Wednesday, July 8, 2026

Drug profile · INN

sotagliflozin

sotagliflozin (ZYNQUISTA) is a sodium/glucose cotransporter 2 inhibitor. Associated with LEXICON PHARMACEUTICALS, INC.. Route of administration: oral. Current US regulatory status: approved.

FDA: approved EMA: withdrawn Alimentary tract and metabolism (A10) A10
US status approved
Patents linked 20
Pipeline programs 16
News articles 0
Drug details — sotagliflozin
US status
approved
Class
Alimentary tract and metabolism (A10)
Route
ORAL
Patents
20
Programs
16
Data quality
0.89

Quick answer

sotagliflozin (ZYNQUISTA) is a sodium/glucose cotransporter 2 inhibitor. Associated with LEXICON PHARMACEUTICALS, INC.. Route of administration: oral. Current US regulatory status: approved.

Key facts

INN sotagliflozin
Brand ZYNQUISTA
Mechanism Sodium/glucose cotransporter 2 inhibitor
Target Sodium/glucose cotransporter 1
Therapeutic class Alimentary tract and metabolism (A10)
Route ORAL
Formulation TABLET
ATC code A10

Mechanism of action

Sodium/glucose cotransporter 2 inhibitor

Primary target: Sodium/glucose cotransporter 1

Approval history

Authority Status Date
FDA approved
EMA withdrawn

Pipeline programs

  1. PLACEBO SOTAGLIFLOZIN, SOTAGLIFLOZIN Phase 3 · LEXICON PHARMACEUTICALS · Obstructive Cardiomyopathy, Hypertrophic, Non-obstructive Hy
  2. Sotagliflozin Phase 3 · LEXICON PHARMACEUTICALS · Type 1 Diabetes Mellitus
  3. Sotagliflozin Phase 3 · LEXICON PHARMACEUTICALS · Type 2 Diabetes Mellitus
  4. Sotagliflozin Phase 3 · LEXICON PHARMACEUTICALS · Type 1 Diabetes Mellitus (T1DM)
  5. Sotagliflozin Phase 3 · LEXICON PHARMACEUTICALS · Obstructive Cardiomyopathy, Hypertrophic
  6. Sotagliflozin Phase 3 · LEXICON PHARMACEUTICALS · Heart Failure
  7. Sotagliflozin Phase 3 · LEXICON PHARMACEUTICALS · Diabetic Nephropathies
  8. Sotagliflozin (SAR439954) Phase 3 · LEXICON PHARMACEUTICALS · Type 2 Diabetes Mellitus

Related & competitor drugs

  1. agalsidase alfa Alimentary tract and metabolism (A16)
  2. alogliptin Alimentary tract and metabolism (A10)
  3. alogliptin benzoate Alimentary tract and metabolism (A10)
  4. aprepitant Alimentary tract and metabolism (A04)
  5. budesonide Alimentary tract and metabolism (A07)
  6. canagliflozin Alimentary tract and metabolism (A10)
  1. US 11730723

    Compounds and methods for treating viral infections

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    granted
  2. US 9067962

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  3. US 8772483

    Solid forms of (S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid

    Expires Mon Jul 03 2034 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 8772291

    Multicyclic compounds and methods of their use

    Expires Mon Jul 03 2034 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 8658682

    (E)-1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone dihydrate and methods of its use

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    granted
  6. US 8497271

    Modulators of G protein-coupled receptor 88

    Expires Mon Jul 25 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 8476413

    Sulfanyl-tetrahydropyran-based compounds and methods of their use

    Expires Mon Jun 27 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 8426414

    Modulators of G protein-coupled receptor 88

    Expires Mon Apr 18 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 8410121

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    granted
  10. US 8404732

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    granted
  11. US 8304577

    Modulators of G protein-coupled receptor 88

    Expires Mon Nov 01 2032 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 8227661

    Methods of identifying agents that ameliorate or modulate effects of PRO1328 gene disruptions

    Expires Mon Jul 19 2032 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 8217156

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    Expires Mon Jul 05 2032 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 8153804

    Aryl pyridines and methods of their use

    Expires Mon Apr 05 2032 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 8093267

    Methods of treating rheumatoid arthritis

    Expires Mon Jan 05 2032 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 7998994

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    Expires Mon Aug 11 2031 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 7897763

    Process for the preparation of substituted phenylalanines

    Expires Mon Feb 24 2031 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 7855291

    Process for the preparation of substituted phenylalanines

    Expires Mon Dec 16 2030 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 7825142

    Heterocyclic compounds, compositions comprising them and methods of their use

    Expires Mon Oct 28 2030 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 7825150

    Compositions and methods for treating immunological and inflammatory diseases and disorders

    Expires Mon Oct 28 2030 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is sotagliflozin?

sotagliflozin (ZYNQUISTA) is a sodium/glucose cotransporter 2 inhibitor. Associated with LEXICON PHARMACEUTICALS, INC.. Route of administration: oral. Current US regulatory status: approved.

What is the brand name for sotagliflozin?

ZYNQUISTA is a marketed brand name for sotagliflozin. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of sotagliflozin?

sotagliflozin has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.