Metabolic & obesity · Phase II

Top sponsors

• Takeda 13 programs
• IONIS PHARMACEUTICALS 10 programs
• Oramed Pharmaceuticals 10 programs
• Regeneron UK 10 programs
• United Therapeutics Europe 7 programs
• Anaxis Pharma 6 programs
• NovoThirteen 6 programs
• Vertex Pharmaceuticals (Australia) 6 programs
• vTv Therapeutics 6 programs
• Alnylam Netherlands 5 programs
• LEXICON PHARMACEUTICALS 5 programs
• Rhythm Pharmaceuticals Netherlands 5 programs

1. Phosphate buffered saline for SC administration

   Alnylam Netherlands B.V.

   Type 2 Diabetes Mellitus

   phase 2 · small molecule · active

   1 trial →

2. Pioglitazone and azilsartan

   Takeda

   Diabetes Mellitus

   phase 2 · small molecule · completed

   1 trial →

3. Placebo

   Hoffmann-La Roche

   Diabetes Mellitus Type 2

   phase 2 · small molecule · completed

   1 trial →

4. Placebo

   IONIS PHARMACEUTICALS INC

   NAFLD

   phase 2 · small molecule · completed

   1 trial →

5. Placebo (blinded)

   LEXICON PHARMACEUTICALS, INC.

   Diabetic Peripheral Neuropathic Pain

   phase 2 · small molecule · completed

   1 trial →

6. Placebo for AMG 133, AMG 133

   Amgen

   Type 2 Diabetes Mellitus

   phase 2 · small molecule · active

   1 trial →

7. Placebo to match LY3556050

   Eli Lilly Co.

   Diabetic Peripheral Neuropathy

   phase 2 · small molecule · active

   1 trial →

8. Pramlintide+Metreleptin

   Takeda

   Obesity

   phase 2 · small molecule · terminated

   1 trial →

9. Pro insulin peptide

   Cardiff Oncology

   Type 1 Diabetes

   phase 2 · small molecule · completed

   1 trial →

10. REGN910-3

    Regeneron UK Limited

    Diabetic Macular Edema

    phase 2 · small molecule · completed

    1 trial →

11. Rencofilstat

    Hepion Pharmaceuticals

    Nonalcoholic Steatohepatitis (NASH)

    phase 2 · small molecule · active

    1 trial →

12. Resmetirom

    Madrigal Pharmaceuticals EU Limited

    MASH - Metabolic Dysfunction-Associated Steatohepatitis

    phase 2 · small molecule · active

    1 trial →

13. SAB-142, SODIUM CHLORIDE

    SAB Biotherapeutics

    Type 1 Diabetes

    phase 2 · small molecule · active

    1 trial →

14. SB-509

    SANGAMO THERAPEUTICS, INC

    Diabetes Mellitus, Type 1

    phase 2 · small molecule · completed

    4 trials →

15. SHR20004

    Jian Li

    Obesity

    phase 2 · small molecule · active

    1 trial →

16. SP-GL0034-02

    Lacuna Pharma Pty Ltd

    Type 2 diabetes mellitus

    phase 2 · small molecule · active

    1 trial →

17. SYR-619

    Takeda

    Diabetes Mellitus

    phase 2 · small molecule · terminated

    1 trial →

18. Selinexor

    Karyopharm Therapeutics Inc

    Diabetic Foot Ulcers

    phase 2 · small molecule · terminated

    1 trial →

19. Semaglutide (Rybelsus®)

    The First People's Hospital of Lianyungang

    Obesity-related Male Infertility

    phase 2 · small molecule · active

    1 trial →

20. Setmelanotide

    Rhythm Pharmaceuticals Netherlands B.V.

    Overweight and Obesity

    phase 2 · small molecule · completed

    1 trial →

21. Setmelanotide

    Rhythm Pharmaceuticals Netherlands B.V.

    Genetic Obesity

    phase 2 · small molecule · completed

    2 trials →

22. Sotagliflozin

    LEXICON PHARMACEUTICALS, INC.

