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Expiring patents (≤24 months)

Patent cliff watchlist — pharmaceutical patents approaching loss of exclusivity.

Patents
1,230

Quick answer

1,230 pharmaceutical patents in our index expire within the next 24 months. Use year facets below for annual patent-cliff planning linked to company and drug profiles.

  1. US 7179823

    5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity

    Takeda Pharmaceutical Company Limited · Granted Tue Feb 20 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 15 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 7179826

    Compositions useful as inhibitors of protein kinases

    Vertex Pharmaceuticals Incorporated · Granted Tue Feb 20 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 15 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 7179899

    Composite antibodies of humanized human subgroup IV light chain capable of binding to TAG-72

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Feb 20 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 15 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 7179462

    α (2) macroglobulin receptor as a heat shock protein receptor and uses thereof

    University of Connecticut Health Center · Granted Tue Feb 20 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 15 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 7179588

    Assay for the detection of paclitaxel resistant cells in human tumors

    The Board of Regents of the University of Texas System · Granted Tue Feb 20 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 15 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 7179621

    Pigment epithelium-derived factor: sequence of the PEDF gene

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Feb 20 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 15 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 7179794

    Multivalent macrolide antibiotics

    Theravance, Inc. · Granted Tue Feb 20 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 15 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 7179445

    Cobalamin conjugates useful as imaging and therapeutic agents

    Regents of the University of Minnesota · Granted Tue Feb 20 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 15 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 7179894

    Combinatorial selection of oligonucleotide aptamers

    The Board of Regents of the University of Texas System · Granted Tue Feb 20 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 15 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 7179815

    Gonadotropin-releasing hormone receptor antagonists and methods relating thereto

    Neurocrine Biosciences, Inc. · Granted Tue Feb 20 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 15 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 7179827

    Thiazoles and methods of their use

    Lexicon Genetics, Inc. · Granted Tue Feb 20 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 15 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 7179834

    Salinosporamides and methods for use thereof

    The Regents of the University of California · Granted Tue Feb 20 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 15 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 7179888

    Antigenic, non-toxic mutants of Clostridium septicum alpha toxin and vaccines, antibodies, sera, and methods of treatment therewith

    The Board of Regents of the University of Oklahoma · Granted Tue Feb 20 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 15 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 7183307

    Pyrazole-derived kinase inhibitors and uses thereof

    Vertex Pharmaceuticals Incorporated · Granted Tue Feb 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 7183388

    Anti-MUC-1 single chain antibodies for tumor targeting

    The Regents of the University of California · Granted Tue Feb 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 7182944

    Methods of increasing distribution of nucleic acids

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Feb 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 7183095

    Cell culture system for synthesis of infectious hepatitis C virus

    The Regents of the University of California · Granted Tue Feb 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 7183255

    Method for stabilizing blood pressure in hemodialysis subjects

    Intradialytic Pharmaceuticals · Granted Tue Feb 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 7183065

    Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using microbial UC pANCA antigens

    The Regents of the University of California · Granted Tue Feb 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 7183267

    β-lactamase inhibitors and methods of use thereof

    Fulcrum Pharmaceuticals Inc. · Granted Tue Feb 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 7183268

    2-amino-9-[(2-hydroxymethyl) cyclopropylidenemethyl] purine antiviral agents

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Feb 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 7183272

    Crystal forms of oxcarbazepine and processes for their preparation

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Feb 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 7183292

    Substituted pyrrolidine and related compounds

    Theravance, Inc. · Granted Tue Feb 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 7183276

    Azole compounds

    Takeda Pharmaceutical Company Limited · Granted Tue Feb 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 7183313

    Keto cannabinoids with therapeutic indications

    UNIVERSITY OF CONNECTICUT · Granted Tue Feb 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 7183334

    Low temperature molding compositions with solid thermoplastic elastomer thickeners and fiber reinforcement

    Reinforced Polymers, Inc. · Granted Tue Feb 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 7183323

    Sodium channel modulators

    Theravance, Inc. · Granted Tue Feb 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 7183401

    NOEY2 gene compositions and methods of use

    The Board of Regents of the University of Texas System · Granted Tue Feb 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 7183415

    Quinoline compound

    Takeda Pharmaceutical Company Limited · Granted Tue Feb 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 7183389

    Monoclonal antibodies and cell surface antigens for the detection and treatment of small cell lung cancer (SCLC)

    Molecular Discoveries, Inc. · Granted Tue Feb 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 7186698

    Spatial and temporal control of gene expression using a heat shock protein promoter in combination with local heat

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Mar 06 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 01 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 7186115

    Advanced thermoplastics for orthodontics

    UNIVERSITY OF CONNECTICUT · Granted Tue Mar 06 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 01 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 7186542

    Method of extracting virus from cell culture

    ONCOLYTICS BIOTECH INC. · Granted Tue Mar 06 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 01 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 7186413

    Hydrogels and water soluble polymeric carriers for drug delivery

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Mar 06 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 01 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 7186737

    Inhibitors of p38

    Vertex Pharmaceuticals Incorporated · Granted Tue Mar 06 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 01 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 7189396

    Delivery system using mAb 3E10 and mutants and/or functional fragments thereof

    The Regents of the University of California · Granted Tue Mar 13 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 08 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 7189865

    Thiomolybdate analogues and uses thereof

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Mar 13 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 08 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 7189704

    6-11 bicyclic ketolide derivatives

    Enanta Pharmaceuticals, Inc. · Granted Tue Mar 13 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 08 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 7189385

    Tooth whitening compositions

    DISCUS DENTAL IMPRESSIONS, LLC · Granted Tue Mar 13 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 08 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 7189513

    Human papilloma virus immunoreactive peptides

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Mar 13 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 08 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 7189393

    Recombinant anti-tumor RNAse

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Mar 13 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 08 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 7189744

    Crystals of benzimidazole compounds

    Takeda Pharmaceutical Company Limited · Granted Tue Mar 13 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 08 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 7189706

    C2,5′-disubstituted and N6,C2,5′-trisubstituted adenosine derivatives and pharmaceutical compositions containing them

    CAN-FITE BIOPHARMA LTD. · Granted Tue Mar 13 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 08 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 7189812

    Human gene critical to fertility

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Mar 13 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 08 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 7189749

    Substituted phenoxyacetic acids

    The Institute for Pharmaceutical Discovery, LLC · Granted Tue Mar 13 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 08 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 7189741

    Indolylpiperidine derivatives as antihistaminic and antiallergic agents

    Almirall Prodesfarma S.A. · Granted Tue Mar 13 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 08 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 7189828

    Glycosulfopeptide inhibitors of leukocyte rolling and methods of use thereof

    The Board of Regents of the University of Oklahoma · Granted Tue Mar 13 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 08 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 7189861

    Processes for preparing amorphous atorvastatin hemi-calcium

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Mar 13 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 08 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is a patent cliff?

A patent cliff is when key pharmaceutical patents expire, opening markets to generics or biosimilars. This hub lists USPTO patents with approaching expiration dates.

Are expiration dates estimates?

Expiration dates derive from USPTO PatentsView grant dates and term estimates. Confirm with Orange Book, patent counsel, and USPTO records before investment decisions.

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