Saturday, July 11, 2026

Drug profile · INN

telotristat ethyl

telotristat ethyl (XERMELO) is a tryptophan 5-hydroxylase inhibitor.

EMA: approved Alimentary tract and metabolism (A16) A16A
Patents linked 0
Pipeline programs 1
News articles 0
Drug details — telotristat ethyl
Class
Alimentary tract and metabolism (A16)
Route
Patents
0
Programs
1
Data quality
0.83

Quick answer

telotristat ethyl (XERMELO) is a tryptophan 5-hydroxylase inhibitor.

Key facts

INN telotristat ethyl
Brand XERMELO
Mechanism Tryptophan 5-hydroxylase inhibitor
Target Tryptophan 5-hydroxylase
Therapeutic class Alimentary tract and metabolism (A16)
ATC code A16A

Mechanism of action

Tryptophan 5-hydroxylase inhibitor

Primary target: Tryptophan 5-hydroxylase

Approval history

Authority Status Date
EMA approved

Pipeline programs

  1. Telotristat Ethyl Phase 1 · LEXICON PHARMACEUTICALS · Hepatic Impairment

Related & competitor drugs

  1. agalsidase alfa Alimentary tract and metabolism (A16)
  2. alogliptin Alimentary tract and metabolism (A10)
  3. alogliptin benzoate Alimentary tract and metabolism (A10)
  4. aprepitant Alimentary tract and metabolism (A04)
  5. budesonide Alimentary tract and metabolism (A07)
  6. canagliflozin Alimentary tract and metabolism (A10)

Frequently asked questions

What is telotristat ethyl?

telotristat ethyl (XERMELO) is a tryptophan 5-hydroxylase inhibitor.

What is the brand name for telotristat ethyl?

XERMELO is a marketed brand name for telotristat ethyl. Check FDA Drugs@FDA for the current US label holder and prescribing information.