Wednesday, July 8, 2026

Drug profile · INN

trimethoprim

trimethoprim (ALPRIM) is a bacterial dihydrofolate reductase inhibitor. Associated with Alphapharm Pty Ltd. Route of administration: oral. Current US regulatory status: approved.

FDA: approved TGA: approved
US status approved
Patents linked 0
Pipeline programs 7
News articles 0
Drug details — trimethoprim
US status
approved
Class
Route
ORAL
Patents
0
Programs
7
Data quality
0.89

Quick answer

trimethoprim (ALPRIM) is a bacterial dihydrofolate reductase inhibitor. Associated with Alphapharm Pty Ltd. Route of administration: oral. Current US regulatory status: approved.

Key facts

INN trimethoprim
Brand ALPRIM
Mechanism Bacterial dihydrofolate reductase inhibitor
Target Dihydrofolate reductase
Route ORAL
Formulation TABLET

Mechanism of action

Bacterial dihydrofolate reductase inhibitor

Primary target: Dihydrofolate reductase

Approval history

Authority Status Date
FDA approved
TGA approved

Pipeline programs

  1. APHP211043 Phase 3 · PARItec · acute pyelonephritis (AP) in children
  2. APHP220763 Phase 3 · PARItec · Catheter related bloodstream infections due to Staphylococcu
  3. APHP241013 Phase 3 · PARItec · Young Adults and adults with R/R B-cell acute lymphoblastic
  4. FOSFOMYCIN , SULFAMETHOXAZOLE AND TRIMETHOPRIM Phase 3 · Tour Hekla · Benign Prostate Hyperplasia
  5. VACAB-2022 Phase 3 · George Institute for · Patients with hip or knee infections
  6. APHP200020 Approved · PARItec · Pyelonephritis, Kidney Transplant recipients
  7. MEROPENEM AND VABORBACTAM for Pyogenic liver abscess Approved · PARItec · Pyogenic liver abscess

Related & competitor drugs

  1. aminosalicylate sodium Dihydrofolate reductase inhibitor
  2. methotrexate sodium Dihydrofolate reductase inhibitor
  3. pemetrexed disodium Thymidylate synthase inhibitor
  4. pemetrexed sodium Thymidylate synthase inhibitor
  5. pralatrexate Antineoplastic and immunomodulating agents (L01)
  6. pyrimethamine Dihydrofolate reductase inhibitor

Frequently asked questions

What is trimethoprim?

trimethoprim (ALPRIM) is a bacterial dihydrofolate reductase inhibitor. Associated with Alphapharm Pty Ltd. Route of administration: oral. Current US regulatory status: approved.

What is the brand name for trimethoprim?

ALPRIM is a marketed brand name for trimethoprim. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of trimethoprim?

trimethoprim has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.