Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2043

Annual patent cliff calendar for 2043 — US pharmaceutical patents by expiration date.

Patents
1,718

Quick answer

1,718 indexed pharmaceutical patents have expiration dates in 2043. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 11549109

    Modified double-stranded RNA agents

    Alnylam Pharmaceuticals, Inc. · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 11548852

    Modified amino acids

    Sutro Biopharma, Inc. · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 11548932

    Anti-VEGF protein compositions and methods for producing the same

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 11547639

    Dental composition containing platinum nanoparticles

    KURARAY NORITAKE DENTAL INC. · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 11548888

    KRas G12C inhibitors

    Mirati Therapeutics, Inc. · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 11549125

    Closed-ended, linear, duplex adenoassociated virus DNA, and uses thereof

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 11548943

    Matrix metalloprotease-cleavable and serine protease-cleavable substrates and methods of use thereof

    CytomX Therapeutics, Inc. · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 11549110

    Modified short interfering nucleic acid (siNA) molecules and uses thereof

    Aligos Therapeutics, Inc. · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 11548945

    T-cell receptor (TCR)-binding antibodies and uses thereof

    The Board of Regents of the University of Texas System · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 11548899

    Fused 1,4-oxazepines and related analogs as BET bromodomain inhibitors

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 11548867

    Amido compounds as AhR modulators

    IDEAYA Biosciences, Inc. · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 11547718

    Modulators of FOXP3 expression

    Ionis Pharmaceuticals, Inc. · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 11548953

    Receptor tyrosine kinase-like orphan receptor 1 (ROR1) single chain Fv antibody fragment conjugates and methods of use thereof

    The Regents of the University of California · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 11548889

    Emetine auristatin compounds

    ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 11548887

    8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists

    Theravance Biopharma R&D IP, LLC · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 11549950

    Cryptic metabolites and method for activating silent biosynthetic gene clusters in diverse microorganisms

    THE TRUSTEES OF PRINCETON UNIVERSITY · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 11547683

    Therapeutic compounds, formulations, and uses thereof

    Tvardi Therapeutics, Inc. · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 11548940

    Anti-interleukin antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device

    Rani Therapeutics, LLC · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 11549113

    Human alzheimer's disease and traumatic brain injury associated tau variants as biomarkers and methods of use thereof

    ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 11547761

    Antibody adjuvant conjugates

    Bolt Biotherapeutics, Inc. · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 11549147

    Treatment of atopic dermatitis with tradipitant

    VANDA PHARMACEUTICALS INC. · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 11548944

    Matrix metalloprotease-cleavable and serine protease-cleavable substrates and methods of use thereof

    CytomX Therapeutics, Inc. · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 11547664

    Compositions and methods for treating eosinophilic disorders

    The Regents of the University of California · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 11547551

    Engineered tendon graft for rotator cuff repair

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 11547101

    Non-human animals having a disruption in a C9ORF72 locus

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 11547759

    Bi-functional compounds and methods for targeted ubiquitination of androgen receptor

    Montelino Therapeutics Inc. · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 11548890

    HPK1 antagonists and uses thereof

    Nimbus Saturn, Inc. · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 11547736

    Sauvignon blanc grape seed products for nonalcoholic fatty liver disease

    The United States of America, as represented by the Secretary of Agriculture · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 11547674

    Protein-polymer hybrid biomaterials

    The Regents of the University of California · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 11549127

    Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

    The Regents of the University of California · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 11547687

    Neprilysin inhibitors

    Theravance Biopharma R&D IP, LLC · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 11547670

    Delayed release methylphenidate compositions

    Amneal Complex Products Research LLC · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 11548951

    Compositions and methods for treatment of thyroid eye disease

    Viridian Therapeutics, Inc. · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 11547663

    Unit aerosol doses for anticoagulation

    The Regents of the University of California · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 11548947

    Bispecific anti-PSMA X anti-CD28 antibodies and uses thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 11549112

    RNAi agents for inhibiting expression of xanthine dehydrogenase (XDH), pharmaceutical compositions thereof, and methods of use

    Arrowhead Pharmaceuticals, Inc. · Granted Tue Jan 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 05 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 11554168

    HIV vaccines comprising one or more population episensus antigens

    Vir Biotechnology, Inc. · Granted Tue Jan 17 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 12 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 11554114

    Methods and compositions for self-regulated release of active pharmaceutical ingredients

    Acurx Pharmaceuticals, Inc. · Granted Tue Jan 17 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 12 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 11555060

    QTY FC fusion water soluble receptor proteins

    Avalon GloboCare Corp. · Granted Tue Jan 17 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 12 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 11555021

    Fatty acid derivatives and their use

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jan 17 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 12 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 11555057

    Compositions and methods for inhibiting tumor cells by inhibiting the transcription factor ATF5

    The Regents of the University of California · Granted Tue Jan 17 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 12 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 11555189

    Antisense oligomer compounds

    Sarepta Therapeutics, Inc. · Granted Tue Jan 17 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 12 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 11554101

    Process for encapsulating soluble biologics, therapeutics, and imaging agents

    THE TRUSTEES OF PRINCETON UNIVERSITY · Granted Tue Jan 17 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 12 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 11554140

    Nucleic acid, chimeric antigen receptor expression plasmid, chimeric antigen receptor expressing cell, use thereof, and pharmaceutical composition for treating cancer

    China Medical University Hospital · Granted Tue Jan 17 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 12 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 11555041

    Bridged bicyclic inhibitors of menin-MLL and methods of use

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jan 17 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 12 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 11555064

    Treating headache comprising administering an antibody to calcitonin gene-related peptide

    TEVA PHARMACEUTICALS INTERNATIONAL GMBH · Granted Tue Jan 17 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 12 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 11555068

    Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device

    Rani Therapeutics, LLC · Granted Tue Jan 17 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 12 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 11554103

    Compositions and methods to reduce pharmaceutical-induced toxicity

    Northwestern University · Granted Tue Jan 17 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 12 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2043?

1,718 published patents in our USPTO index have expiration dates falling in calendar year 2043.