Wednesday, July 8, 2026

Drug profile · INN

pemetrexed disodium

pemetrexed disodium (PEMETREXED DISODIUM) is a thymidylate synthase inhibitor. Associated with Amneal Pharma Europe Ltd. Route of administration: intravenous. Current US regulatory status: approved.

FDA: approved
US status approved
Patents linked 1
Pipeline programs 27
News articles 0
Drug details — pemetrexed disodium
US status
approved
Class
Route
INTRAVENOUS
Patents
1
Programs
27
Data quality
0.89

Quick answer

pemetrexed disodium (PEMETREXED DISODIUM) is a thymidylate synthase inhibitor. Associated with Amneal Pharma Europe Ltd. Route of administration: intravenous. Current US regulatory status: approved.

Key facts

INN pemetrexed disodium
Brand PEMETREXED DISODIUM
Mechanism Thymidylate synthase inhibitor
Target Dihydrofolate reductase
Route INTRAVENOUS
Formulation POWDER

Mechanism of action

Thymidylate synthase inhibitor

Primary target: Dihydrofolate reductase

Approval history

Authority Status Date
FDA approved

Pipeline programs

  1. 1479-0008 Phase 3 · Boehringer Ingelheim · non-squamous non-small cell lung cancer
  2. BO40336 Phase 3 · HOFFMANN-LA ROCHE · Completely resected, Stage Ib (tumors ≥ 4 cm) to Stage IIIa,
  3. BO40729 Phase 3 · HOFFMANN-LA ROCHE · Advanced Malignancies
  4. CA209-9LA Phase 3 · Bristol-Myers Squibb Australia · Stage IV Non-Small Cell Lung Cancer (NSCLC)
  5. CA2241093 Phase 3 · Bristol-Myers Squibb Australia · Non-squamous (NSQ), Stage IV or Recurrent Non-small Cell Lun
  6. CT-P51 3.1 Phase 3 · Celltrion Healthcare Australia · Previously Untreated Metastatic Non-Squamous Non-Small Cell
  7. D5087C00001 Phase 3 · AstraZeneca · Non-Small Cell Lung Cancer
  8. D9106C00001 Phase 3 · AstraZeneca · Patients with resectable Non-small Cell Lung Cancer (Stage I

Related & competitor drugs

  1. aminosalicylate sodium Dihydrofolate reductase inhibitor
  2. methotrexate sodium Dihydrofolate reductase inhibitor
  3. pemetrexed sodium Thymidylate synthase inhibitor
  4. pralatrexate Antineoplastic and immunomodulating agents (L01)
  5. pyrimethamine Dihydrofolate reductase inhibitor
  6. trimethoprim Bacterial dihydrofolate reductase inhibitor
  1. US 8952153

    One pot process for preparing pemetrexed disodium

    Expires Mon Feb 05 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is pemetrexed disodium?

pemetrexed disodium (PEMETREXED DISODIUM) is a thymidylate synthase inhibitor. Associated with Amneal Pharma Europe Ltd. Route of administration: intravenous. Current US regulatory status: approved.

What is the brand name for pemetrexed disodium?

PEMETREXED DISODIUM is a marketed brand name for pemetrexed disodium. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of pemetrexed disodium?

pemetrexed disodium has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.