Wednesday, July 8, 2026

Drug profile · INN

telotristat etiprate

telotristat etiprate (XERMELO) is a tryptophan 5-hydroxylase inhibitor. Route of administration: oral. Current US regulatory status: approved.

FDA: approved
US status approved
Patents linked 5
Pipeline programs 6
News articles 0
Drug details — telotristat etiprate
US status
approved
Class
Route
ORAL
Patents
5
Programs
6
Data quality
0.84

Quick answer

telotristat etiprate (XERMELO) is a tryptophan 5-hydroxylase inhibitor. Route of administration: oral. Current US regulatory status: approved.

Key facts

INN telotristat etiprate
Brand XERMELO
Mechanism Tryptophan 5-hydroxylase inhibitor
Target Tryptophan 5-hydroxylase
Route ORAL
Formulation TABLET

Mechanism of action

Tryptophan 5-hydroxylase inhibitor

Primary target: Tryptophan 5-hydroxylase

Approval history

Authority Status Date
FDA approved

Pipeline programs

  1. Telotristat etiprate Phase 3 · LEXICON PHARMACEUTICALS · Carcinoid Syndrome
  2. Telotristat Etiprate Phase 2 · LEXICON PHARMACEUTICALS · Ulcerative Colitis
  3. Telotristat Ethyl Phase 1 · LEXICON PHARMACEUTICALS · Hepatic Impairment
  4. Telotristat etiprate Phase 1 · LEXICON PHARMACEUTICALS · Drug Interactions
  5. Telotristat etiprate Phase 1 · LEXICON PHARMACEUTICALS · Healthy
  6. Telotristat etiprate Phase 1 · LEXICON PHARMACEUTICALS · QT Interval

Related & competitor drugs

  1. telotristat ethyl Alimentary tract and metabolism (A16)

Related patents

  1. US 8653094

    Solid forms of (S)-ethyl 2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)-pyrimidin-4-yl)phenyl)propanoate and methods of their use

    Expires Mon Feb 13 2034 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 8193204

    Solid forms of (S)-ethyl 2-amino-3-(4-(2-amino-6-((R)-1- (4-chloro-2-(3-methyl-1H-pyrazol-1-YL)phenyl)2,2,2-trifluoroethoxy)-pyrimidin-4-YL)phenyl)propanoate and methods of their use

    Expires Mon May 31 2032 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 7968559

    Methods of using 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds

    Expires Mon Jun 23 2031 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 7709493

    4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use

    Expires Mon Apr 29 2030 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 7553840

    4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use

    Expires Mon Jun 25 2029 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is telotristat etiprate?

telotristat etiprate (XERMELO) is a tryptophan 5-hydroxylase inhibitor. Route of administration: oral. Current US regulatory status: approved.

What is the brand name for telotristat etiprate?

XERMELO is a marketed brand name for telotristat etiprate. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of telotristat etiprate?

telotristat etiprate has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.