Wednesday, June 10, 2026
🇺🇸 FDA

Intelligence · Patents

Patents expiring in 2039

Annual patent cliff calendar for 2039 — US pharmaceutical patents by expiration date.

Patents
1,782

Quick answer

1,782 indexed pharmaceutical patents have expiration dates in 2039. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 10273299

    Antibodies to tumor endothelial marker 8

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 10273218

    BCL-3 inhibitors

    University College Cardiff Consultants Limited · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 10272113

    Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy

    Iovance Biotherapeutics, Inc. · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 10272146

    Purified plasmodium and vaccine compositions

    Sanaria Inc. · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 10272069

    Methods of treating muscular dystrophy

    BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE OF THE UNIVERSITY OF NEVADA, RENO · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 10272099

    Tumor-selective combination therapy

    The Board of Regents of the University of Texas System · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 10272139

    Process, tube and device for the preparation of wound healant composition

    RegenLab USA LLC · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 10273225

    Pyrazines as modulators of GPR6

    Takeda Pharmaceutical Company Limited · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 10273189

    Zirconia composition, zirconia pre-sintered body and zirconia sintered body, and dental product

    KURARAY NORITAKE DENTAL INC. · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 10273482

    dsRNA for treating viral infection

    Arrowhead Pharmaceuticals, Inc. · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 10272046

    Pharmaceutical composition and administrations thereof

    Vertex Pharmaceuticals Incorporated · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 10273477

    Therapeutic compositions

    Alnylam Pharmaceuticals, Inc. · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 10273333

    Substituted polyesters by thiol-ene modification: rapid diversification for therapeutic protein stabilization

    The Regents of the University of California · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 10273281

    CD80 extracellular domain polypeptides and their use in cancer treatment

    Five Prime Therapeutics, Inc. · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 10273292

    Non-HIV vaccine antigen from the vaginal microbiota capable of inducing a mucosal neutralizing protective antibody response against HIV infection

    B Cell Design SAS · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 10273291

    Focused evolution of HIV-1 neutralizing antibodies revealed by crystal structures and deep sequencing

    THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, OFFICE OF TECHNOLOGY TRANSFER—NATIONAL INSTITUTES OF HEALTH · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 10273288

    Neutralizing antibodies to Ebola virus glycoprotein and their use

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 10273245

    1-arylcarbonyl-4-oxy-piperidine compounds useful for the treatment of neurodegenerative diseases

    Takeda Pharmaceutical Company Limited · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 10273233

    Inhibitors of influenza viruses replication

    Vertex Pharmaceuticals Incorporated · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 10273244

    Substituted hexahydropyrrolo[3,4-b]pyrroles and hexahydrocyclopenta[c]pyrroles as dopamine receptor modulators

    Indivior UK Limited · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 10273228

    Hepatitis B viral assembly effectors

    ASSEMBLY BIOSCIENCES, INC. · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 10272607

    Manufacturing of small film strips

    Aquestive Therapeutics, Inc. · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 10272163

    Factor VIII mutation repair and tolerance induction

    THE UNITED STATES OF AMERICA REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 10272184

    Hydrogel membrane for adhesion prevention

    The Board of Regents of the University of Texas System · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 10272173

    Radioactive bone cement

    The Regents of the University of California · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 10272158

    Compounds for treating biofilm infection

    The Board of Regents of the University of Texas System · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 10273307

    Humanized anti-CD134 (OX40) antibodies and uses thereof

    Biocerox Products B.V. · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 10272132

    Peptide and peptidomimetic inhibitors

    RA PHARMACEUTICALS, INC. · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 10272137

    Compositions and methods relating to myomaker-induced muscle cell fusion

    The Board of Regents of the University of Texas System · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 10272093

    Use of H3K9me3 modulation for enhancing cognitive function

    The Regents of the University of California · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 10272084

    Histone deacetylase 6 selective inhibitors for the treatment of cisplatin-induced peripheral neuropathy

    The Board of Regents of the University of Texas System · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 10272075

    Method and composition for treating an alpha adrenoceptor-mediated condition

    VANDA PHARMACEUTICALS INC. · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 10272074

    Inhibitors of glucocorticoid receptor translocation

    SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 10272076

    Methods for the administration of iloperidone

    VANDA PHARMACEUTICALS INC. · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 10272055

    Therapeutic compounds and methods

    The Regents of the University of California · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 10272051

    Method to treat atopic dermatitis

    AXIM BIOTECHNOLOGIES. INC. · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 10272037

    Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract

    The Regents of the University of California · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 10272034

    Auris formulations for treating otic diseases and conditions

    The Regents of the University of California · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 10272039

    Topical sodium nitrite formulation

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 25 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 10280158

    Immune adjustment compound, use thereof and pharmaceutical composition comprising same

    SuZhou Connect Biopharmaceuticals, Inc. · Granted Tue May 07 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 02 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 10279038

    Agonist antibodies that bind human CD137 and uses thereof

    Compass Therapeutics LLC · Granted Tue May 07 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 02 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 10280160

    Phthalazinone compounds and methods for the treatment of cystic fibrosis

    Flatley Discovery Lab, LLC · Granted Tue May 07 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 02 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 10280422

    MiR-92 inhibitors and uses thereof

    MIRAGEN THERAPEUTICS, INC. · Granted Tue May 07 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 02 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 10278372

    Genetically modified cells, tissues, and organs for treating disease

    Regents of the University of Minnesota · Granted Tue May 07 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 02 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 10278986

    Antibody-siRNA conjugates and uses therefor

    The Regents of the University of Colorado, a Body Corporate · Granted Tue May 07 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 02 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 10280415

    Human cystathionine β-synthase variants and methods of production thereof

    The Regents of the University of Colorado, a Body Corporate · Granted Tue May 07 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 02 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 10280414

    Stabilized α-galactosidase and uses thereof

    Protalix Ltd. · Granted Tue May 07 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 02 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 10280423

    Compositions and methods for modulating complement factor B expression

    Ionis Pharmaceuticals, Inc. · Granted Tue May 07 2019 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 02 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2039?

1,782 published patents in our USPTO index have expiration dates falling in calendar year 2039.

Drug approvals, clinical trials, M&A, event intelligence, and company updates — weekly.

Customize topics & region
Topics
Region

No spam. Unsubscribe anytime. See our privacy policy.