Autoimmune & immunology · Phase II

Top sponsors

• Takeda 26 programs
• Teva Pharma 13 programs
• Lakefront Biotherapeutics NV 12 programs
• Anaxis Pharma 11 programs
• Chinese Academy of 11 programs
• Novartis India 11 programs
• Sanofi-Aventis U.S 10 programs
• Pacira Ireland 9 programs
• United Therapeutics Europe 8 programs
• RIGEL PHARMACEUTICALS 6 programs
• Regeneron UK 6 programs
• Vertex Pharmaceuticals (Australia) 6 programs

1. Human Umbilical Cord derived MSCs

   CytoMed Therapeutics Ltd

   Lupus Nephritis

   phase 2 · mab · active

   1 trial →

2. Huzhang granule

   Universal Integrated

   Gouty Arthritis

   phase 2 · small molecule · active

   1 trial →

3. I7P-MC-DSAG

   Eli Lilly Co.

   Ulcerative Colitis

   phase 2 · small molecule · active

   1 trial →

4. ICP-022

   Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd

   Systemic Lupus Erythematosus

   phase 2 · small molecule · completed

   1 trial →

5. IDOR-1117-2520 matching placebo

   Lacuna Pharma Pty Ltd

   Moderate to severe chronic plaque psoriasis

   phase 2 · small molecule · active

   1 trial →

6. IRX4204

   IO Biotech

   Psoriasis

   phase 2 · small molecule · on hold

   1 trial →

7. ISIS 104838

   IONIS PHARMACEUTICALS INC

   Rheumatoid Arthritis

   phase 2 · small molecule · completed

   1 trial →

8. ISIS CRP Rx or Placebo

   IONIS PHARMACEUTICALS INC

   Rheumatoid Arthritis

   phase 2 · small molecule · completed

   1 trial →

9. Ibuprofen-PC

   Protalix BioTherapeutics

   Osteoarthritis

   phase 2 · small molecule · completed

   1 trial →

10. Imsidolimab

    Vanda Pharmaceuticals Netherlands B.V.

    Generalized Pustular Psoriasis

    phase 2 · mab · completed

    1 trial →

11. Indigo naturalis ointment

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Psoriasis

    phase 2 · small molecule · completed

    1 trial →

12. J6E-MC-KWAN

    Eli Lilly Co.

    Ulcerative Colitis

    phase 2 · small molecule · active

    1 trial →

13. JBT-101

    Corbus Pharmaceuticals Holdings

    Systemic Lupus Erythematosus

    phase 2 · small molecule · completed

    1 trial →

14. JNJ-77242113

    Janssen Cilag International NV

    Colitis, Ulcerative

    phase 2 · small molecule · completed

    1 trial →

15. JNJ-81241459 for Plaque Psoriasis

    Janssen-Cilag International N.V.

    Plaque Psoriasis

    phase 2 · small molecule · active

    1 trial →

16. JY231 injection

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Systemic Lupus Erythematosus (SLE)

    phase 2 · small molecule · active

    1 trial →

17. Jueyin granules

    Universal Integrated

    Plaque Psoriasis

    phase 2 · small molecule · active

    1 trial →

18. Jueyin granules

    The First People's Hospital of Lianyungang

    Psoriasis Vulgaris

    phase 2 · small molecule · active

    1 trial →

19. KPL-404

    Kiniksa Pharmaceuticals International, plc

    Arthritis, Rheumatoid

    phase 2 · small molecule · completed

    1 trial →

20. KYV-101 anti-CD19 CAR-T cell therapy

    Kyverna Therapeutics

    Lupus Nephritis

    phase 2 · mab · active

    2 trials →

21. KYV101

    Kyverna Therapeutics

    Rheumatoid Arthritis

    phase 2 · small molecule · active

    1 trial →

22. KYV101-003

    Kyverna Therapeutics

    Lupus Nephritis

    phase 2 · other · active

    1 trial →

23. LEO 90105

    LEO Pharma A/S

    Psoriasis Vulgaris

    phase 2 · small molecule · completed

    1 trial →

24. LNA043

    Novartis Pharmaceuticals

    Osteoarthritis

    phase 2 · small molecule · active

    1 trial →

25. LX3305 low dose

    LEXICON PHARMACEUTICALS, INC.