    Type 1 Diabetes

    phase 2 · small molecule · active

    2 trials →

23. Suspension of autologous mononuclear cells separated from bone marrow aspirate

    The George Institute

    chronic limb-threatening ischemia, diabetic foot ulcers

    phase 2 · small molecule · active

    1 trial →

24. Suzetrigine

    Vertex Pharmaceuticals (Australia) Pty.

    Diabetic Peripheral Neuropathy

    phase 2 · small molecule · completed

    1 trial →

25. TAK-128

    Takeda

    Diabetic Neuropathies

    phase 2 · small molecule · terminated

    2 trials →

26. TAK-272

    Takeda

    Type 2 Diabetes Mellitus and Microalbuminuria

    phase 2 · small molecule · completed

    1 trial →

27. TAK-379

    Takeda

    Diabetes Mellitus

    phase 2 · small molecule · terminated

    1 trial →

28. TAK-583

    Takeda

    Diabetic Neuropathies

    phase 2 · small molecule · completed

    1 trial →

29. TAK-906 Maleate

    Takeda

    Diabetic Gastroparesis

    phase 2 · small molecule · completed

    1 trial →

30. TAK-906 Maleate

    Takeda

    Diabetes Mellitus and Gastroparesis, Idiopathic Gastroparesis

    phase 2 · small molecule · completed

    1 trial →

31. TAK-954

    Takeda

    Diabetic Gastroparesis

    phase 2 · small molecule · completed

    1 trial →

32. TG-873870 (Nemonoxacin)

    Biotech Pharmaceutical Co.,

    Diabetic Foot Infections

    phase 2 · small molecule · completed

    1 trial →

33. TTP054

    vTv Therapeutics

    Type 2 Diabetes Mellitus

    phase 2 · small molecule · completed

    1 trial →

34. TTP273

    vTv Therapeutics

    Type 2 Diabetes Mellitus

    phase 2 · small molecule · completed

    1 trial →

35. TTP399

    vTv Therapeutics

    Diabetes Mellitus, Type 1

    phase 2 · small molecule · completed

    1 trial →

36. TTP399 400 mg

    vTv Therapeutics

    Diabetes Mellitus, Type 2

    phase 2 · small molecule · completed

    1 trial →

37. TTP435

    vTv Therapeutics

    Obesity

    phase 2 · small molecule · completed

    1 trial →

38. TVB-2640

    Sagimet Biosciences

    Metabolic Dysfunction-assocated Steatohepatitis/ Nonalcoholic Fatty Liver Disease

    phase 2 · small molecule · completed

    1 trial →

39. TVB-2640 25 mg (US)

    Sagimet Biosciences

    MASLD/MASH (Metabolic Dysfunction-Associated Steatotic Liver Disease / Metabolic Dysfunction-Associated Steatohepatitis)

    phase 2 · small molecule · completed

    1 trial →

40. Tangweian Recipe

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Diabetic Gastroenteropathy

    phase 2 · small molecule · active

    1 trial →

41. Tirzepatide

    Regeneron UK Limited

    Obesity

    phase 2 · small molecule · completed

    1 trial →

42. Tradipitant

    Vanda Pharmaceuticals Netherlands B.V.

    Obesity

    phase 2 · small molecule · completed

    1 trial →

43. Trevogrumab-Part A

    Regeneron UK Limited

    Obesity

    phase 2 · small molecule · active

    1 trial →

44. UBT251

    United Therapeutics Europe Ltd

    Metabolic Dysfunction-associated Steatohepatitis (MASH)

    phase 2 · small molecule · active

    1 trial →

45. UBT251

    United Therapeutics Europe Ltd

    Obesity &Amp; Overweight

    phase 2 · small molecule · active

    1 trial →

46. UBT251 Injection 2.0 mg and UBT251 Injection Placebo

    United Therapeutics Europe Ltd

    Obesity &Amp; Overweight

    phase 2 · small molecule · completed

    1 trial →

47. UBT251 Injection 2.0 mg and UBT251 Injection Placebo

    United Therapeutics Europe Ltd

    Type 2 Diabetes Mellitus (T2DM)

    phase 2 · small molecule · completed

    1 trial →

48. VC-02 Combination Product

    Vertex Pharmaceuticals (Australia) Pty.

    Type 1 Diabetes Mellitus With Hypoglycemia

    phase 2 · other · completed

    1 trial →

Frequently asked questions