Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2039

Annual patent cliff calendar for 2039 — US pharmaceutical patents by expiration date.

Patents
1,782

Quick answer

1,782 indexed pharmaceutical patents have expiration dates in 2039. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 10280307

    Class of stable heptamethine cyanine fluorophores and biomedical applications thereof

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue May 07 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 02 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 10279040

    Agonist antibodies that bind human CD137 and uses thereof

    Compass Therapeutics LLC · Granted Tue May 07 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 02 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 10281475

    Systems and methods to identify and treat subjects at risk for obstetrical complications

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue May 07 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 02 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 10280158

    Immune adjustment compound, use thereof and pharmaceutical composition comprising same

    SuZhou Connect Biopharmaceuticals, Inc. · Granted Tue May 07 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 02 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 10278957

    Opioid agonist peptides and uses thereof

    Protagonist Therapeutics, Inc. · Granted Tue May 07 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 02 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 10280120

    Zirconia composition, zirconia pre-sintered body and zirconia sintered body, and dental product

    KURARAY NORITAKE DENTAL INC. · Granted Tue May 07 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 02 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 10278977

    Methods for treating hypersomnolence

    Umecrine Cognition AB · Granted Tue May 07 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 02 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 10279010

    Methods and compositions for modulating myofibroblast activities

    The Regents of the University of California · Granted Tue May 07 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 02 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 10279029

    Immunogenic compositions and uses thereof

    The Board of Regents of the University of Texas System · Granted Tue May 07 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 02 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 10278982

    Method of treating heterotopic ossification

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue May 07 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 02 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 10279015

    TPP-1 formulations and methods for treating CLN2 disease

    BIOMARIN PHARMACEUTICAL INC. · Granted Tue May 07 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 02 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 10278374

    Genetically modified mice and engraftment

    REGENERON PHARMACEUTICALS, INC. · Granted Tue May 07 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 02 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 10280414

    Stabilized α-galactosidase and uses thereof

    Protalix Ltd. · Granted Tue May 07 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 02 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 10279023

    Mucin-associated surface protein as a vaccine against chagas disease

    The Board of Regents of the University of Texas System · Granted Tue May 07 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 02 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 10280218

    Antibodies binding to BMP4, and uses thereof

    ACADEMISCH MEDISCH CENTRUM · Granted Tue May 07 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 02 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 10279039

    Agonist antibodies that bind human CD137 and uses thereof

    Compass Therapeutics LLC · Granted Tue May 07 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 02 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 10279176

    Method and apparatus for increasing absorption of medications and cosmeceuticals through the skin of the user

    FIRST STEP HOLDINGS, LLC · Granted Tue May 07 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 02 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 10279042

    One-step processing of hydrogels for mechanically robust and chemically desired features

    The Board of Regents of the University of Texas System · Granted Tue May 07 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 02 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 10280175

    Hepatitis B antiviral agents

    Enanta Pharmaceuticals, Inc. · Granted Tue May 07 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 02 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 10280197

    Discovery of the first selective C5A receptor 2 (C5L2/C5AR2) ligands

    The Regents of the University of California · Granted Tue May 07 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 02 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 10280415

    Human cystathionine β-synthase variants and methods of production thereof

    The Regents of the University of Colorado, a Body Corporate · Granted Tue May 07 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 02 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 10280423

    Compositions and methods for modulating complement factor B expression

    Ionis Pharmaceuticals, Inc. · Granted Tue May 07 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 02 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 10285913

    Dental polymerizable composition, dental temporary cement, dental filling material, denture liner, and dental tissue conditioner

    KURARAY NORITAKE DENTAL INC. · Granted Tue May 14 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 09 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 10285937

    Method and apparatus for treating ear infections

    Try This First, Inc. · Granted Tue May 14 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 09 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 10285388

    Non-human animals having a disruption in a C9ORF72 locus

    REGENERON PHARMACEUTICALS, INC. · Granted Tue May 14 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 09 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 10285962

    Glutarate compounds for treating ischemia-reperfusion injuries

    The Regents of the University of California · Granted Tue May 14 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 09 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 10286050

    Multi-epitope TARP peptide vaccine and uses thereof

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue May 14 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 09 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 10285988

    Compounds for treatment of fibrosis diseases

    Curegenix, Inc. · Granted Tue May 14 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 09 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 10285980

    Compositions for an orally active 1,2,4-oxadiazole for the treatment of disease

    PTC THERAPEUTICS, INC. · Granted Tue May 14 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 09 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 10285978

    Heterocycle analogs of CAI-1 as agonists of quorum sensing in vibrio

    THE TRUSTEES OF PRINCETON UNIVERSITY · Granted Tue May 14 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 09 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 10287606

    Genomic engineering of pluripotent cells

    Fate Therapeutics, Inc. · Granted Tue May 14 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 09 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 10287350

    Chimeric antigen receptors targeting CD-19

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue May 14 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 09 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 10287340

    Anti-HIV domain antibodies and method of making and using same

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue May 14 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 09 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 10287295

    TGF-β inhibitors

    Rigel Pharmaceuticals, Inc. · Granted Tue May 14 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 09 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 10287284

    Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof

    VTV THERAPEUTICS LLC · Granted Tue May 14 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 09 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 10286064

    Cationic lipid vaccine compositions and methods of use

    THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SEC. OF THE DEPT. OF HEALTH AND HUMAN SERVICES · Granted Tue May 14 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 09 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 10286079

    Modified cytotoxins and their therapeutic use

    The Regents of the University of California · Granted Tue May 14 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 09 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 10285996

    Compositions comprising triterpenoids

    REGENERA PHARMA LTD. · Granted Tue May 14 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 09 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 10285956

    N-(2-aminoethyl) ethanolamine (AEEA) and analogs to treat hypertrophic scarring and liposomal topical delivery

    The Board of Regents of the University of Texas System · Granted Tue May 14 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 09 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 10285952

    Nanoparticles leverage biological membranes to target pathogens for disease treatment and diagnosis

    The Regents of the University of California · Granted Tue May 14 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 09 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 10285945

    Formation of stable submicron peptide or protein particles by thin film freezing

    The Board of Regents of the University of Texas System · Granted Tue May 14 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 09 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 10286011

    Compositions and methods for transplantation of colon microbiota

    Regents of the University of Minnesota · Granted Tue May 14 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 09 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 10285986

    Compounds and anti-tumor NQO1 substrates

    The Board of Regents of the University of Texas System · Granted Tue May 14 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 09 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 10286036

    Protocol for treatment of lupus nephritis

    AURINIA PHARMACEUTICALS INC. · Granted Tue May 14 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 09 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 10285940

    Multicomponent, internally structured nanoemulsions and methods of production

    The Regents of the University of California · Granted Tue May 14 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 09 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 10285935

    Non-invasive method for direct delivery of therapeutics to the spinal cord in the treatment of spinal cord pathology

    United States Department of Veteran Affairs · Granted Tue May 14 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 09 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 10285964

    Fatty-acid based particles

    ATRIUM MEDICAL CORPORATION · Granted Tue May 14 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 09 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 10286016

    Compositions and methods for treating gonorrhea

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue May 14 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 09 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2039?

1,782 published patents in our USPTO index have expiration dates falling in calendar year 2039.