Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2043

Annual patent cliff calendar for 2043 — US pharmaceutical patents by expiration date.

Patents
1,718

Quick answer

1,718 indexed pharmaceutical patents have expiration dates in 2043. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 11672872

    Anti-transferrin receptor antibody and uses thereof

    Dyne Therapeutics, Inc. · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 11673860

    Crystalline siponimod fumaric acid and polymorphs thereof

    TEVA PHARMACEUTICALS INTERNATIONAL GMBH · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 11673898

    Substituted inhibitors of menin-MLL and methods of use

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 11672813

    Bortezomib compositions

    MAIA PHARMACEUTICALS, INC. · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 11672785

    Tetrahydro-1H-pyrido [3,4-b]indole anti-estrogenic drugs

    Olema Pharmaceuticals, Inc. · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 11672811

    Materials and methods for suppressing and/or treating bone related diseases and symptoms

    The United States of America as Represented by the Department of Veteranas Affairs · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 11673879

    Substituted pyrimidines and methods of use

    Theravance Biopharma R&D IP, LLC · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 11672832

    Development of amnion-like tissue from human pluripotent stem cells

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 11672749

    Peptide exhibiting wrinkle-improving activity and uses thereof

    CAREGEN CO., LTD. · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 11673902

    Isoindolinone and indazole compounds for the degradation of EGFR

    C4 THERAPEUTICS, INC. · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 11673899

    Crystal form of thieno[2,3-c]pyridazine-4(1H)-one compound, preparation method therefor and use thereof

    Medshine Discovery Inc. · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 11672791

    Tyrosine kinase inhibitors

    Rigel Pharmaceuticals, Inc. · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 11672794

    Therapeutic targeting of the BAP1 complex in cancer

    Northwestern University · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 11672793

    Compositions of CXCR4 inhibitors and methods of preparation and use

    X4 Pharmaceuticals, Inc. · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 11672863

    Enhanced solubility drug-containing formulations

    United Therapeutics Corporation · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 11672775

    Treprostinil prodrugs

    United Therapeutics Corporation · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 11673864

    Pyridone amides as modulators of sodium channels

    Vertex Pharmaceuticals Incorporated · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 11672776

    Multi-arm polymeric alkanoate conjugates

    Nektar Therapeutics · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 11673887

    N-acyl amino acid compounds and methods of use

    Pliant Therapeutics, Inc. · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 11672871

    Peptide oligonucleotide conjugates

    Sarepta Therapeutics, Inc. · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 11673867

    Sulfonamide derivative or pharmaceutically acceptable acid-addition salt

    The Board of Regents of the University of Texas System · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 11674177

    Kelch domain containing 7B (KLHDC7B) variants and uses thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jun 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 08 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. KR 20230088753

    파킨슨병 치료를 위한 오피카폰 및 레보도파

    BIAL PORTELA & CA SA [PT] · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 11680093

    Monoclonal antibodies that specifically bind to matrilin 3 and their use

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 11679128

    Methods of producing enriched populations of tumor reactive T cells from peripheral blood

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 11680067

    Small molecules for the treatment of primary cancer and cancer metastasis

    The Board of Regents of the University of Texas System · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 11680249

    Adeno-associated virus capsid variants and methods of use thereof

    The Regents of the University of California · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 11680034

    Fluoroalkyl, fluoroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders

    PTC THERAPEUTICS, INC. · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 11679113

    Anticancer treatment for uveal melanoma

    The Regents of the University of California · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 11679159

    Compositions for transfecting resistant cell types

    Precision Nanosystems ULC · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 11679161

    Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy

    Dyne Therapeutics, Inc. · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 11680036

    Methods for making and using endoxifen

    ATOSSA THERAPEUTICS, INC. · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 11680254

    Engineered meganucleases specific for recognition sequences in the PCSK9 gene

    Precision BioSciences, Inc. · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 11679119

    Bortezomib compositions

    MAIA PHARMACEUTICALS, INC. · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 11679131

    Genetically engineered T cells with regnase-1 and/or TGFBRII disruption have improved functionality and persistence

    CRISPR THERAPEUTICS AG · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 11679109

    SMARCA degraders and uses thereof

    Kymera Therapeutics, Inc. · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 11680070

    Thieno[2,3-c]pyridazin-4(1H)-one derivative and application thereof

    Medshine Discovery Inc. · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 11680090

    Interleukin-2 fusion proteins and uses thereof

    Medicenna Therapeutics Inc. · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 11680079

    Nucleic acid aptamers to treat histone-induced disease states

    The United States Government as Represented by The Department of Veteran Affairs · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 11679078

    Ophthalmic formulations and related methods

    ETERNATEAR, INC. · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 11679079

    Ophthalmic formulations and related methods

    ETERNATEAR, INC. · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 11679103

    Multi-targeting agents for Alzheimer's disease therapy

    The Regents of the University of California · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 11679112

    Cancer treatments using combinations of CDK and ERK inhibitors

    Biomed Valley Discoveries, Inc. · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 11679158

    Biodegradable lipids for the delivery of active agents

    Alnylam Pharmaceuticals, Inc. · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 11679075

    Methods for administration and methods for treating cardiovascular diseases with resiniferatoxin

    BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 11680062

    3,4-methylenedioxyphenylimidazolylethanonexime ether derivative, preparation method and use thereof, and drug for the treatment of Alzheimer's disease

    Northwest A & F University · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 11679150

    Mycoplasma bovis vaccine product

    The United States of America, as represented by the Secretary of Agriculture · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 11679101

    Anhydrous compositions of mTOR inhibitors and methods of use

    PALVELLA THERAPEUTICS, INC. · Granted Tue Jun 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2043?

1,718 published patents in our USPTO index have expiration dates falling in calendar year 2043.