Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2040

Annual patent cliff calendar for 2040 — US pharmaceutical patents by expiration date.

Patents
1,866

Quick answer

1,866 indexed pharmaceutical patents have expiration dates in 2040. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 10874709

    Conjugate of salicylic acid and peptide

    CAREGEN CO., LTD. · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 10874748

    Intervention for tendinopathy

    Montefiore Medical Center · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 10875907

    Filovirus antibody

    The Government of the United States, as represented by the Secretary of the Army · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 10875911

    High affinity human antibodies to human angiopoietin-2

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 10875913

    Methods of treatment using activatable anti-EGFR antibodies

    CytomX Therapeutics, Inc. · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 10875920

    Antibodies and molecules that immunospecifically bind to BTN1A1 and the therapeutic uses thereof

    The Board of Regents of the University of Texas System · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 10876118

    Method for expression of small antiviral RNA molecules with reduced cytotoxicity within a cell

    The Regents of the University of California · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 10874676

    Methods for treating subjects with Prader-Willi syndrome or Smith-Magenis syndrome

    ESSENTIALIS, INC. · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 10874687

    Highly active compounds against COVID-19

    Atea Pharmaceuticals, Inc. · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 10881708

    Ang (1-7) derivative oligopeptides for the treatment of pain

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Jan 05 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 31 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 10881684

    Artificial invaplex formulated with deacylated lipopolysaccharide

    United States Government as represented by the Secretary of the Army · Granted Tue Jan 05 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 31 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 10881646

    Methods and compositions for treating non-ERK MAPK pathway inhibitor-resistant cancers

    Biomed Valley Discoveries, Inc. · Granted Tue Jan 05 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 31 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 10881644

    Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs

    Lutonix, Inc. · Granted Tue Jan 05 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 31 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 10881086

    Genetically modified mouse whose genome comprises a humanized CD274 gene

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jan 05 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 31 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 10881104

    Arthropod control composition, formulation, and method

    TYRATECH, INC. · Granted Tue Jan 05 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 31 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 10881630

    Creatine oral supplementation using creatine hydrochloride salt

    BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA · Granted Tue Jan 05 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 31 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 10881658

    Methods for treating Huntington's disease

    PTC THERAPEUTICS, INC. · Granted Tue Jan 05 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 31 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 10881653

    Tricyclic compounds and their use in the treatment of cancer

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jan 05 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 31 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 10881660

    Fatty liver disease treatment using glucocorticoid and mineralocorticoid receptor antagonists

    Corcept Therapeutics Incorporated · Granted Tue Jan 05 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 31 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 10881666

    Combination pharmaceutical agents as RSV inhibitors

    Enanta Pharmaceuticals, Inc. · Granted Tue Jan 05 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 31 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 10881669

    Inhibitors of the plasmodial surface anion channel as antimalarials

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jan 05 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 31 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 10881691

    Cell preparations for extemporaneous use, useful for healing and rejuvenation in vivo

    RegenLab USA LLC · Granted Tue Jan 05 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 31 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 10882895

    Nucleic acid encoding angiopoietin-2 specific Tie2 receptor

    United Kingdom Research and Innovation · Granted Tue Jan 05 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 31 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 10881738

    Oligomer-beta blocker conjugates

    Nektar Therapeutics · Granted Tue Jan 05 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 31 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 10881722

    Epizootic hemorrhagic disease vaccine

    The United States of America, as represented by the Secretary of Agriculture · Granted Tue Jan 05 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 31 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 10881696

    Network-based microbial compositions and methods

    Seres Therapeutics, Inc. · Granted Tue Jan 05 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 31 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 10881689

    Materials and methods for engineering cells and uses thereof in immuno-oncology

    CRISPR THERAPEUTICS AG · Granted Tue Jan 05 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 31 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 10881698

    Diagnosis and treatment for respiratory tract diseases

    United States Government as represented by the Department of Veterans Affairs · Granted Tue Jan 05 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 31 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 10881714

    Methods and compositions for oral administration of proteins

    Oramed Ltd. · Granted Tue Jan 05 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 31 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 10883980

    Methods and compositions for inhibiting hepatitis E virus

    THE TRUSTEES OF PRINCETON UNIVERSITY · Granted Tue Jan 05 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 31 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 10883994

    Identification of cancer stem cells markers and use of same for diagnosis and treatment

    TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. · Granted Tue Jan 05 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 31 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 10883107

    Polynucleotide agents targeting factor XII (hageman factor) (F12) and methods of use thereof

    Alnylam Pharmaceuticals, Inc. · Granted Tue Jan 05 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 31 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 10883104

    Compositions and methods for modulating apolipoprotein (a) expression

    Ionis Pharmaceuticals, Inc. · Granted Tue Jan 05 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 31 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 10883119

    Methods and compositions for delivery of biologics

    Sangamo Therapeutics, Inc. · Granted Tue Jan 05 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 31 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 10881720

    Nanoparticles for immune stimulation

    The Board of Regents of the University of Texas System · Granted Tue Jan 05 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 31 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 10883094

    Transposase polypeptides and uses thereof

    The Board of Regents of the University of Texas System · Granted Tue Jan 05 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 31 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 10882903

    Methods and compositions for treating an alphavirus infection

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Jan 05 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 31 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 10881748

    Nitroxide containing amyloid binding agents for imaging and therapeutic uses

    The Regents of the University of California · Granted Tue Jan 05 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 31 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 10881742

    Factor VIII chimeric and hybrid polypeptides, and methods of use thereof

    BIOVERATIV THERAPEUTICS INC. · Granted Tue Jan 05 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 31 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 10881735

    Phase change nanodroplet conjugates for targeted delivery

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Jan 05 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 31 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 10883117

    Adeno-associated virus variants and methods of use thereof

    The Regents of the University of California · Granted Tue Jan 05 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 31 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 10882886

    Adeno-associated virus polynucleotides, polypeptides and virions

    THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (WASHINGTON DC) · Granted Tue Jan 05 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 31 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2040?

1,866 published patents in our USPTO index have expiration dates falling in calendar year 2040.