Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2043

Annual patent cliff calendar for 2043 — US pharmaceutical patents by expiration date.

Patents
1,718

Quick answer

1,718 indexed pharmaceutical patents have expiration dates in 2043. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 11617766

    Notch receptors with hinge domain

    The Regents of the University of California · Granted Tue Apr 04 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 30 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 11617742

    Methods of treating keratin hyperproliferation disorders using mTOR inhibitors

    PALVELLA THERAPEUTICS, INC. · Granted Tue Apr 04 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 30 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 11618784

    Anti-CD47 combination therapy

    TEVA PHARMACEUTICALS AUSTRALIA PTY LTD · Granted Tue Apr 04 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 30 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 11617771

    Oral composition comprising lactic acid bacteria for regulating immune responses and methods related thereto

    The Regents of the University of California · Granted Tue Apr 04 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 30 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 11617793

    Anhydrous sodium thiosulfate and formulations thereof

    Fennec Pharmaceuticals, Inc. · Granted Tue Apr 04 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 30 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 11617769

    Methods of transdifferentiation and methods of use thereof

    TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. · Granted Tue Apr 04 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 30 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 11618746

    Inhibitors of APOL1 and methods of using same

    Vertex Pharmaceuticals Incorporated · Granted Tue Apr 04 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 30 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. KR 20230047080

    오피카폰의 고체 분산물

    BIAL PORTELA & CA SA [PT] · Granted Thu Apr 06 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Apr 01 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. WO 2023054310

    ENSEMBLE DE PERFUSION GOUTTE-À-GOUTTE INTRAVEINEUX POURVU D'UN FILTRE DE PERFUSION À ÉVENT D'AIR

    BASILEA PHARMACEUTICA INT AG ALLSCHWIL [CH] · Granted Thu Apr 06 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Apr 01 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 11624125

    Stabilization of colloidal crystals engineered with nucleic acid

    Northwestern University · Granted Tue Apr 11 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 06 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 11622977

    Materials and methods for engineering cells and uses thereof in immuno-oncology

    CRISPR THERAPEUTICS AG · Granted Tue Apr 11 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 06 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 11622968

    Heterocyclic modulators of lipid synthesis

    Sagimet Biosciences Inc. · Granted Tue Apr 11 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 06 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 11623923

    Uracil compound as c-MET/AXL inhibitor

    Medshine Discovery Inc. · Granted Tue Apr 11 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 06 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 11622933

    Soluble estradiol capsule for vaginal insertion

    Compass Therapeutics LLC · Granted Tue Apr 11 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 06 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 11622991

    Protocol for treatment of lupus nephritis

    AURINIA PHARMACEUTICALS INC. · Granted Tue Apr 11 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 06 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 11623918

    Compounds for the treatment of acute and chronic kidney disease

    United States Government as represented by the Department of Veterans Affairs · Granted Tue Apr 11 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 06 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 11623011

    Dually derivatized chitosan nanoparticles and methods of making and using the same for gene transfer in vivo

    ENGENE, INC. · Granted Tue Apr 11 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 06 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 11623012

    Bicyclic peptide ligands specific for EphA2

    BicycleRD Limited · Granted Tue Apr 11 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 06 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 11623924

    Modulators of alpha-1 antitrypsin

    Vertex Pharmaceuticals Incorporated · Granted Tue Apr 11 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 06 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 11623930

    Imidazodiazepinediones and methods of use thereof

    Goldfinch Bio, Inc. · Granted Tue Apr 11 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 06 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 11623932

    Protein degraders and uses thereof

    Kymera Therapeutics, Inc. · Granted Tue Apr 11 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 06 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 11623002

    ALK polypeptides and methods of use thereof

    Elicio Therapeutics, Inc. · Granted Tue Apr 11 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 06 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 11623927

    Substituted [1,2,4]triazolo[1,5-a]pyrimidines for stabilizing microtubules

    The Regents of the University of California · Granted Tue Apr 11 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 06 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 11622975