    Rheumatoid Arthritis

    phase 2 · small molecule · completed

    1 trial →

26. LY3471851

    Nektar Therapeutics UK Limited

    Colitis, Ulcerative

    phase 2 · small molecule · terminated

    1 trial →

27. LY3471851

    Nektar Therapeutics UK Limited

    Systemic Lupus Erythematosus

    phase 2 · small molecule · completed

    2 trials →

28. LY3871801

    RIGEL PHARMACEUTICALS INC

    Rheumatoid Arthritis

    phase 2 · small molecule · completed

    1 trial →

29. LY4268989

    Eli Lilly and Company

    Ulcerative Colitis (UC)

    phase 2 · small molecule · active

    1 trial →

30. Lanraplenib

    Lakefront Biotherapeutics NV

    Cutaneous Lupus Erythematosus

    phase 2 · small molecule · completed

    1 trial →

31. Laquinimod

    Teva Pharma GmbH

    Crohn's Disease

    phase 2 · small molecule · completed

    1 trial →

32. Laquinimod

    Teva Pharma GmbH

    Lupus Nephritis

    phase 2 · small molecule · completed

    1 trial →

33. Laquinimod

    Teva Pharma GmbH

    Lupus Arthritis

    phase 2 · small molecule · completed

    1 trial →

34. Leflunomide

    Sanofi Pasteur

    Systemic Lupus Eythematosus (SLE)

    phase 2 · small molecule · completed

    1 trial →

35. Leukocyte-Poor Platelet Rich Plasma (LP-PRP)

    United Therapeutics Europe Ltd

    Osteoarthritis, Knee

    phase 2 · mab · active

    1 trial →

36. Losartan

    United Therapeutics Europe Ltd

    Hip Osteoarthritis

    phase 2 · small molecule · terminated

    1 trial →

37. M23-703

    AbbVie Deutschland GmbH & Co. KG

    Ulcerative Colitis

    phase 2 · small molecule · active

    1 trial →

38. M24-885

    AbbVie Deutschland GmbH & Co. KG

    Moderate to Severe Crohn’s Disease

    phase 2 · small molecule · active

    1 trial →

39. M25-056

    AbbVie Deutschland GmbH & Co. KG

    Rheumatoid Arthritis

    phase 2 · small molecule · active

    1 trial →

40. M5049 low dose

    Merck KGaA, Darmstadt, Germany

    Systemic Lupus Erythematosus

    phase 2 · small molecule · active

    1 trial →

41. MK-6194

    Merck KGaA, Darmstadt, Germany

    Systemic Lupus Erythematosus

    phase 2 · mab · terminated

    1 trial →

42. MOL4239

    Moleculin Biotech

    Psoriasis

    phase 2 · small molecule · completed

    1 trial →

43. MS200569_0003

    Merck Sharp and Dohme

    Systemic lupus erythematosus (SLE) and cutaneous lupus erythematosus (CLE)

    phase 2 · small molecule · active

    1 trial →

44. Maraviroc

    Pfizer

    Arthritis, Rheumatoid

    phase 2 · small molecule · terminated

    1 trial →

45. Match placebo to test product, Balinatunfib

    Sanofi-aventis Healthcare Pty Ltd

    Crohn's disease

    phase 2 · small molecule · active

    1 trial →

46. Mesenchymal progenitor cells

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Knee Osteoarthritis

    phase 2 · mab · completed

    1 trial →

47. Micronized DHACM 40 mg

    United Therapeutics Europe Ltd

    Knee Osteoarthritis

    phase 2 · mab · terminated

    1 trial →

48. Mirikizumab - Intravenous (IV)

    Eli Lilly and Company

    Colitis, Ulcerative

    phase 2 · small molecule · active

    1 trial →

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