEUTICALS INC

    Amyloidosis

    phase 2 small molecule terminated

    1 trial
  43. Placebo

    IONIS PHARMACEUTICALS INC

    NAFLD

    phase 2 small molecule completed

    1 trial
  44. Placebo

    IONIS PHARMACEUTICALS INC

    Hypertension

    phase 2 small molecule completed

    2 trials
  45. Placebo

    IONIS PHARMACEUTICALS INC

    Mild Hypertension

    phase 2 small molecule completed

    1 trial
  46. mipomersen

    IONIS PHARMACEUTICALS INC

    Metabolic Diseases

    phase 2 small molecule completed

    1 trial
  47. sapablursen

    IONIS PHARMACEUTICALS INC

    Phlebotomy Dependent Polycythemia Vera

    phase 2 small molecule active

    1 trial
  48. sapablursen

    IONIS PHARMACEUTICALS INC

    Beta Thalassemia Intermedia

    phase 2 small molecule terminated

    1 trial

Frequently asked questions

How many clinical projects does IONIS PHARMACEUTICALS have?

128 published programs are linked to this sponsor in our ClinicalTrials.gov index.

Is this the complete company pipeline?

This directory lists published programs for the sponsor in our database. Partnered or out-licensed assets may appear under multiple companies.