Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2040

Annual patent cliff calendar for 2040 — US pharmaceutical patents by expiration date.

Patents
1,866

Quick answer

1,866 indexed pharmaceutical patents have expiration dates in 2040. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 10683504

    Serpina1 iRNA compositions and methods of use thereof

    Alnylam Pharmaceuticals, Inc. · Granted Tue Jun 16 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 11 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 10682425

    Engineered B lymphocytes and compositions having micro-RNA and methods for making and using them

    The Regents of the University of California · Granted Tue Jun 16 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 11 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 10683530

    Detection of oligosaccharides

    BIOMARIN PHARMACEUTICAL INC. · Granted Tue Jun 16 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 11 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 10683277

    Triazole derivatives as P2Y14 receptor antagonists

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jun 16 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 11 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 10683330

    Campylobacter immunogenic compositions and uses thereof

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Jun 16 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 11 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 10683354

    Antibody-drug conjugates comprising anti-prolactin receptor (PRLR) antibodies and methods of use thereof to kill PRLR-expressing cells

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jun 16 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 11 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 10683500

    UNA oligomers having reduced off-target effects in gene silencing

    ARCTURUS THERAPEUTICS, INC. · Granted Tue Jun 16 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 11 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 10683366

    Methods and compositions for treatment of atherosclerosis

    The Board of Regents of the University of Texas System · Granted Tue Jun 16 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 11 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 10689413

    Composition enriched in single isomer of NUC-1031 and preparation method and use thereof

    BrightGene Bio-Medical Technology Co., Ltd. · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 10689397

    ULK1 inhibitors and methods using same

    SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 10689400

    Macrocycle kinase inhibitors

    TURNING POINT THERAPEUTICS, INC. · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 10689338

    Psychotropic agents and uses thereof

    LB PHARMACEUTICALS INC. · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 10689357

    N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and use thereof

    Northwestern University · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 10689373

    1,2-substituted cyclopentanes as orexin receptor antagonists

    Takeda Pharmaceutical Company Limited · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 10689719

    Bifidobacterium longum

    PrecisionBiotics Group Limited · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 10689422

    Recombinant polypeptide construct comprising multiple enterotoxigenic Escherichia coli fimbrial subunits

    United States of America as represented by the Secretary of the Air Force · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 10689377

    KRas G12C inhibitors

    Mirati Therapeutics, Inc. · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 10689392

    Anti-cancer compounds targeting ral GTPases and methods of using the same

    The Regents of the University of Colorado, a Body Corporate · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 10688102

    Combination treatment for migraine and other pain

    AXSOME THERAPEUTICS, INC. · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 10689347

    Substituted heterocyclyl derivatives as CDK inhibitors

    Aurigene Discovery Technologies Limited · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 10687520

    Generation and correction of a humanized mouse model with a deletion of dystrophin exon 44

    The Board of Regents of the University of Texas System · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 10688181

    Cancer treatment combinations

    The Regents of the University of California · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 10689595

    Synthesis and use of omega-hydroxylated polyunsaturated fatty acids

    The Regents of the University of California · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 10689717

    Methods and compositions for targeted single-stranded cleavage and targeted integration

    Sangamo Therapeutics, Inc. · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 10689436

    Human antibodies to influenza hemagglutinin

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 10689443

    Humanized monoclonal antibodies and methods of use for the diagnosis and treatment of colon and pancreas cancer

    PRECISION BIOLOGICS, INC. · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 10689456

    Anti-CD70 chimeric antigen receptors

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 10688453

    System and method for droplet formation and manipulation using ferrofluids

    The Regents of the University of California · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 10688174

    Method of conferring a protective immune response to norovirus

    Takeda Vaccines, Inc. · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 10689375

    Compounds and their methods of use

    Agios Pharmaceuticals, Inc. · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 10688160

    Enzymes and methods for cleaving N-glycans from glycoproteins

    The Regents of the University of California · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 10689414

    Therapeutically active compounds and their methods of use

    Agios Pharmaceuticals, Inc. · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 10688063

    Treating and/or preventing insulin-resistance related weight gain

    The United States Government as Represented by the Department of Veterans Affairs of General Counsel- PSG IV (024) · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 10688090

    Vilazodone inclusion complexes, compositions and preparation thereof

    SUNSHINE LAKE PHARMA CO., LTD. · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 10688056

    Implantable medical devices for extended release of therapeutic agents

    Nano Precision Medical, Inc. · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 10688185

    Pharmaceutical compositions comprising meloxicam

    AXSOME THERAPEUTICS, INC. · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 10688080

    Compositions, methods of use, and methods of treatment

    The Regents of the University of California · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 10688099

    Methods for modulating the amount of RNA transcripts

    PTC THERAPEUTICS, INC. · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 10688172

    HPV particles and uses thereof

    Aura Biosciences, Inc. · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 10688184

    Methods and compositions for self-regulated release of active pharmaceutical ingredient

    Acurx Pharmaceuticals, Inc. · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 10688203

    Methods of performing brachytherapy

    The Board of Regents of the University of Texas System · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 10688183

    Stable aqueous formulations of adalimumab

    Coherus BioSciences, Inc. · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 10688195

    Polymyxin B-coated nanoparticles

    Northwestern University · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 10688285

    Spinal subpial gene delivery system

    The Regents of the University of California · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 10689346

    Human plasma kallikrein inhibitors

    BioCryst Pharmaceuticals, Inc. · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 10689352

    Solid state forms of trisodium valsartan: sacubitril

    TEVA PHARMACEUTICALS INTERNATIONAL GMBH · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 10689419

    Process for the preparation of cyclic depsipeptides

    OnKure, Inc. · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 10689646

    Treatment of genetic disorders associated with DNA repeat instability

    BIOMARIN TECHNOLOGIES B.V. · Granted Tue Jun 23 2020 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 18 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2040?

1,866 published patents in our USPTO index have expiration dates falling in calendar year 2040.