Wednesday, June 10, 2026
🇺🇸 FDA

Intelligence · Patents

Patents expiring in 2043

Annual patent cliff calendar for 2043 — US pharmaceutical patents by expiration date.

Patents
1,718

Quick answer

1,718 indexed pharmaceutical patents have expiration dates in 2043. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 11608378

    Antibodies that bind integrin AVB8 and uses thereof

    The Regents of the University of California · Granted Tue Mar 21 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 16 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 11613511

    Methods of making bempedoic acid and compositions of the same

    Esperion Therapeutics, Inc. · Granted Tue Mar 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 11613502

    Core-shell ceramic particle colloidal gel and solid oxide fuel cell electrolyte

    The Regents of the University of Colorado · Granted Tue Mar 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 11612608

    Methods of treating oral mucositis

    Galera Labs, LLC · Granted Tue Mar 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 11612662

    Multi-arm polymeric prodrug conjugates of pemetrexed-based compounds

    Nektar Therapeutics · Granted Tue Mar 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 11613754

    Toxic RNAi active seed sequences for killing cancer cells

    Northwestern University · Granted Tue Mar 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 11613527

    Enzyme inhibitors

    KalVista Pharmaceuticals Limited · Granted Tue Mar 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 11613752

    Compositions and methods for modulating PKK expression

    Ionis Pharmaceuticals, Inc. · Granted Tue Mar 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 11613538

    Method of inhibiting or reducing a viral infection

    PTC THERAPEUTICS, INC. · Granted Tue Mar 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 11612675

    Fish skin biologic bandage

    The Regents of the University of California · Granted Tue Mar 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 11612657

    Biodegradable lipids for the delivery of active agents

    Alnylam Pharmaceuticals, Inc. · Granted Tue Mar 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 11612663

    Proteoglycan mimetics for enhanced wound healing, angiogenesis, and vascular repair

    The Regents of the University of California · Granted Tue Mar 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 11613544

    Substituted imidazo[1,5-a]pyrazines for modulation of IRE1

    The Regents of the University of California · Granted Tue Mar 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 11612580

    Compositions for inhibiting 3′ repair exonuclease 2 and methods of screening for such compositions

    The Board of Regents of the University of Texas System · Granted Tue Mar 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 11613758

    Engineered bacteria for production and release of therapeutics

    The Regents of the University of California · Granted Tue Mar 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 11613750

    Methods of reducing virus molecule levels

    Aligos Therapeutics, Inc. · Granted Tue Mar 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 11613559

    Nucleic acid construct

    AUTOLUS LIMITED · Granted Tue Mar 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 11613744

    Modified urokinase-type plasminogen activator polypeptides and methods of use

    Vertex Pharmaceuticals Incorporated · Granted Tue Mar 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 11613560

    Bicyclic peptide ligands specific for OX40

    BicycleTx Limited · Granted Tue Mar 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 11613764

    T cell receptors that bind to NY-ESO-1 and methods of use thereof

    MiNK Therapeutics, Inc. · Granted Tue Mar 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 11613586

    Methods and materials for assessing response to plasmablast- and plasma cell-depleting therapies

    Takeda Pharmaceutical Company Limited · Granted Tue Mar 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 11613528

    Small molecule inhibitors of shared epitope-calreticulin interactions and methods of use

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Mar 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 11613735

    Methods for reprograming non-hepatocyte cells into hepatocyte cells

    BeiHao Stem Cell and Regenerative Medicine Translational Research Institute · Granted Tue Mar 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 11612575

    Combination therapies with disulfiram

    Spring Discovery, Inc. · Granted Tue Mar 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 11613551

    Aminoglycoside derivatives and uses thereof in treating genetic disorders

    ELOXX PHARMACEUTICALS LTD. · Granted Tue Mar 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 11613739

    Treatment of mucopolysaccharidosis II with recombinant human iduronate-2-sulfatase (IDS) produced by human neural or glial cells

    REGENXBIO INC. · Granted Tue Mar 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 11612652

    Lipids as synthetic vectors to enhance antigen processing and presentation ex-vivo in dendritic cell therapy

    PDS Biotechnology Corporation · Granted Tue Mar 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 11612870

    Microencapsulation of chemicals and bioactives by in situ complex coacervation during spray drying

