Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2039

Annual patent cliff calendar for 2039 — US pharmaceutical patents by expiration date.

Patents
1,782

Quick answer

1,782 indexed pharmaceutical patents have expiration dates in 2039. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 10450372

    Anti-thyroglobulin T cell receptors

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 10450384

    Compositions of alpha-1 antitrypsin fusion molecules

    The Regents of the University of Colorado · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 10450565

    Alpha-1 antitrypsin (AAT) RNAi agents, compositions including AAT RNAi agents, and methods of use

    Arrowhead Pharmaceuticals, Inc. · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 10450585

    Delivery methods and compositions for nuclease-mediated genome engineering

    Sangamo Therapeutics, Inc. · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. CA 3097087

    COMBINAISON COMPRENANT UN INHIBITEUR DE HDAC, UN INHIBITEUR DE LAG-3 ET UN INHIBITEUR DE PD-1 OU UN INHIBITEUR DE PD-L1 POUR LE TRAITEMENT DU CANCER

    4SC AG [DE] · Granted Thu Oct 24 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Oct 19 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 10456476

    Method involving 1-benzotriazolyl carbonate esters of poly(ethylene glycol)

    Nektar Therapeutics · Granted Tue Oct 29 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 10457703

    Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof

    Enanta Pharmaceuticals, Inc. · Granted Tue Oct 29 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 10457670

    Isoindoline-1-one derivatives as cholinergic muscarinic M1 receptor positive alloesteric modulator activity for the treatment of Alzheimers disease

    Takeda Pharmaceutical Company Limited · Granted Tue Oct 29 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 10456439

    NK3 agonist for use in the treatment of a patient suffering from atrial arrhythmia or fibrillation

    ACADEMISCH MEDISCH CENTRUM · Granted Tue Oct 29 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 10456390

    Combinations comprising MABA compounds and corticosteroids

    Almirall, S.A. · Granted Tue Oct 29 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 10456373

    Agent exhibiting anti-stress, anxiolytic and anti-depression activity, and composition based thereon

    OBSHCHESTVO S OGRANICHENNOY OTVETSTVENNOSTYU “NORMOFARM” · Granted Tue Oct 29 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 10457654

    Therapeutic compounds and methods of use thereof

    Xenon Pharmaceuticals Inc. · Granted Tue Oct 29 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 10456473

    Lipid compositions

    ARBUTUS BIOPHARMA CORPORATION · Granted Tue Oct 29 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 10456461

    Construction of West Nile virus and dengue virus chimeras for use in a live virus vaccine to prevent disease caused by West Nile virus

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Oct 29 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 10457676

    Capsazepine analogs for the treatment of cancer and other proliferative diseases

    The Board of Regents of the University of Texas System · Granted Tue Oct 29 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 10457662

    Substituted amides for treating and preventing cancer

    The Board of Regents of the University of Texas System · Granted Tue Oct 29 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 10457945

    UNA oligomers for therapeutics with prolonged stability

    ARCTURUS THERAPEUTICS, INC. · Granted Tue Oct 29 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 10457725

    Methods of treating skin cancer by administering a PD-1 inhibitor

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Oct 29 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 10457726

    Antibody and antigen-binding fragment compositions targeting cell surface antigens in tumors and methods of use thereof

    UNIVERSITY OF CONNECTICUT · Granted Tue Oct 29 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 10457701

    Sialic acid analogs

    Ultragenyx Pharmaceutical Inc. · Granted Tue Oct 29 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 10456412

    Lipid extraction processes

    AKER BIOMARINE ANTARCTIC AS · Granted Tue Oct 29 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 10456408

    Methods for treating subjects with Prader-Willi syndrome or Smith-Magenis syndrome

    ESSENTIALIS, INC. · Granted Tue Oct 29 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 10456380

    Compositions and methods of treating muscular dystrophy with thromboxane-A2 receptor antagonists

    Cumberland Pharmaceuticals Inc. · Granted Tue Oct 29 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 10456406

