Autoimmune & immunology · Phase II

Top sponsors

• Takeda 26 programs
• Teva Pharma 13 programs
• Lakefront Biotherapeutics NV 12 programs
• Anaxis Pharma 11 programs
• Chinese Academy of 11 programs
• Novartis India 11 programs
• Sanofi-Aventis U.S 10 programs
• Pacira Ireland 9 programs
• United Therapeutics Europe 8 programs
• RIGEL PHARMACEUTICALS 6 programs
• Regeneron UK 6 programs
• Vertex Pharmaceuticals (Australia) 6 programs

1. Mosunetuzumab

   Hoffmann-La Roche

   Systemic Lupus Erythematosus (SLE) With or Without Active Lupus Nephritis (LN)

   phase 2 · small molecule · active

   1 trial →

2. NDI-034858

   Takeda

   Psoriatic Arthritis

   phase 2 · small molecule · completed

   1 trial →

3. NDI-034858 study drug

   Takeda

   Moderate to Severe Plaque Psoriasis

   phase 2 · small molecule · completed

   1 trial →

4. NKTR-181

   Nektar Therapeutics UK Limited

   Osteoarthritis of the Knee

   phase 2 · small molecule · completed

   1 trial →

5. NMD670-02-0002

   Lacuna Pharma Pty Ltd

   Myasthenia Gravis

   phase 2 · small molecule · active

   1 trial →

6. Namilumab

   Takeda

   Plaque Psoriasis

   phase 2 · small molecule · completed

   1 trial →

7. Namilumab

   Takeda

   Rheumatoid Arthritis

   phase 2 · small molecule · completed

   2 trials →

8. Natrunix

   XBiotech Germany GmbH

   Rheumatoid Arthritis

   phase 2 · small molecule · completed

   1 trial →

9. Natrunix 400 mg

   XBiotech Germany GmbH

   Rheumatoid Arthritis

   phase 2 · mab · active

   1 trial →

10. Natrunix with MTX placebo (+folate)

    XBiotech Germany GmbH

    Rheumatoid Arthritis

    phase 2 · small molecule · active

    1 trial →

11. Not the same excipients as Test, Balinatunfib

    Sanofi-aventis Healthcare Pty Ltd

    Colitis Ulcerative

    phase 2 · small molecule · active

    1 trial →

12. OD-07656

    Odyssey Therapeutics

    Ulcerative Colitis (UC)

