Wednesday, June 10, 2026
🇺🇸 FDA

Intelligence · Patents

Patents expiring in 2040

Annual patent cliff calendar for 2040 — US pharmaceutical patents by expiration date.

Patents
1,866

Quick answer

1,866 indexed pharmaceutical patents have expiration dates in 2040. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 10869911

    Chimeric protein

    AUTOLUS LIMITED · Granted Tue Dec 22 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 17 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 10870673

    β-D-2′-deoxy-2′-α-fluoro-2′-β-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment

    Atea Pharmaceuticals, Inc. · Granted Tue Dec 22 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 17 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 10869846

    N-acetylcysteine amide (NAC amide) in the treatment of diseases and conditions associated with oxidative stress

    SENTIENT LIFESCIENCES, INC. · Granted Tue Dec 22 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 17 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 10870842

    Stabilized alpha-galactosidase and uses thereof

    Protalix Ltd. · Granted Tue Dec 22 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 17 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 10870679

    Modulation of structured polypeptide specificity

    BicycleRD Limited · Granted Tue Dec 22 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 17 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 10869856

    Substituted phenylpyrrolecarboxamides with therapeutic activity in HIV

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Dec 22 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 17 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 10870645

    Bicyclic [4,6,0] hydroxamic acids as HDAC inhibitors

    Valo Early Discovery, Inc. · Granted Tue Dec 22 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 17 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. EP 3752616

    ZUSAMMENSETZUNGEN UND VERFAHREN ZUR GENEDITIERUNG DURCH TARGETING VON FIBRINOGEN-ALPHA

    CRISPR THERAPEUTICS AG [CH] · Granted Wed Dec 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Tue Dec 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. LT 3254695

    COMBINATION THERAPY INVOLVING ANTIBODIES AGAINST CLAUDIN 18.2 FOR TREATMENT OF CANCER

    ASTELLAS PHARMA INC [JP] · Granted Mon Dec 28 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Sun Dec 23 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 10875894

    Multimeric bicyclic peptide ligands

    BicycleTx Limited · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 10878964

    Predictive control model for the artificial pancreas using past predictions

    The Regents of the University of California · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 10876134

    Gene therapy for juvenile batten disease

    BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 10876123

    Chimeric antigen receptors targeting B-cell maturation antigen

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 10876119

    Reduced size self-delivering RNAI compounds

    Phio Pharmaceuticals Corp. · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 10876116

    Anti-ARID3a treatments for inflammatory disorders

    The Board of Regents of the University of Oklahoma · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 10876114

    Methods and means for efficient skipping of at least one of the following exons of the human Duchenne muscular dystrophy gene: 43, 46, 50-53

    BIOMARIN TECHNOLOGIES B.V. · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 10875915

    Anti-CXCR5 antibodies and compositions and uses thereof

    The Regents of the University of California · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 10876003

    Class of stable heptamethine cyanine fluorophores and biomedical applications thereof

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 10875912

    EGFL6 specific monoclonal antibodies and methods of their use

    The Board of Regents of the University of Texas System · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 10875893

    Cell-reactive, long-acting, or targeted compstatin analogs and related compositions and methods

    Apellis Pharmaceuticals, Inc. · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 10875903

    Bifunctional fusion proteins to inhibit angiogenesis in tumor microenvironment and to activate adaptive immune responses and the genes and uses thereof

    CHINA PHARMACEUTICAL UNIVERSITY · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 10875860

    Azaindenoisoquinoline compounds and uses thereof

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 10875885

    β-d-2′-deoxy-2′-α-fluoro-2′-β-c-substituted-2-modified-n6-substituted purine nucleotides for HCV treatment

    Atea Pharmaceuticals, Inc. · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 10874752

    MIBG analogs and uses thereof

    BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 10874768

    Drug eluting medical device

    Covidien LP · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 10874840

    Preparation comprising exanatide for delivery into a lumen of the intestinal tract

    Rani Therapeutics, LLC · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 10875839

    Somatostatin modulators and uses thereof

    CRINETICS PHARMACEUTICALS, INC. · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 10874727

    Inducible regulatory t-cell generation for hematopoietic transplants

    Regents of the University of Minnesota · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 10874719

    Nucleotide phosphate dissipation as a treatment for vascular disorders

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 10874745

    Antimicrobial peptides and methods of treating gram-negative pathogens: polar and non-polar face analogs

    The Regents of the University of Colorado, a Body Corporate · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 10874743

    IRAK degraders and uses thereof

    Kymera Therapeutics, Inc. · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 10875855

    Inhibitors of influenza viruses replication

    Vertex Pharmaceuticals Incorporated · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 10874678

    Selective high-affinity polydentate ligands and methods of making such

    The Regents of the University of California · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 10874672

    Methods for treating Huntington's disease

    PTC THERAPEUTICS, INC. · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 10874659

    Iloperidone metabolite for use in the treatment of psychiatric disorders

    VANDA PHARMACEUTICALS INC. · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 10874638

    Methods and compositions for modulating hormone levels

    Ligand Pharmaceuticals Incorporated · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 10874643

    5HT agonists for treating disorders

    The Regents of the University of California · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 10874635

    Tocotrienol compositions

    First Tech International Limited · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 10874648

    Methods for the administration of certain VMAT2 inhibitors

    Neurocrine Biosciences, Inc. · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 10874631

    Altertoxin II as a selective inhibitor of Ewing family of tumor cells

    The Board of Regents of the University of Texas System · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 10874334

    Methods and systems for quantification of blood-brain barrier permeation of glycosylated peptides

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 10874610

    Extracellular vesicle-based diagnostics and engineered exosomes for targeted therapeutics against cancer

    Northwestern University · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 10874622

    Dual assembly nanoparticles

    The Board of Regents of the University of Texas System · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 10874092

    Humanized skeletal muscle

    Regents of the University of Minnesota · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 10874609

    ß-cyclodextrin-based star-shaped polymer, a preparation method therefor and an integrated unimolecular micelle system for diagnosis and treatment thereof

    South China University of Technology · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 10874633

    Pharmaceutical compositions and methods for countering chemotherapy induced cardiotoxicity

    Auransa Inc. · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 10874649

    2-spiro-5- and 6-hydroxamic acid indanes as HDAC inhibitors

    Valo Early Discovery, Inc. · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 10874673

    Inhibitors of influenza viruses replication

    Vertex Pharmaceuticals Incorporated · Granted Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 24 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2040?

1,866 published patents in our USPTO index have expiration dates falling in calendar year 2040.

Drug approvals, clinical trials, M&A, event intelligence, and company updates — weekly.

Customize topics & region
Topics
Region

No spam. Unsubscribe anytime. See our privacy policy.