Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2040

Annual patent cliff calendar for 2040 — US pharmaceutical patents by expiration date.

Patents
1,866

Quick answer

1,866 indexed pharmaceutical patents have expiration dates in 2040. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 10745704

    Compositions and methods for inhibiting expression of CD274/PD-L1 gene

    Alnylam Pharmaceuticals, Inc. · Granted Tue Aug 18 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 13 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 10745471

    Method of treating osteoarthritis with an antibody to NGF

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Aug 18 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 13 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 10745397

    1-Substituted 1,2,3,4-tetrahydro-1,7-naphthyridin-8-amine derivatives and their use as EP4 receptor antagonists

    Takeda Pharmaceutical Company Limited · Granted Tue Aug 18 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 13 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 10744232

    Antimicrobial catheters

    The Board of Regents of the University of Texas System · Granted Tue Aug 18 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 13 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 10744144

    Pharmaceutical formulation

    Semnur Pharmaceuticals, Inc. · Granted Tue Aug 18 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 13 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 10744104

    Neprilysin inhibitors

    Theravance Biopharma R&D IP, LLC · Granted Tue Aug 18 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 13 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 10744230

    Biomimetic hybrid gel compositions and methods of use

    BIOACTIVE REGENERATIVE THERAPEUTICS, INC. · Granted Tue Aug 18 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 13 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 10745701

    Methods of identifying and treating poor-prognosis cancers

    THE TRUSTEES OF PRINCETON UNIVERSITY · Granted Tue Aug 18 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 13 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 10743542

    Preparation method and use of an atomic-state fluid iodine and its derived nano-iodine

    CHINESE ACADEMY OF AGRICULTURAL ENGINEERING PLANNING & DESIGN · Granted Tue Aug 18 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 13 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 10744103

    Methods and compositions for treating conditions associated with an abnormal inflammatory responses

    First Wave Bio, Inc. · Granted Tue Aug 18 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 13 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 10744154

    Galactose-pronged polysaccharides in a formulation for antifibrotic therapies

    GALECTIN THERAPEUTICS, INC. · Granted Tue Aug 18 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 13 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 10744116

    Detection and treatment of anti-PD-1 therapy resistant metastatic melanomas

    The Regents of the University of California · Granted Tue Aug 18 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 13 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 10744152

    Application of Asarum total polysaccharides in preparation of medicine for treating cough

    THE FIRST AFFILIATTED HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY · Granted Tue Aug 18 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 13 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 10744173

    Traditional Chinese medicine compositions for alleviating stress

    INFINITUS (CHINA) COMPANY LTD. · Granted Tue Aug 18 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 13 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 10744193

    Immunogenic RSV polypeptides

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Aug 18 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 13 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 10745352

    Dual function molecules for histone deacetylase inhibition and ataxia telangiectasia mutated activation and methods of use thereof

    Shuttle Pharmaceuticals, Inc. · Granted Tue Aug 18 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 13 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 10745366

    Therapeutic compounds

    ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY · Granted Tue Aug 18 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 13 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 10745392

    Benzenesulfonamide compounds and their use as therapeutic agents

    Xenon Pharmaceuticals Inc. · Granted Tue Aug 18 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 13 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 10745394

    8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists

    Theravance Biopharma R&D IP, LLC · Granted Tue Aug 18 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 13 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 10745453

    Compositions and methods for enhancing visual function

    The Regents of the University of California · Granted Tue Aug 18 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 13 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 10745464

    Aldehyde tags, uses thereof in site-specific protein modification

    The Regents of the University of California · Granted Tue Aug 18 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 13 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 10745413

    Commercially viable synthesis of cantharidin and bioactive cantharidin derivatives

    Verrica Pharmaceuticals Inc. · Granted Tue Aug 18 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 13 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 10745416

    Macrocyclic compounds for treating disease

    TURNING POINT THERAPEUTICS, INC. · Granted Tue Aug 18 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 13 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 10745420

    Tetrahydropyrido[4,3-d]pyrimidine inhibitors of ATR kinase

    The Board of Regents of the University of Texas System · Granted Tue Aug 18 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 13 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. CA 3129357

