Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2039

Annual patent cliff calendar for 2039 — US pharmaceutical patents by expiration date.

Patents
1,782

Quick answer

1,782 indexed pharmaceutical patents have expiration dates in 2039. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 2019153441

    MATERIALS AND METHODS FOR TREATMENT OF AUTOSOMAL DOMINANT RETINITIS PIGMENTOSA

    CASEBIA THERAPEUTICS LLP [GB] · Granted Thu May 23 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed May 18 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 2019151500

    OPHTHALMIC VISCOELASTIC COMPOSITIONS

    BAUSCH & LOMB [US] · Granted Thu May 23 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed May 18 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 10300134

    Vaccine formulations and methods of preparation and use thereof

    Tejas Discovery and Research, LLC · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 10300113

    Targeted therapeutic proteins

    BIOMARIN PHARMACEUTICAL INC. · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 10300074

    Use of inhibitor of apoptosis protein (IAP) antagonists in HIV therapy

    SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 10300106

    Autophagy-inducing peptide analogs

    The Board of Regents of the University of Texas System · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 10301317

    Inhibitors of ERK and methods of use

    Kura Oncology, Inc. · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 10300080

    Methods and compounds to inhibit enveloped virus release

    Northwestern University · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 10300130

    Cytomegalovirus vaccines and methods of production

    THE TRUSTEES OF PRINCETON UNIVERSITY · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 10300073

    Use of CDK9 and BRD4 inhibitors to inhibit inflammation

    The Regents of the University of California · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 10301314

    Compounds and methods for the prevention and treatment of tumor metastasis and tumorigenesis

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 10301292

    Bicyclic compound

    Takeda Pharmaceutical Company Limited · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 10300072

    Cyclohexylamine derivatives having β2 adrenergic agonist and M3 muscarinic antagonist activities

    Almirall, S.A. · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 10302602

    Process of conducting high throughput testing high performance liquid chromatography

    Vertex Pharmaceuticals Incorporated · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 10300149

    Compositions for enhancing transport of molecules into cells

    Sarepta Therapeutics, Inc. · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 10300036

    Compositions and methods for treating and preventing lung injury

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 10300107

    Compositions and methods for CaMKII inhibitors and uses thereof

    The Regents of the University of Colorado, a Body Corporate · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 10300010

    Methods for delivering entanercept preparations into a lumen of the intestinal tract using a swallowable drug delivery device

    Rani Therapeutics, LLC · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 10300095

    AAV mediated exendin-4 gene transfer to salivary glands to protect subjects from diabetes or obesity

    The United States of America as Represented by the Secretary, Dept. of Health and Human Services · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 10301248

    Compositions and methods comprising resveratrol

    Biocogent, LLC · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 10300123

    Synthetic peptide-based marker vaccine and diagnostic system for effective control of porcine reproductive and respiratory syndrome (PRRS)

    United Biomedical, Inc. · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 10300117

    Methods and compositions for improved cognition

    The Regents of the University of California · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 10300047

    Crystalline forms of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid for the treatment of disease

    PTC THERAPEUTICS, INC. · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 10300152

    Enzyme-encapsulated nanoparticle platform

    The Regents of the University of California · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 10300043

    Method for treating a gastrointestinal disorder in a mammal using bacteroides thetaiotaomicron and compositions thereof

    The Regents of the University of California · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 10300115

    Methods and compositions for modulating immune tolerance

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 10300151

    Methods and systems for noninvasive fluorescence-based functional imaging of kidneys

    The Board of Regents of the University of Texas System · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 10301626

    Catalytic strands of minimal hammerhead ribozymes and methods of using the same

    The Regents of the University of California · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 10301369

    Nucleic acids encoding targeted therapeutic lysosomal enzyme fusion proteins

    BIOMARIN PHARMACEUTICAL INC. · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 10301621

    Multifunctional RNA nanoparticles and methods of use

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 10301365

    Met e 1 tropomyosin variants for use in allergen-specific immunotherapy

    The Regents of the University of California · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 10301377

    Middle east respiratory syndrome coronavirus immunogens, antibodies, and their use

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 10300027

    Effective sensitizing dose of a gelled immunomodulating topical composition

    Phio Pharmaceuticals Corp. · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 10301255

    Hepatitis B antiviral agents

    Enanta Pharmaceuticals, Inc. · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 10301320

    Compositions and methods of modulating 15-PGDH activity

    The Board of Regents of the University of Texas System · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 10301380

    Anti-jagged 1/jagged 2 cross-reactive antibodies, activatable anti-jagged antibodies and methods of use thereof

    CytomX Therapeutics, Inc. · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 10301371

    Cyclic monomer and dimer peptides having integrin antagonist activity

    Protagonist Therapeutics, Inc. · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 10301323

    Histone deacetylase inhibitors

    BIOMARIN PHARMACEUTICAL INC. · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 10301622

    Quantification and spatio-temporal tracking of a target using a spherical nucleic acid (SNA)

    Northwestern University · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 10301304

    Selective inhibitor of phosphatidylinositol 3-kinase-gamma

    Vertex Pharmaceuticals Incorporated · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 10300150

    Virion-derived nanospheres for selective delivery of therapeutic and diagnostic agents to cancer cells

    Aura Biosciences, Inc. · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 10301393

    Methods of treating multiple sclerosis using anti-CD20 antibodies

    VACCINEX, INC. · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 10301651

    Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

    The Regents of the University of California · Granted Tue May 28 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 23 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 2019161472

    NEW ANTIBACTERIAL COMPOUNDS

    ACRAF [IT] · Granted Thu May 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed May 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. IL 265680

    Dimeric contrast agents

    BRACCO IMAGING SPA [IT] · Granted Thu May 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed May 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. HR P20190642

    ARIPIPRAZOLE PRODRUG COMPOSITIONS

    ALKERMES PHARMA IRELAND LTD [IE] · Granted Fri May 31 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Thu May 26 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 10308591

    Preparation of (R,R)-fenoterol and (R,R)- or (R,S)-fenoterol analogues and their use in treating congestive heart failure

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jun 04 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 30 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 10307481

    CD37 immunotherapeutics and uses thereof

    Aptevo Research and Development LLC · Granted Tue Jun 04 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 30 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2039?

1,782 published patents in our USPTO index have expiration dates falling in calendar year 2039.