    phase 2 · small molecule · active

    1 trial →

13. OD-07656-201

    Odyssey Therapeutics

    Moderately to Severely Active Ulcerative Colitis

    phase 2 · small molecule · active

    1 trial →

14. OPRX-106

    Protalix BioTherapeutics

    Ulcerative Colitis

    phase 2 · small molecule · active

    1 trial →

15. ORKA-001

    Oruka Therapeutics

    Plaque Psoriasis

    phase 2 · small molecule · active

    2 trials →

16. ORKA-001 Induction Dose

    Oruka Therapeutics

    Plaque Psoriasis

    phase 2 · small molecule · active

    1 trial →

17. ORKA-001, Placebo for ORKA-001

    Oruka Therapeutics

    Moderate-to-Severe Plaque Psoriasis

    phase 2 · small molecule · active

    1 trial →

18. ORKA-002

    Oruka Therapeutics

    Plaque Psoriasis

    phase 2 · small molecule · active

    1 trial →

19. Obecabtagene autoleucel

    Autolus GmbH

    Lupus Nephritis

    phase 2 · mab · active

    1 trial →

20. Obexelimab

    Zenas BioPharma

    Systemic Lupus Erythematosus

    phase 2 · small molecule · active

    1 trial →

21. Ocrelizumab

    Hoffmann-La Roche

    Rheumatoid Arthritis

    phase 2 · small molecule · terminated

    1 trial →

22. Oral Chinese Herbal Medicine of Clearing heat and Cooling blood therapy

    The First People's Hospital of Lianyungang

    Psoriasis

    phase 2 · small molecule · active

    1 trial →

23. P38 Inhibitor (4) 150mg

    Hoffmann-La Roche

    Rheumatoid Arthritis

    phase 2 · small molecule · completed

    1 trial →

24. PF-00547659

    Takeda

    Crohn's Disease

    phase 2 · small molecule · completed

    1 trial →

25. PF-00547659 SC injection

    Takeda

    Crohn's Disease

    phase 2 · small molecule · completed

    1 trial →

26. PF-04236921 SC injection

    Pfizer

    Crohn's Disease

    phase 2 · small molecule · completed

    1 trial →

27. PF-06650833

    Pfizer

    Rheumatoid Arthritis

    phase 2 · small molecule · completed

    1 trial →

28. PH-10 (0.001% Rose Bengal)

    PROVECTUS BIOPHARMACEUTICALS, INC.

    Psoriasis

    phase 2 · small molecule · completed

    1 trial →

29. PH-10 (0.002% Rose Bengal)

    PROVECTUS BIOPHARMACEUTICALS, INC.

    Psoriasis

    phase 2 · small molecule · completed

    1 trial →

30. PH-10 (rose bengal disodium 0.001%)

    PROVECTUS BIOPHARMACEUTICALS, INC.

    Plaque Psoriasis

    phase 2 · small molecule · terminated

    1 trial →

31. PN-943

    Protagonist Therapeutics, Inc

    Ulcerative Colitis Chronic Moderate

    phase 2 · small molecule · completed

    1 trial →

32. PTG-100

    Protagonist Therapeutics, Inc

    Ulcerative Colitis

    phase 2 · small molecule · terminated

    1 trial →

33. Placebo

    Takeda

    Ulcerative Colitis

    phase 2 · small molecule · completed

    1 trial →

34. Placebo

    Theravance Biopharma Ireland Umited

    Crohn's Disease

    phase 2 · small molecule · terminated

    1 trial →

35. Placebo

    Vertex Pharmaceuticals (Australia) Pty.

    Rheumatoid Arthritis

    phase 2 · small molecule · completed

    1 trial →

36. Placebo

    Serono Europe Limited

    Systemic Lupus Erythematosus

    phase 2 · small molecule · terminated

    1 trial →

37. Placebo for MK-7240, tulisokibart

    Merck Sharp and Dohme

    Radiographic axial spondyloarthritis (as known as ankylosing spondylitis)

    phase 2 · small molecule · active

    1 trial →

38. Placebo oral capsule

    United Therapeutics Europe Ltd

    Osteoarthritis, Knee

    phase 2 · small molecule · completed

    1 trial →

39. Povetacicept

    Vertex Pharmaceuticals (Australia) Pty.

    Myasthenia Gravis, Generalized

    phase 2 · small molecule · active

    1 trial →

40. R788

    RIGEL PHARMACEUTICALS INC

    Rheumatoid Arthritis

    phase 2 · small molecule · completed

    1 trial →

41. R932333

    RIGEL PHARMACEUTICALS INC

    Lupus Erythematosus, Discoid

    phase 2 · small molecule · completed

    1 trial →

42. REGN475

    Regeneron UK Limited

    Osteoarthritis of the Knee

    phase 2 · small molecule · completed

    1 trial →

43. REGN475

    Regeneron UK Limited

    Osteoarthritis

    phase 2 · mab · terminated

    1 trial →

44. REGN5069

    Regeneron UK Limited

    Osteoarthritis of the Knee

    phase 2 · small molecule · terminated

    1 trial →

45. RF-2021-12375251

    Fondazione Telethon ETS

    Refractory Systemic Autoimmune Diseases

    phase 2 · small molecule · active

    1 trial →

46. RO7790121 placebo, RO7790121

    Hoffmann-La Roche

    Moderate to Severe Rheumatoid Arthritis (RA)

    phase 2 · small molecule · active

    1 trial →

47. Recombinant Anti-IL-17A Humanized Monoclonal Antibody Injection

    Sunshine Guojian Pharmaceutical (Shanghai) Co.,

    Psoriasis

    phase 2 · small molecule · active

    1 trial →

48. Recombinant Anti-IL-1β Humanized Monoclonal Antibody Injection 100 mg

    Sunshine Guojian Pharmaceutical (Shanghai) Co.,

    Gout Arthritis

    phase 2 · small molecule · active

    1 trial →

Frequently asked questions