    Use of a PPAR-δ agonist for reducing loss of muscle strength, muscle mass, or type I muscle fibers in an immobilized limb

    VTV THERAPEUTICS LLC · Granted Tue Oct 29 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 10456404

    Targeting cGMP-related phosphodiesterases to reduce cyst formation in cystic kidney disease, and related materials and methods

    United States Government as represented by the Department of Veterans Affairs · Granted Tue Oct 29 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 10456392

    Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators

    Corcept Therapeutics Incorporated · Granted Tue Oct 29 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 10456346

    Cosmetic formulations for topical applications containing erythropoietin-derived molecules

    ASC REGENITY LIMITED · Granted Tue Oct 29 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 10456340

    Liquid-impregnated nonwoven fabric which contains zinc oxide-containing cellulose fibers

    LENZING AKTIENGESELLSCHAFT · Granted Tue Oct 29 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 10455849

    Method for the preparation of a protein peptide, a protein peptide and use thereof

    INFINITUS (CHINA) COMPANY LTD. · Granted Tue Oct 29 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 10456292

    Compositions and methods relating to an occlusive polymer hydrogel

    Revolution Contraceptives LLC · Granted Tue Oct 29 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 10456333

    Dental adhesive

    KURARAY NORITAKE DENTAL INC. · Granted Tue Oct 29 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 10456448

    PTD-SMAD7 therapeutics

    The Regents of the University of Colorado, a Body Corporate · Granted Tue Oct 29 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 10457745

    Anti-complement C1s antibodies

    Bioverativ USA Inc. · Granted Tue Oct 29 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 10456471

    Pharmaceutical compositions comprising meloxicam

    AXSOME THERAPEUTICS, INC. · Granted Tue Oct 29 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 24 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. CA 3097885

    PROCEDES ET COMPOSITIONS D'EPUISEMENT DE LYMPHOCYTES T CYTOTOXIQUES

    CRISPR THERAPEUTICS AG [CH] · Granted Thu Oct 31 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Oct 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. CA 3098014

    CELLULES CAR-T ANTI-BCMA POUR DEPLETION DE CELLULES PLASMATIQUES

    CRISPR THERAPEUTICS AG [CH] · Granted Thu Oct 31 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Oct 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 10464918

    Process of making somatostatin modulators

    CRINETICS PHARMACEUTICALS, INC. · Granted Tue Nov 05 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 31 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 10463029

    Rodent model of steel syndrome

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Nov 05 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 31 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 10463697

    Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy

    Iovance Biotherapeutics, Inc. · Granted Tue Nov 05 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 31 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 10463748

    Human antibodies to S. aureus Hemolysin A toxin

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Nov 05 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 31 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 10464989

    Polypeptides, cells, and methods involving engineered CD16

    Regents of the University of Minnesota · Granted Tue Nov 05 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 31 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 10464994

    Recombinant clusterin and use thereof in the treatment and prevention of disease

    The Board of Regents of the University of Texas System · Granted Tue Nov 05 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 31 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 10465004

    Frizzled receptor antibodies for treatment of cancer

    TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. · Granted Tue Nov 05 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 31 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 10466259

    Synthetic antigen compositions for detecting anti-phosphatidylethanolamine antibodies

    Northwestern University · Granted Tue Nov 05 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 31 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 10465227

    Microbial testing devices, methods of making microbial testing devices and methods of identifying novel antimicrobial drug candidates

    The Board of Regents of the University of Texas System · Granted Tue Nov 05 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 31 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 10466249

    Methods and reagents for analyzing protein-protein interfaces

    Revolution Medicines, Inc. · Granted Tue Nov 05 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 31 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 10465194

    Complement component iRNA compositions and methods of use thereof

    Alnylam Pharmaceuticals, Inc. · Granted Tue Nov 05 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 31 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 10464993

    Compositions and methods for immunomodulation in an organism

    UNIVERSITY OF CONNECTICUT · Granted Tue Nov 05 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 31 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2039?

1,782 published patents in our USPTO index have expiration dates falling in calendar year 2039.