Wednesday, July 8, 2026

Drug profile · INN

olezarsen sodium

olezarsen sodium (TRYNGOLZA (AUTOINJECTOR)) is an FDA-listed pharmaceutical active ingredient. Associated with IONIS PHARMACEUTICALS INC. Route of administration: subcutaneous. Current US regulatory status: approved.

FDA: approved
US status approved
Patents linked 20
Pipeline programs 5
News articles 0
Drug details — olezarsen sodium
US status
approved
Class
Route
SUBCUTANEOUS
Patents
20
Programs
5
Data quality
0.89

Quick answer

olezarsen sodium (TRYNGOLZA (AUTOINJECTOR)) is an FDA-listed pharmaceutical active ingredient. Associated with IONIS PHARMACEUTICALS INC. Route of administration: subcutaneous. Current US regulatory status: approved.

Key facts

INN olezarsen sodium
Brand TRYNGOLZA (AUTOINJECTOR)
Route SUBCUTANEOUS
Formulation SOLUTION

Approval history

Authority Status Date
FDA approved

Pipeline programs

  1. Olezarsen Phase 3 · IONIS PHARMACEUTICALS · Severe Hypertriglyceridemia
  2. Olezarsen Phase 3 · IONIS PHARMACEUTICALS · Familial Chylomicronemia Syndrome
  3. Olezarsen Phase 3 · IONIS PHARMACEUTICALS · Hypertriglyceridemia
  4. AUTO CAR T cell therapy Phase 2 · Autolus · Patients Followed for up to 15 Years Following Their First D
  5. Olezarsen Phase 1 · IONIS PHARMACEUTICALS · Healthy Participants
  1. US 12410430

    Modulating apolipoprotein (A) expression

    Expires Mon Sep 04 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 12409188

    Modulators of HSD17B13 expression

    Expires Mon Sep 04 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 12364753

    CD8 binding agents

    Expires Mon Jul 17 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 12350285

    Compounds and methods for reducing ATXN3 expression

    Expires Mon Jul 03 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 12351633

    PD-1 and PD-L1 binding agents

    Expires Mon Jul 03 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 12343357

    Compositions and methods for modulating MECP2 expression

    Expires Mon Jun 26 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 12297431

    Modulation of huntingtin expression

    Expires Mon May 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 12291709

    Compositions and methods for modulating apolipoprotein (a) expression

    Expires Mon May 01 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 12281305

    Compounds and methods for reducing prion expression

    Expires Mon Apr 17 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 12241067

    Compounds and methods for reducing LRRK2 expression

    Expires Mon Feb 27 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 12227746

    Compounds and methods for modulating SCN2A

    Expires Mon Feb 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 12188020

    Methods for reducing Ataxin-2 expression

    Expires Mon Jan 02 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 12180479

    Compounds and methods for modulating ATXN1

    Expires Mon Dec 26 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 12115225

    GLP-1 receptor ligand moiety conjugated oligonucleotides and uses thereof

    Expires Mon Oct 10 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 12110491

    Selective reduction of allelic variants

    Expires Mon Oct 03 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 12042510

    Modulators of IRF4 expression

    Expires Mon Jul 18 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 12043831

    Modulation of alpha synuclein expression

    Expires Mon Jul 18 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 12030910

    Compounds and methods for the modulation of proteins

    Expires Mon Jul 04 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 12018261

    Compounds and methods for modulating factor XII

    Expires Mon Jun 20 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 11959080

    Methods and compositions for inhibiting PMP22 expression

    Expires Mon Apr 11 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is olezarsen sodium?

olezarsen sodium (TRYNGOLZA (AUTOINJECTOR)) is an FDA-listed pharmaceutical active ingredient. Associated with IONIS PHARMACEUTICALS INC. Route of administration: subcutaneous. Current US regulatory status: approved.

What is the brand name for olezarsen sodium?

TRYNGOLZA (AUTOINJECTOR) is a marketed brand name for olezarsen sodium. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of olezarsen sodium?

olezarsen sodium has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.