Wednesday, June 10, 2026
🇺🇸 FDA

Intelligence · Patents

Patents expiring in 2039

Annual patent cliff calendar for 2039 — US pharmaceutical patents by expiration date.

Patents
1,782

Quick answer

1,782 indexed pharmaceutical patents have expiration dates in 2039. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 10221226

    LEDGF peptides and formulations thereof for treatment of degenerative disorders

    The Regents of the University of Colorado, a Body Corporate · Granted Tue Mar 05 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 28 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 10221244

    Anti-CSF1R antibody and anti PD-1 antibody combination therapy for cancer

    Five Prime Therapeutics, Inc. · Granted Tue Mar 05 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 28 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. WO 2019043176

    INHIBITEUR DE L'HISTONE-DÉSACÉTYLASE EN ASSOCIATION AVEC UN AGENT ANTIMÉTABOLITE POUR LA CANCÉROTHÉRAPIE

    4SC AG [DE] · Granted Thu Mar 07 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Mar 02 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. DK 2928905

    FREMGANGSMÅDE TIL OPRENSNING AF TERAPEUTISKE PROTEINER

    CSL BEHRING GMBH [DE] · Granted Mon Mar 11 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Sun Mar 06 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 10227630

    Antimicrobial agents from microbial genomes

    The Regents of the University of California · Granted Tue Mar 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 10226516

    Process, tube and device for the preparation of wound healant composition

    RegenLab USA LLC · Granted Tue Mar 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 10227565

    Generating hepatocytes

    The Regents of the University of California · Granted Tue Mar 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 10227610

    Methods and compositions for enhancing nuclease-mediated gene disruption

    Sangamo Therapeutics, Inc. · Granted Tue Mar 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 10227323

    Glucosylceramide synthase inhibitors for the treatment of diseases

    BIOMARIN PHARMACEUTICAL INC. · Granted Tue Mar 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 10227395

    Monoclonal antibodies that neutralize anthrax protective antigen (PA) toxin

    The United States of America as Represented by the Secretary, Dept. of Health and Human Services · Granted Tue Mar 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 10227352

    Substituted 4-methyl-pyrrolo[1,2-A]pyrimidine-8-carboxamide compounds and uses thereof for modulating glucocerebrosidase activity

    Northwestern University · Granted Tue Mar 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 10227302

    Ionizable cationic lipid for RNA delivery

    ARCTURUS THERAPEUTICS, INC. · Granted Tue Mar 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 10226535

    Auristatin compounds and conjugates thereof

    Mersana Therapeutics, Inc. · Granted Tue Mar 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 10226526

    Vaccines for human papilloma virus and methods for using the same

    Inovio Pharmaceuticals, Inc. · Granted Tue Mar 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 10226523

    Clostridium difficile vaccine and methods of use

    The Board of Regents of the University of Oklahoma · Granted Tue Mar 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 10226521

    Genetically modified Yersinia as vaccines against Yersinia species

    ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY · Granted Tue Mar 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 10227290

    Glycosphingolipids for use in modulating immune responses

    The Regents of the University of California · Granted Tue Mar 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 10226534

    Semi-solid delivery systems

    Regents of the University of Minnesota · Granted Tue Mar 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 10226488

    Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof

    UNIVERSITY OF CONNECTICUT · Granted Tue Mar 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 10226485

    Multipotent adult stem cells and methods for isolation

    Regents of the University of Minnesota · Granted Tue Mar 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 10226512

    Method for treating heart failure with preserved ejection fraction by administering human relaxin-2

    Relaxera Pharmazeutische Gesellschaft mbH & Co. KG · Granted Tue Mar 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 10226468

    Quinazolines and azaquinazolines as dual inhibitors of RAS/RAF/MEK/ERK and PI3K/AKT/PTEN/mTOR pathways

    Asana BioSciences, LLC · Granted Tue Mar 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 10226454

    Crystalline form of a 4-[2-(2-fluorophenoxymethyl)phenyl]piperidine compound

    Theravance Biopharma R&D IP, LLC · Granted Tue Mar 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 10226452

    Benzoxazolone derivatives as acid ceramidase inhibitors, and their use as medicaments

    The Regents of the University of California · Granted Tue Mar 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 10226420