    Compositions and methods for improved honey bee health

    The United States of America, as represented by the Secretary of Agriculture · Granted Tue Apr 11 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 06 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 11622970

    BCL-2 inhibitors and their use as pharmaceuticals

    Prelude Therapeutics, Incorporated · Granted Tue Apr 11 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 06 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 11623929

    Spirocyclic compounds

    C4 THERAPEUTICS, INC. · Granted Tue Apr 11 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 06 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 11622954

    Estrogen receptor ligands, compositions and methods related thereto

    The Regents of the University of California · Granted Tue Apr 11 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 06 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 11623945

    Immunostimulating compositions and uses therefore

    The United States of America, as represented by the Secretary of Agriculture · Granted Tue Apr 11 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 06 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 11623010

    Pharmaceutical carrier in the preparation of an anti-diabetic pharmaceutical composition and methods for treatment

    BEIJING RONGXIANG INSTITUTE OF REGENERATIVE MEDICINE CO., LTD. · Granted Tue Apr 11 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 06 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 11622547

    Genetically modified mouse that expresses human albumin

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Apr 11 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 06 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. IT 202100026282

    Surnatante fermentato e composizioni postbiotiche utili nella prevenzione e nel trattamento di malattie cardiovascolari

    ALFASIGMA SPA [IT] · Granted Thu Apr 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Apr 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 11629159

    Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use

    Compass Pathfinder Limited · Granted Tue Apr 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 11628177

    Compositions and methods for deep dermal drug delivery

    ARCUTIS BIOTHERAPEUTICS, INC. · Granted Tue Apr 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 11629167

    Betulastatin compounds

    ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY · Granted Tue Apr 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 11629349

    RNAi agents for inhibiting expression of xanthine dehydrogenase (XDH), pharmaceutical compositions thereof, and methods of use

    Arrowhead Pharmaceuticals, Inc. · Granted Tue Apr 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 11628146

    Estrogen receptor ligand treatment for neurodegenerative diseases

    The Regents of the University of California · Granted Tue Apr 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 11629122

    Linkers for antibody drug conjugates

    The Board of Regents of the University of Texas System · Granted Tue Apr 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 11628215

    HIV vaccines comprising one or more population episensus antigens

    Vir Biotechnology, Inc. · Granted Tue Apr 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 11629145

    SHP2 phosphatase inhibitors and methods of use thereof

    Relay Therapeutics, Inc. · Granted Tue Apr 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 11629174

    Cryptic metabolites and method for activating silent biosynthetic gene clusters in actinomycete bacteria

    THE TRUSTEES OF PRINCETON UNIVERSITY · Granted Tue Apr 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 11629146

    Substituted [1,2,4]triazolo[4,3-a]pyrazines as modulators of sodium channel activity

    PRAXIS PRECISION MEDICINES, INC. · Granted Tue Apr 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 11628205

    Conjugates of a factor VIII moiety having an oxime-containing linkage

    Nektar Therapeutics · Granted Tue Apr 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 11628229

    Method of synthesizing 18F radiolabeled biomolecular agents

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Apr 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 11629060

    Purification of clinoptilolite

    Revelation Health LLC · Granted Tue Apr 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 11628173

    Pharmaceutical compositions comprising meloxicam

    AXSOME THERAPEUTICS, INC. · Granted Tue Apr 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 11629195

    Anti-IL2 receptor gamma antigen-binding proteins

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Apr 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 11629334

    Methods of isolating T cells and T cell receptors having antigenic specificity for a cancer-specific mutation from peripheral blood

    THE UNITED STATES OF AMERICA, represented by the Secretary, Department of Health and Human Services · Granted Tue Apr 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 11631483

    Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy

    Iovance Biotherapeutics, Inc. · Granted Tue Apr 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2043?

1,718 published patents in our USPTO index have expiration dates falling in calendar year 2043.