Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2040

Annual patent cliff calendar for 2040 — US pharmaceutical patents by expiration date.

Patents
1,866

Quick answer

1,866 indexed pharmaceutical patents have expiration dates in 2040. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 10842743

    Modified hyaluronic acid hydrogels and proteins for the time-controlled release of biologic agents

    The Regents of the University of California · Granted Tue Nov 24 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 19 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 10844376

    Structurally-enhanced miRNA inhibitor S-TuD

    GeneDesign, Inc. · Granted Tue Nov 24 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 19 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 10844379

    Conjugated antisense compounds and their use

    Ionis Pharmaceuticals, Inc. · Granted Tue Nov 24 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 19 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 10851173

    Anti-OX40 antibodies and methods of using the same

    The Board of Regents of the University of Texas System · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 10851115

    Heterocyclic compounds as RSV inhibitors

    Enanta Pharmaceuticals, Inc. · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 10851112

    Anti-HCMV virus compound

    Medshine Discovery Inc. · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 10851093

    Tyrosine kinase inhibitors

    Rigel Pharmaceuticals, Inc. · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 10851158

    Biomarkers related to interleukin-33 (IL-33)-mediated diseases and uses thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 10850011

    Hydrogel membrane for adhesion prevention

    The Board of Regents of the University of Texas · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 10849935

    Method to suppress the systemic toxicity of chemotherapeutic drugs

    UNITED ARAB EMIRATES UNIVERSITY · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 10849988

    Hydrogel for engineered immune response to D-chirality peptides

    The Regents of the University of California · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 10851102

    Imidazole and triazole containing bicyclic compounds as JAK inhibitors

    Theravance Biopharma R&D IP, LLC · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 10851101

    Compounds for treating spinal muscular atrophy

    PTC THERAPEUTICS, INC. · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 10851146

    Method for preparing liraglutide intermediate polypeptide

    AMPHASTAR NANJING PHARMACEUTICALS INC · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 10849970

    Antibody evolution immunogens

    The Government of the United States of America as represented by the Secretary of the Deptartment of Health and Human Services · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 10849965

    H3.3 CTL peptides and uses thereof

    The Regents of the University of California · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 10849867

    Methods and compositions for treating conditions associated with an abnormal inflammatory response

    First Wave Bio, Inc. · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 10849878

    Agent exhibiting anti-stress, anxiolytic and anti-depression activity, and composition based thereon

    OBSHCHESTVO S OGRANICHENNOY OTVETSTVENNOSTYU “NORMOFARM” · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 10849883

    Benzopyrazole compounds and analogues thereof

    BioCryst Pharmaceuticals, Inc. · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 10849891

    Formulations of pimavanserin

    ACADIA Pharmaceuticals Inc. · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 10849902

    Medicament for treating heart failure

    Takeda Pharmaceutical Company Limited · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 10849908

    Corticotropin releasing factor receptor antagonists

    SPRUCE BIOSCIENCES, INC. · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 10849896

    Sortilin-binding small molecules for increasing glucose uptake

    United States Government as represented by the Department of Veterans Affairs · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 10849910

    Use of H3K9me3 modulation for enhancing cognitive function

    The Regents of the University of California · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 10849917

    Antisense-induced exon exclusion in type VII collagen

    Sarepta Therapeutics, Inc. · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 10849885

    Methods for dosing an orally active 1,2,4-oxadiazole for nonsense mutation suppression therapy

    PTC THERAPEUTICS, INC. · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 10849911

    Low dose compositions of Aramachol salts

    GALMED RESEARCH AND DEVELOPMENT LTD · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 10849912

    Method of sensitizing cancer cells to the cytotoxic effects of apoptosis inducing ligands in cancer treatment

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 10849960

    Synergistic combination of IL-4, interferon gamma, and interferon alpha in treating ovarian cancer

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 10851058

    Histone deacetylase inhibitors

    BIOMARIN PHARMACEUTICAL INC. · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 10851072

    Inhibitors of Rho/MRTF/SRF-mediated gene transcription and methods for use of the same

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 10849869

    Compositions and methods for treating chronic inflammation and inflammatory diseases

    Infirst Healthcare Limited · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 10851110

    Heterocyclic inhibitors of PTPN11

    The Board of Regents of the University of Texas System · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 10849975

    Multivalent vaccines for rabies virus and filoviruses

    The United States of America, as Represented by the Secretary, Department of Health and Human Services Services · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 10849936

    Compositions and methods for C. difficile treatment

    Regents of the University of Minnesota · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 10851377

    Methods and compositions for treating a proprotein convertase subtilisin kexin (PCSK9) gene-associated disorder

    Alnylam Pharmaceuticals, Inc. · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 10849982

    C3-carbon linked glutarimide degronimers for target protein degradation

    C4 THERAPEUTICS, INC. · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 10851103

    Valbenazine salts and polymorphs thereof

    Neurocrine Biosciences, Inc. · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 10852220

    Methods and devices for high throughput purification

    THE TRUSTEES OF PRINCETON UNIVERSITY · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 10851104

    Valbenazine salts and polymorphs thereof

    Neurocrine Biosciences, Inc. · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 10851463

    Membrane template synthesis of microtube engines

    The Regents of the University of California · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 10851088

    Polymorphs and solid forms of a pyrimidinylamino-pyrazole compound, and methods of production

    DENALI THERAPEUTICS INC. · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 10851367

    Tissue-specific genome engineering using CRISPR-Cas9

    The Regents of the University of California · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 10851412

    Cell potency assay for therapeutic potential

    Fate Therapeutics, Inc. · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 10851358

    Engineered meganucleases specific for recognition sequences in the hepatitis B virus genome

    Precision BioSciences, Inc. · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 10849875

    Cancer specific lipid targeted peptidomimetics

    The Board of Regents of the University of Texas System · Granted Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 26 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 2020376145

    GADOLINIUM BEARING PCTA-BASED CONTRAST AGENTS

    BRACCO IMAGING SPA [IT] · Granted Thu Dec 03 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Nov 28 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 10858323

    HDAC inhibitors for the treatment of diabetic peripheral neuropathy

    Regenacy Pharmaceuticals, Inc. · Granted Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2040?

1,866 published patents in our USPTO index have expiration dates falling in calendar year 2040.