Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2043

Annual patent cliff calendar for 2043 — US pharmaceutical patents by expiration date.

Patents
1,718

Quick answer

1,718 indexed pharmaceutical patents have expiration dates in 2043. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 11648307

    Anti-DC-HIL antibodies for cancer diagnosis, prognosis and therapy

    The Board of Regents of the University of Texas System · Granted Tue May 16 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 11 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 11649454

    Single-stranded RNA-editing oligonucleotides

    ProQR Therapeutics II B.V. · Granted Tue May 16 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 11 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 11648209

    Compositions and methods for organ specific delivery of nucleic acids

    The Board of Regents of the University of Texas System · Granted Tue May 16 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 11 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 11647776

    Extract, consumable product and method for enriching bioactive metabolite in an extract

    Brightseed, Inc. · Granted Tue May 16 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 11 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 11649438

    Methods and compositions for treating cancer

    CRISPR THERAPEUTICS AG · Granted Tue May 16 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 11 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 11649237

    Substituted imidazo[1,5-a]pyrazines for IRE1 inhibition

    The Regents of the University of California · Granted Tue May 16 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 11 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 11648297

    Bioresponsive particles

    The Board of Regents of the University of Texas System · Granted Tue May 16 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 11 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 11648247

    Compositions and methods for the treatment of presbyopia

    Lenz Therapeutics, Inc. · Granted Tue May 16 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 11 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 11649273

    Anti-VEGF protein compositions and methods for producing the same

    REGENERON PHARMACEUTICALS, INC. · Granted Tue May 16 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 11 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 11648211

    Nanoencapsulated combination drug formulations

    Northwestern University · Granted Tue May 16 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 11 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 11648245

    Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators

    Corcept Therapeutics Incorporated · Granted Tue May 16 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 11 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 11649468

    Targeted integration into the PPP1R12C locus

    Sangamo Therapeutics, Inc. · Granted Tue May 16 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 11 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 11649261

    Crystalline forms of a CD73 inhibitor and uses thereof

    Arcus Biosciences, Inc. · Granted Tue May 16 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 11 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 11649459

    Superoxide dismutase 1 (SOD1) iRNA compositions and methods of use thereof for treating or preventing superoxide dismutase 1-(SOD1-) associated neurodegenerative diseases

    Alnylam Pharmaceuticals, Inc. · Granted Tue May 16 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 11 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 11649251

    Substituted inhibitors of menin-MLL and methods of use

    Kura Oncology, Inc. · Granted Tue May 16 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 11 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 11649230

    Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof

    VTV THERAPEUTICS LLC · Granted Tue May 16 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 11 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 11649218

    C-Abl tyrosine kinase inhibitory compound embodiments and methods of making and using the same

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue May 16 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 11 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 11648318

    Anti-transferrin receptor (TFR) antibody and uses thereof

    Dyne Therapeutics, Inc. · Granted Tue May 16 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 11 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 11648304

    Zika vaccines and immunogenic compositions, and methods of using the same

    Takeda Vaccines, Inc. · Granted Tue May 16 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 11 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 11649206

    Method for producing pyrrole compound

    Takeda Pharmaceutical Company Limited · Granted Tue May 16 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 11 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 11648274

    Polypeptide

    AUTOLUS LIMITED · Granted Tue May 16 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 11 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. CA 3240096

    POLYTHERAPIE POUR LE TRAITEMENT DU CANCER DU POUMON

    NOVARTIS AG [CH] · Granted Fri May 19 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Thu May 14 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 11655275

    Methods and compositions for modification of a cystic fibrosis transmembrane conductance regulator (CFTR) gene

    Sangamo Therapeutics, Inc. · Granted Tue May 23 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 18 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 11655455

    Enhanced systems for cell-mediated oncolytic viral therapy

    Calidi Biotherapeutics, Inc. · Granted Tue May 23 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 18 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 11654124

    Stabilized formulations of 4-amino-3-substituted butanoic acid derivatives

    AMNEAL PHARMACEUTICALS LLC · Granted Tue May 23 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 18 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 11655241

