Wednesday, July 8, 2026

Drug profile · INN

trifluridine

trifluridine (LONSURF) is a dna inhibitor. Route of administration: ophthalmic. Current US regulatory status: approved.

FDA: approved EMA: approved Antineoplastic and immunomodulating agents (L01) L01BC59
US status approved
Patents linked 0
Pipeline programs 15
News articles 0
Drug details — trifluridine
US status
approved
Class
Antineoplastic and immunomodulating agents (L01)
Route
OPHTHALMIC
Patents
0
Programs
15
Data quality
0.84

Quick answer

trifluridine (LONSURF) is a dna inhibitor. Route of administration: ophthalmic. Current US regulatory status: approved.

Key facts

INN trifluridine
Brand LONSURF
Mechanism DNA inhibitor
Target DNA
Therapeutic class Antineoplastic and immunomodulating agents (L01)
Route OPHTHALMIC
Formulation SOLUTION/DROPS
ATC code L01BC59

Mechanism of action

DNA inhibitor

Primary target: DNA

Approval history

Authority Status Date
FDA approved
EMA approved

Pipeline programs

  1. 20190172 Phase 3 · Amgen · Colorectal Cancer (CRC)
  2. CA224-123 Phase 3 · Bristol-Myers Squibb Australia · Metastatic Colorectal Cancer
  3. CL3-95005-006 Phase 3 · George Institute for · Metastatic colorectal cancer
  4. D9802C00001 Phase 3 · AstraZeneca · Gastric cancer, Advanced/Metastatic Gastric cancer, Gastroes
  5. ENGIC 06 FRUQUITAS Phase 3 · CERo Therapeutics · metastatic oeso-gastric adenocarcinoma
  6. M24-064 Phase 3 · AbbVie Deutschland GmbH · Metastatic Colorectal Cancer
  7. MK-2870-015 Phase 3 · MSD Merck Sharp · advanced or metastatic gastric adenocarcinoma, gastroesophag
  8. MK-4280A-007 Phase 3 · MSD Merck Sharp · Colorectal Cancer

Related & competitor drugs

  1. abiraterone acetate Antineoplastic and immunomodulating agents (L02)
  2. acyclovir Human herpesvirus 1 DNA polymerase inhibitor
  3. acyclovir sodium Human herpesvirus 1 DNA polymerase inhibitor
  4. anagrelide Antineoplastic and immunomodulating agents (L01)
  5. apremilast Antineoplastic and immunomodulating agents (L04)
  6. arsenic trioxide Antineoplastic and immunomodulating agents (L01)

Frequently asked questions

What is trifluridine?

trifluridine (LONSURF) is a dna inhibitor. Route of administration: ophthalmic. Current US regulatory status: approved.

What is the brand name for trifluridine?

LONSURF is a marketed brand name for trifluridine. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of trifluridine?

trifluridine has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.