Wednesday, July 8, 2026

Patent intelligence · US

US 12281305

Compounds and methods for reducing prion expression

granted A61KA61K31/7088
Status granted
Linked drugs 2
Pipeline programs 6
Years to expiry 19
Applicant portfolio 222
Patent details — US 12281305

Quick answer

US 12281305 (Compounds and methods for reducing prion expression) is held by Ionis Pharmaceuticals, Inc.. Status: granted. Granted Apr 22, 2025. Expires Apr 17, 2045 (19 years remaining) — relevant for patent-cliff and LOE planning.

Key facts

Grant date
Expiration
Claims
29
CPC classes
A61K, A61K31/7088

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Frequently asked questions

What is US patent 12281305?

US 12281305 (Compounds and methods for reducing prion expression) is held by Ionis Pharmaceuticals, Inc.. Status: granted. Granted Apr 22, 2025. Expires Apr 17, 2045 (19 years remaining) — relevant for patent-cliff and LOE planning.

Who owns US 12281305?

Ionis Pharmaceuticals, Inc. is listed as the applicant in USPTO PatentsView records indexed by NovaPharmaNews. We track 222 pharmaceutical patents for this assignee.

When does US 12281305 expire?

Our index shows an expiration date of Apr 17, 2045 (19 years from today). Confirm material dates against USPTO, FDA Orange Book, or qualified counsel before contractual decisions.