    Heterocyclic compound and use thereof

    Takeda Pharmaceutical Company Limited · Granted Tue May 23 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 18 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 11654166

    Therapeutic bacteriophage compositions for treating Staphylococcus infection

    Armata Pharmaceuticals, Inc. · Granted Tue May 23 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 18 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 11654097

    Peptide having activities of skin whitening and uses thereof

    CAREGEN CO., LTD. · Granted Tue May 23 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 18 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 11655282

    Chimeric engulfment receptor molecules

    Cero Therapeutics Holdings, Inc. · Granted Tue May 23 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 18 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 11654199

    Thienoazepine immunoconjugates, and uses thereof

    Bolt Biotherapeutics, Inc. · Granted Tue May 23 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 18 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 11654182

    Method of delivering gonadotropin releasing hormone or an analogue thereof into a lumen of the intestinal tract using a swallowable drug delivery device

    Rani Therapeutics, LLC · Granted Tue May 23 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 18 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 11654147

    ALK2 inhibitors and methods for inhibiting BMP signaling

    The United States of America as Represented by the Secretary, Dept. of Health and Human Services · Granted Tue May 23 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 18 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 11654142

    Methods for the administration of certain VMAT2 inhibitors

    Neurocrine Biosciences, Inc. · Granted Tue May 23 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 18 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 11655469

    MicroRNAs and methods of their use

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue May 23 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 18 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 11655291

    Compositions and methods for increasing muscle mass and muscle strength by specifically antagonizing GDF8 and or activin A

    REGENERON PHARMACEUTICALS, INC. · Granted Tue May 23 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 18 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 11655288

    Antibodies to oxidized phospholipids

    The Regents of the University of California · Granted Tue May 23 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 18 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 11655286

    Anti-PcrV antibodies that bind PcrV, compositions comprising anti-PcrV antibodies, and methods of use thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue May 23 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 18 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 11655248

    Pyridone-pyrimidine derivative acting as KRAS G12C mutein inhibitor

    Medshine Discovery Inc. · Granted Tue May 23 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 18 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 11655454

    Method and apparatus for improved mesenchymal stem cell harvesting

    Elite IP, LLC · Granted Tue May 23 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 18 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 11654293

    Laser assisted wound healing protocol and system

    THE BIOREGENTECH INSTITUTE, INC. · Granted Tue May 23 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 18 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 11654193

    Cancer treatment combinations

    The Regents of the University of California · Granted Tue May 23 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 18 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 11654187

    Horn fly protein as active antigen in anti-horn fly vaccine for protection of bovines against horn fly infestations

    The United States of America, as represented by the Secretary of Agriculture · Granted Tue May 23 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 18 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 11654157

    Methods and compositions for cancer therapies that include delivery of halogenated thymidines and thymidine phosphorylase inhibitors in combination with radiation

    Shuttle Pharmaceuticals, Inc. · Granted Tue May 23 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 18 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 11654128

    Methods and compositions for treating ectoparasite infestations

    Nuvo Pharmaceuticals (Ireland) Designated Activity Company · Granted Tue May 23 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 18 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 11655307

    Anti-doublecortin-like kinase 1 antibodies and methods of use

    The Board of Regents of the University of Oklahoma · Granted Tue May 23 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 18 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 11654145

    Combination therapy involving diaryl macrocyclic compounds

    TURNING POINT THERAPEUTICS, INC. · Granted Tue May 23 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 18 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. CA 3235096

    METHODES DE TRAITEMENT DE L'ANEMIE CAUSEE PAR UNE MALADIE RENALE

    DISC MEDICINE INC [US] · Granted Thu May 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed May 20 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 11660274

    Dosage forms and methods for enantiomerically enriched or pure bupropion

    AXSOME THERAPEUTICS, INC. · Granted Tue May 30 2023 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 25 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2043?

1,718 published patents in our USPTO index have expiration dates falling in calendar year 2043.