    The Regents of the University of California · Granted Tue Mar 28 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 23 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. AR 124446

    POLIPÉPTIDOS RECLUTADORES DE CÉLULAS T BASADOS EN LA REACTIVIDAD DE TCR a / b

    ABLYNX NV [BE] · Granted Wed Mar 29 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Tue Mar 24 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. AR 124426

    POLIPÉPTIDOS QUE COMPRENDEN DOMINIOS VARIABLES ÚNICOS DE INMUNOGLOBULINA QUE SE DIRIGEN A IL-6 Y TNF-a

    ABLYNX NV [BE] · Granted Wed Mar 29 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Tue Mar 24 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. AR 124425

    POLIPÉPTIDOS QUE COMPRENDEN DOMINIOS VARIABLES SIMPLES DE INMUNOGLOBULINA DIRIGIDOS A GLYPICAN-3 Y AL RECEPTOR DE CÉLULAS T

    ABLYNX NV [BE] · Granted Wed Mar 29 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Tue Mar 24 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. CA 3230895

    TRAITEMENTS AVEC DES COMPOSES PTH A ACTION PROLONGEE

    ASCENDIS PHARMA BONE DISEASES AS [DK] · Granted Thu Mar 30 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Mar 25 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. AU 2021323364

    Antimicrobial peptidomimetics

    BASILEA PHARMACEUTICA INTERNATIONAL AG ALLSCHWIL [CH] · Granted Thu Mar 30 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Mar 25 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. AU 2021319613

    Antimicrobial peptidomimetics

    BASILEA PHARMACEUTICA INTERNATIONAL AG ALLSCHWIL [CH] · Granted Thu Mar 30 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Mar 25 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. WO 2023046844

    COMPOSITIONS PHARMACEUTIQUES UTILES POUR LA PRÉVENTION OU LE TRAITEMENT D'INFECTIONS VIRALES

    BIOCODEX [FR] · Granted Thu Mar 30 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Mar 25 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 11617753

    Methods of treating and inhibiting Ebola virus infection

    The United States of America, as represented by the Secretary, Health and Human Services · Granted Tue Apr 04 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 30 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 11618731

    Prodrugs of kallikrein inhibitors

    BioCryst Pharmaceuticals, Inc. · Granted Tue Apr 04 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 30 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 11617796

    Conjugate of minoxidil and peptide

    CAREGEN CO., LTD. · Granted Tue Apr 04 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 30 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 11617756

    Pharmaceutical compositions comprising meloxicam

    AXSOME THERAPEUTICS, INC. · Granted Tue Apr 04 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 30 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 11617771

    Oral composition comprising lactic acid bacteria for regulating immune responses and methods related thereto

    The Regents of the University of California · Granted Tue Apr 04 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 30 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 11617761

    Methods for treating NLRP3 inflammasome-associated diseases, and methods of identifying agents useful therefor

    The Regents of the University of California · Granted Tue Apr 04 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 30 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 11617769

    Methods of transdifferentiation and methods of use thereof

    TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. · Granted Tue Apr 04 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 30 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 11617793

    Anhydrous sodium thiosulfate and formulations thereof

    Fennec Pharmaceuticals, Inc. · Granted Tue Apr 04 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 30 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 11617770

    Sporeforming probiotic strains, methods and uses thereof

    CIIMAR—CENTRO INTERDISCIPLINAR DE INVESTIGACAO MARINHA E AMBIENTAL · Granted Tue Apr 04 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 30 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 11617801

    RP2 and RPGR vectors for treating X-linked retinitis pigmentosa

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Apr 04 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 30 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 11618733

    Crystalline salts of a plasma kallikrein inhibitor

    BioCryst Pharmaceuticals, Inc. · Granted Tue Apr 04 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 30 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 11617788

    Viral promoters and compositions and methods of use thereof

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Apr 04 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 30 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 11617766

    Notch receptors with hinge domain

    The Regents of the University of California · Granted Tue Apr 04 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 30 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2043?

1,718 published patents in our USPTO index have expiration dates falling in calendar year 2043.

Drug approvals, clinical trials, M&A, event intelligence, and company updates — weekly.

Customize topics & region
Topics
Region

No spam. Unsubscribe anytime. See our privacy policy.