Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2039

Annual patent cliff calendar for 2039 — US pharmaceutical patents by expiration date.

Patents
1,782

Quick answer

1,782 indexed pharmaceutical patents have expiration dates in 2039. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 10442911

    Dendritic macroporous hydrogels prepared by crystal templating

    The Board of Regents of the University of Texas System · Granted Tue Oct 15 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 10 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 10443049

    Active low molecular weight variants of angiotensin converting enzyme 2 (ACE2)

    Northwestern University · Granted Tue Oct 15 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 10 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 10443073

    Sin Nombre virus full-length M segment-based DNA vaccines

    The Government of the United States, as represented by the Secretary of the Army · Granted Tue Oct 15 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 10 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 10443076

    Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

    The Regents of the University of California · Granted Tue Oct 15 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 10 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 10444237

    Anti-pancreatic cancer monoclonal antibody and use thereof

    NANJING MARKERLINE BIOMEDICAL TECHNOLOGY CO., LTD. · Granted Tue Oct 15 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 10 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 10442852

    Methods and compositions for treatment of symptoms associated with intracranial hemorrhage

    The Board of Regents of the University of Texas System · Granted Tue Oct 15 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 10 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 10442788

    Hepatitis B antiviral agents

    Enanta Pharmaceuticals, Inc. · Granted Tue Oct 15 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 10 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 10441645

    MSLN targeting DNA vaccine for cancer immunotherapy

    Vaximm AG · Granted Tue Oct 15 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 10 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 10441552

    Anti-microbial composition comprising cannabinoids

    AXIM BIOTECHNOLOGIES. INC. · Granted Tue Oct 15 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 10 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 10441567

    Methods and compositions for modulating hormone levels

    Ligand Pharmaceuticals Incorporated · Granted Tue Oct 15 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 10 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 10442846

    Hepcidin analogues and uses thereof

    Protagonist Therapeutics, Inc. · Granted Tue Oct 15 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 10 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. WO 2019200238

    COMBINAISONS COMPRENANT UN OLIGONUCLÉOTIDE DE TYPE CPG-C ET UN INHIBITEUR D'HISTONE DÉSACÉTYLASE POUR LE TRAITEMENT DU CANCER

    DYNAVAX TECH CORP [US] · Granted Thu Oct 17 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Oct 12 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. CA 3096765

    PRODUITS DE COMBINAISON PHARMACEUTIQUE COMPRENANT UN INHIBITEUR D'HISTONE DESACETYLASE (HDAC) ET UN AGONISTE DE TLR7 ET/OU UN AGONISTE DE TLR8 POUR LE TRAITEMENT DU CANCER

    4SC AG [DE] · Granted Thu Oct 17 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Oct 12 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. WO 2019197609

    ANTICORPS DIRIGÉS CONTRE BST1 POUR PRÉVENIR OU TRAITER LE SYNDROME MYÉLODYSPLASIQUE

    BERLIN CHEMIE AG [DE] · Granted Thu Oct 17 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Oct 12 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 10450285

    2-benzoylaminobenzamide derivatives as Bcl-3 inhibitors

    University College Cardiff Consultants Limited · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 10451610

    Prediction of response to PARP inhibitors and combinational therapy targeting C-MET and PARP1

    The Board of Regents of the University of Texas System · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 10450382

    Anti-complement C1s antibodies

    Bioverativ USA Inc. · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 10450371

    Monoclonal antibody and antigens for diagnosing and treating lung disease and injury

    United States Government as represented by the Department of Veterans Affairs · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 10449232

    Puma protein expression vector and use thereof in gene therapy

    The Regents of the University of California · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 10449231

    Compositions and methods for dengue virus chimeric constructs in vaccines

    The Government of the United States of America as represented by the Secretary of the Deptartment of Health and Human Services · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 10449191

    Treatment of prostate cancer

    Takeda Pharmaceutical Company Limited · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 10449171

    Compositions and methods for diagnosis and treatment of metabolic syndrome

    The United States of America, as represented by Secretary of the Navy · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 10448634

    Composition with high antimicrobial activity and low toxicity

    The Regents of the University of California · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 10449152

    Drug loaded microspheres for post-operative chronic pain

    Covidien LP · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 10448637

    Inhibitors of GRB2-associated binding protein 1 (GAB1) and methods of treating cancer using the same

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 10449129

    Encapsulates of salicylic acid and polysalicylic acid derivatives

    Biocogent, LLC · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 10449170

    Compositions for diagnosis and treatment of type 2 diabetes

    The United States of America, as represented by Secretary of the Navy · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 10449176

    Treatment of circadian rhythm disorders

    VANDA PHARMACEUTICALS INC. · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 10449184

    Pharmaceutical compositions of therapeutically active compounds

    Agios Pharmaceuticals, Inc. · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 10449185

    Formulations of pimavanserin

    ACADIA Pharmaceuticals Inc. · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 10449178

    Glucocorticoid receptor modulators to treat pancreatic cancer

    Corcept Therapeutics Incorporated · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 10449182

    Sorafenib derivatives as p21 inhibitors

    The Regents of the University of California · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 10449203

    Tianeptine oxalate salts and polymorphs

    TONIX PHARMA LIMITED · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 10449210

    Prodrug compounds and their uses

    Ligand Pharmaceuticals Incorporated · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 10449207

    Acyclic nucleoside phosphonate diesters

    The Regents of the University of California · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 10449230

    Polymyxin derived cell penetrating scaffolds

    The Regents of the University of California · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 10449241

    Interferon-β production modulating Listeria strains and methods for using same

    The Regents of the University of California · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 10449254

    Ionic liquids for transdermal drug delivery

    Arizona Board of Regents c/o Northern Arizona University · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 10449321

    Gas delivery devices

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 10450275

    Compounds and methods for treating cancer, neurological disorders, ethanol withdrawal, anxiety, depression, and neuropathic pain

    The Board of Regents of the University of Texas System · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 10450280

    Tetrazolones as a carboxylic acid bioisosteres

    Rigel Pharmaceuticals, Inc. · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 10450355

    Lectins and uses thereof

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 10450306

    Isoxazole analogs as FXR agonists and methods of use thereof

    Enanta Pharmaceuticals, Inc. · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 10450340

    3′-deamino-3′-(2″-pyrroline-1″-yl)-5-imino-13-deoxyanthracyclines and methods of preparation

    Monopar Therapeutics Inc. · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 10450358

    Platelet-derived growth factor B mutant, preparation method therefor and use thereof

    Institute of Biotechnology, Academy of Military Medical Sciences, China · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 10450352

    Engineered polypeptides for antigen delivery

    The Board of Regents of the University of Texas System · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 10450364

    Hyperimmunized egg product for treatment of necrotic enteritis in poultry

    United States of America as represented by the Secretary of the Air Force · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 10450572

    Androgen receptor variant inhibitors and methods of using

    Regents of the University of Minnesota · Granted Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 17 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2039?

1,782 published patents in our USPTO index have expiration dates falling in calendar year 2039.