Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2039

Annual patent cliff calendar for 2039 — US pharmaceutical patents by expiration date.

Patents
1,782

Quick answer

1,782 indexed pharmaceutical patents have expiration dates in 2039. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 10407374

    Compositions and methods for ameliorating CNS inflammation, psychosis, delirium, PTSD or PTSS

    The Regents of the University of California · Granted Tue Sep 10 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 05 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 10407416

    Kappa opioid agonists and uses thereof

    Nektar Therapeutics · Granted Tue Sep 10 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 05 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 10407405

    Nuclear transport modulators and uses thereof

    Karyopharm Therapeutics Inc. · Granted Tue Sep 10 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 05 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 10407403

    Preparation method of cobimetinib

    Suzhou Miracpharma Technology Co., Ltd. · Granted Tue Sep 10 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 05 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 10407414

    Mannose derivatives for treating bacterial infections

    Vertex Pharmaceuticals Incorporated · Granted Tue Sep 10 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 05 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 10407457

    Pyrrolopyrimidine nucleosides and analogs thereof

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Sep 10 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 05 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 10407476

    Methods and compositions for treating hemophilia

    Sangamo Therapeutics, Inc. · Granted Tue Sep 10 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 05 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 10407445

    Hepatitis C virus inhibitors

    Enanta Pharmaceuticals, Inc. · Granted Tue Sep 10 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 05 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 10407468

    Methods for synthesizing α4β7 peptide antagonists

    Protagonist Therapeutics, Inc. · Granted Tue Sep 10 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 05 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 10407508

    Compositions and methods for increasing protein half-life in a serum

    Nanjing Legend Biotech Co., Ltd · Granted Tue Sep 10 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 05 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 10407485

    Murine anti-NY-ESO-1 T cell receptors

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Sep 10 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 05 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 10407488

    Therapy for treatment or prevention of conditions associated with bleeding or hypocoagulation

    The Regents of the University of California · Granted Tue Sep 10 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 05 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 10407495

    Bispecific antibody fragments for neurological disease proteins and methods of use

    ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY · Granted Tue Sep 10 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 05 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 10407503

    Fully human antibodies and fragments recognizing human c-Met

    The Regents of the University of California · Granted Tue Sep 10 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 05 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 10407678

    Compositions for modulating expression of C9ORF72 antisense transcript

    Ionis Pharmaceuticals, Inc. · Granted Tue Sep 10 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 05 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 10407679

    Apolipoprotein C3 (APOC3) iRNA compositions and methods of use thereof

    Alnylam Pharmaceuticals, Inc. · Granted Tue Sep 10 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 05 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 10407680

    Compounds and methods for reducing Tau expression

    Ionis Pharmaceuticals, Inc. · Granted Tue Sep 10 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 05 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 10407697

    Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

    The Regents of the University of California · Granted Tue Sep 10 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 05 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 10407735

    Schlap-1 ncRNA and uses thereof

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Sep 10 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 05 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 10415038

    Compounds and methods for modulating TMPRSS6 expression

    Ionis Pharmaceuticals, Inc. · Granted Tue Sep 17 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 10415037

    Compositions and methods for silencing hepatitis B virus gene expression

    ARBUTUS BIOPHARMA CORPORATION · Granted Tue Sep 17 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 10414758

    Compounds and method for treating autoimmune diseases

    Rigel Pharmaceuticals, Inc. · Granted Tue Sep 17 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 10414753

    Amide compounds and method for making and using

    Rigel Pharmaceuticals, Inc. · Granted Tue Sep 17 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 10414740

    Glutaminase inhibitors and method of use

    Agios Pharmaceuticals, Inc. · Granted Tue Sep 17 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 10414761

    Cyclopropanamine compound and use thereof

    Takeda Pharmaceutical Company Limited · Granted Tue Sep 17 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 10414732

    Polymorphic compounds and uses thereof

    Aldeyra Therapeutics, Inc. · Granted Tue Sep 17 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 10414725

    Pyrrolomycins and methods of using the same

    BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA · Granted Tue Sep 17 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 10413620

    Light-emitting versions of the monoclonal antibody to C3D (MAB 3D29) for imaging

    The Regents of the University of Colorado, a Body Corporate · Granted Tue Sep 17 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 10413603

    Compositions, methods and uses for improved human papilloma virus constructs

    The Regents of the University of Colorado, a Body Corporate · Granted Tue Sep 17 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 10413580

    Compositions comprising Cyclocarya paliurus extract and preparation method and uses thereof

    INFINITUS (CHINA) COMPANY LTD. · Granted Tue Sep 17 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 10413602

    Fungal immunogens and related materials and methods

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Sep 17 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 10413566

    Thixotropic oxidized cellulose solutions and medical applications thereof

    Covidien LP · Granted Tue Sep 17 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 10413541

    Oxabicycloheptanes and oxabicycloheptenes for the treatment of depressive and stress disorders

    Lixte Biotechnology, Inc. · Granted Tue Sep 17 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 10413565

    Nanostructures for modulating intercellular communication and uses thereof

    Northwestern University · Granted Tue Sep 17 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 10413577

    Compositions and methods for promoting growth of beneficial microbes to treat or prevent disease or prolong life

    The Regents of the University of California · Granted Tue Sep 17 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 10413527

    Substituted phenylpyrrolecarboxamides with therapeutic activity in HIV

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Sep 17 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 10414655

    Stem cell, bone, tissue and nerve scaffolding from discrete carbon nanotubes

    MOLECULAR REBAR DESIGN, LLC · Granted Tue Sep 17 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 10413540

    Glucocorticoid receptor modulators to treat cervical cancer

    Corcept Therapeutics Incorporated · Granted Tue Sep 17 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 10413616

    Hydrogel prodrug for treatment

    Viking Scientific, Inc. · Granted Tue Sep 17 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 10414656

    Discrete carbon nanotubes with targeted oxidation levels and formulations thereof

    MOLECULAR REBAR DESIGN, LLC · Granted Tue Sep 17 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 10415015

    Engineered artificial antigen presenting cells for tumor infiltrating lymphocyte expansion

    Iovance Biotherapeutics, Inc. · Granted Tue Sep 17 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 10415044

    Adeno-associated virus vectors encoding modified G6PC and uses thereof

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Sep 17 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 10415881

    Method and device for freeze-drying drug liposomes powder assisted by variable-frequency alternating-current electric field

    South China University of Technology · Granted Tue Sep 17 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 10415040

    Nucleic acid amphiphiles and nanostructures

    Regents of the University of Minnesota · Granted Tue Sep 17 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 10414771

    Compounds useful for inhibiting metastasis from cancer and methods using same

    Alliance Discovery, Inc. · Granted Tue Sep 17 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 10416163

    Method and treatment of recurring endometrial cancer with an inhibitor of USP14

    Regents of the University of Minnesota · Granted Tue Sep 17 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 10413548

    Methods and compositions for the inhibition of Pin1

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Sep 17 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 10416174

    Diagnosis and prognosis for chronic fatigue syndrome

    ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY · Granted Tue Sep 17 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2039?

1,782 published patents in our USPTO index have expiration dates falling in calendar year 2039.