    FORMULATIONS PHARMACEUTIQUES LIQUIDES DE CONJUGUES PTH

    ASCENDIS PHARMA BONE DISEASES AS [DK] · Granted Thu Aug 20 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Aug 15 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 10752598

    Aryldiazepine derivatives as RSV inhibitors

    Enanta Pharmaceuticals, Inc. · Granted Tue Aug 25 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 20 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 10752607

    Polymorphs of N-[(6-cyano-2-fluoro)-3-methoxyphenyl)methyl]-3-(methoxymethyl)-1-({4-[(2-oxopyridin-1-yl)methyl]phenyl}methyl)pyrazole-4-carboxamide as kallikrein inhibitors

    KalVista Pharmaceuticals Limited · Granted Tue Aug 25 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 20 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 10752599

    Crystalline (2S,4R)-5-(5′-chloro-2′-fluoro-[1,1′-biphenyl]-4-yl)-2-(ethoxymethyl)-4-(3-hydroxyisoxazole-5-carboxamido)-2-methylpentanoic acid and uses thereof

    Theravance Biopharma R&D IP, LLC · Granted Tue Aug 25 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 20 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 10752882

    Compositions and methods for treating retinal diseases

    The Regents of the University of California · Granted Tue Aug 25 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 20 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 10752701

    Stabilized formulations containing anti-PCSK9 antibodies

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Aug 25 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 20 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 10752690

    Biologically active molecule conjugates, reagents and methods of manufacture, and therapeutic uses

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Aug 25 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 20 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 10750943

    Imaging-guided creating and monitoring of retinal vascular occlusive disease

    Northwestern University · Granted Tue Aug 25 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 20 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 10751348

    Formulations of testosterone and methods of treatment therewith

    The Board of Regents of the University of Texas System · Granted Tue Aug 25 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 20 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 10752581

    4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase

    The Regents of the University of California Santa · Granted Tue Aug 25 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 20 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 10751428

    Functionalized magnetic nanoparticles and use in imaging amyloid deposits and neurofibrillary tangles

    The Regents of the University of California · Granted Tue Aug 25 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 20 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 10751347

    Compositions comprising acidic extracts of mastic gum and uses thereof for treating optic neuropathy

    REGENERA PHARMA LTD. · Granted Tue Aug 25 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 20 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 10751302

    Polymorphic and amorphous forms of (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide

    PTC THERAPEUTICS, INC. · Granted Tue Aug 25 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 20 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 10751339

    Substituted aminopyrimidine compounds and methods of use

    SUNSHINE LAKE PHARMA CO., LTD. · Granted Tue Aug 25 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 20 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 10751317

    Methods and compositions for increasing the potency of antifungal agents

    PACIFIC NORTHWEST RESEARCH INSTITUTE · Granted Tue Aug 25 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 20 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 10751332

    Heterocyclic inhibitors of ERK1 and ERK2 and their use in the treatment of cancer

    Asana BioSciences, LLC · Granted Tue Aug 25 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 20 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 10751383

    Doses and methods for administering telavancin

    Cumberland Pharmaceuticals Inc. · Granted Tue Aug 25 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 20 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 10751408

    Compositions and methods for making and using thermostable immunogenic formulations with increased compatibility of use as vaccines against one or more pathogens

    The Regents of the University of Colorado, a Body Corporate · Granted Tue Aug 25 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 20 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 10751409

    Immunogenic compositions and uses thereof

    The Board of Regents of the University of Texas System · Granted Tue Aug 25 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 20 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 10751419

    Method for synthesis of reactive conjugate clusters

    Ionis Pharmaceuticals, Inc. · Granted Tue Aug 25 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 20 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 10752623

    Heteroaryl-substituted sulfonamide compounds and their use as sodium channel inhibitors

    Xenon Pharmaceuticals Inc. · Granted Tue Aug 25 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 20 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 10752699

    Anti-APOBEC3 antibodies and methods of making and using

    Regents of the University of Minnesota · Granted Tue Aug 25 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 20 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 10752656

    Anti-microbial supramolecular structures

    Northwestern University · Granted Tue Aug 25 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 20 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 10752651

    Antimicrobial compounds, compositions, and uses thereof

    Lakewood Amedex, Inc. · Granted Tue Aug 25 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 20 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2040?

1,866 published patents in our USPTO index have expiration dates falling in calendar year 2040.