Friday, July 10, 2026
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Drug profile · INN

setmelanotide

IMCIVREE

setmelanotide (IMCIVREE) is a melanocortin receptor 4 agonist. Associated with Rhythm Pharmaceuticals Netherlands B.V..

EMA: approved Alimentary tract and metabolism (A08) A08AA
Patents linked 10
Pipeline programs 17
News articles 1
Drug details — setmelanotide
Class
Alimentary tract and metabolism (A08)
Route
—
Patents
10
Programs
17
Data quality
0.89
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Quick answer

setmelanotide (IMCIVREE) is a melanocortin receptor 4 agonist. Associated with Rhythm Pharmaceuticals Netherlands B.V..

Key facts

INN setmelanotide
Brand IMCIVREE
Mechanism Melanocortin receptor 4 agonist
Target Melanocortin receptor 4
Therapeutic class Alimentary tract and metabolism (A08)
ATC code A08AA
Originator Rhythm Pharmaceuticals Netherlands B.V.

Mechanism of action

Melanocortin receptor 4 agonist

Primary target: Melanocortin receptor 4

Approval history

Authority Status Date
EMA approved —

Recent coverage

View all news
Rhythm Pharmaceuticals' IMCIVREE Receives European Commission Approval for Acquired Hypothalamic Obesity
High impact NewsRare neuroendocrine diseases / ObesityMay 2, 2026

Rhythm Pharmaceuticals' IMCIVREE Receives European Commission Approval for Acquired Hypothalamic Obesity

Rare neuroendocrine diseases / Obesity · 3 min

IMCIVREE becomes first therapy approved in both US and Europe for acquired hypothalamic obesity, targeting adults and children 4+ with hypothalamic injury.

Dr. Emily Carter

Pipeline programs

Search pipeline Sponsor programs
  1. RM-493-035 Phase 3 · Anaxis Pharma · Improper function of certain messenger materials in the body
  2. Setmelanotide Phase 3 · Rhythm Pharmaceuticals Netherlands · Obesity
  3. Setmelanotide Phase 3 · Rhythm Pharmaceuticals Netherlands · Hypothalamic Obesity
  4. Setmelanotide Phase 3 · Rhythm Pharmaceuticals Netherlands · Obesity Associated With Defects in Leptin-melanocortin Pathw
  5. Setmelanotide Phase 3 · Rhythm Pharmaceuticals Netherlands · Leptin Receptor Deficiency Obesity
  6. Setmelanotide Phase 3 · Rhythm Pharmaceuticals Netherlands · Bardet Biedl Syndrome (BBS)
  7. Setmelanotide Phase 3 · Rhythm Pharmaceuticals Netherlands · Bardet-Biedl Syndrome
  8. Setmelanotide Phase 3 · Rhythm Pharmaceuticals Netherlands · Pro-opiomelanocortin (POMC) Deficiency Obesity

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Related patents

Browse patents Rhythm Pharmaceuticals Netherlands B.V. patent hub

  1. US 12285460

    Pharmaceutical compositions

    Expires Mon Apr 24 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 12263202

    Method of treating melanocortin-4 receptor pathway-associated disorders

    Expires Mon Mar 27 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 12077612

    Peptide compositions

    Expires Mon Aug 29 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 11702448

    Method of treating melanocortin-4 receptor-associated disorders in heterozygous carriers

    Expires Mon Jul 13 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 10960046

    Method of treating melanocortin-4 receptor pathway-associated disorders

    Expires Mon Mar 25 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 10954268

    Method of treating melanocortin-4 receptor-associated disorders in heterozygous carriers

    Expires Mon Mar 18 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 10858399

    Peptide compositions

    Expires Mon Dec 03 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 10196425

    Peptide compositions

    Expires Mon Jan 31 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 10167312

    Method of treating melanocortin-4 receptor-associated disorders in heterozygous carriers

    Expires Mon Dec 27 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 9845339

    Method of treating melanocortin-4 receptor-associated disorders in heterozygous carriers

    Expires Mon Dec 14 2037 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is setmelanotide?

setmelanotide (IMCIVREE) is a melanocortin receptor 4 agonist. Associated with Rhythm Pharmaceuticals Netherlands B.V..

What is the brand name for setmelanotide?

IMCIVREE is a marketed brand name for setmelanotide. Check FDA Drugs@FDA for the current US label holder and prescribing information.

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