    Methods of eye treatment using therapeutic compositions containing dipyridamole

    O.D. Ocular Discovery Ltd. · Granted Tue Mar 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 10226518

    Ubiquitinylated proteins

    Providence Health & Science—Oregon · Granted Tue Mar 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 10227312

    Glucosylceramide synthase inhibitors for the treatment of diseases

    BIOMARIN PHARMACEUTICAL INC. · Granted Tue Mar 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 10227362

    Anti-pulmonary tuberculosis nitroimidazole derivative

    Medshine Discovery Inc. · Granted Tue Mar 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 10227567

    Isolation and use of solid tumor stem cells

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Mar 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 10226426

    Suspension containing nano-cocrystal and manufacturing method

    Takeda Pharmaceutical Company Limited · Granted Tue Mar 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 10226472

    Methods for the treatment of breast cancer

    Syndax Pharmaceuticals, Inc. · Granted Tue Mar 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 10226487

    Derivation and self-renewal of lsl1+ cells and uses thereof

    IsletOne AB · Granted Tue Mar 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 10226520

    Compositions and methods for enterohemorrhagic Escherichia coli (EHEC) vaccination

    THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXA SYSTEM · Granted Tue Mar 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 10227611

    Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

    The Regents of the University of California · Granted Tue Mar 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. WO 2019048531

    NANOPARTICULES MODIFIÉES PAR L'ALBUMINE PORTANT UN LIGAND DE CIBLAGE

    ABBVIE DEUTSCHLAND [DE] · Granted Thu Mar 14 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Mar 09 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. CA 3075215

    INHIBITEUR DE L'HISTONE DESACETYLASE EN ASSOCIATION AVEC UN MODULATEUR DE POINT DE CONTROLE IMMUNITAIRE POUR LA CANCEROTHERAPIE

    4SC AG [DE] · Granted Thu Mar 14 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Mar 09 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 2019076525

    THERAPY INVOLVING ANTIBODIES AGAINST CLAUDIN 18.2 FOR TREATMENT OF CANCER

    GANYMED PHARMACEUTICALS GMBH [DE] · Granted Thu Mar 14 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Mar 09 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 10233142

    Metabolites of (1R-trans)-N-[[2-(2,3-dihydro-4-benzofuranyl)cyclopropyl]methyl]propanamide

    VANDA PHARMACEUTICALS INC. · Granted Tue Mar 19 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 14 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 10232044

    Controlled release aural pressure modulator compositions and methods for the treatment of OTIC disorders

    The Regents of the University of California · Granted Tue Mar 19 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 14 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 10232042

    Conjugates of an anti-TNF-alpha antibody

    Nektar Therapeutics · Granted Tue Mar 19 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 14 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 10232035

    Conditionally replication deficient herpes virus and use thereof in vaccines

    The Regents of the University of Colorado, a Body Corporate · Granted Tue Mar 19 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 14 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 10232041

    Combination of lenalidomide and polypeptide construct, and uses thereof

    TEVA PHARMACEUTICALS PTY LTD · Granted Tue Mar 19 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 14 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 10231998

    Method for chemoselection

    The Regents of the University of California · Granted Tue Mar 19 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 14 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 10231988

    Patatin-like phospholipase domain containing 3 (PNPLA3) iRNA compositions and methods of use thereof

    Alnylam Pharmaceuticals, Inc. · Granted Tue Mar 19 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 14 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 10231949

    Inhibition of cancer cell motility

    Northwestern University · Granted Tue Mar 19 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 14 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 10231984

    Oligomer-foscarnet conjugates

    Nektar Therapeutics · Granted Tue Mar 19 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 14 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 10231983

    Use of ACTH in assessment and prophylactic treatment of hypokalemia associated with glucocorticoid receptor modulator treatment of Cushing's syndrome patients

    Corcept Therapeutics Incorporated · Granted Tue Mar 19 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 14 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 10231947

    Isochroman compounds and methods of use thereof

    ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY · Granted Tue Mar 19 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 14 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2039?

1,782 published patents in our USPTO index have expiration dates falling in calendar year 2039.

Drug approvals, clinical trials, M&A, event intelligence, and company updates — weekly.

Customize topics & region
Topics
Region

No spam. Unsubscribe anytime. See our privacy policy.