Wednesday, July 8, 2026

Drug profile · INN

nitric oxide

nitric oxide (INOMAX) is a soluble guanylate cyclase activator. Route of administration: inhalation. Current US regulatory status: approved.

FDA: approved EMA: approved Respiratory system (R07) R07AX
US status approved
Patents linked 20
Pipeline programs 2
News articles 0
Drug details — nitric oxide
US status
approved
Class
Respiratory system (R07)
Route
INHALATION
Patents
20
Programs
2
Data quality
0.84

Quick answer

nitric oxide (INOMAX) is a soluble guanylate cyclase activator. Route of administration: inhalation. Current US regulatory status: approved.

Key facts

INN nitric oxide
Brand INOMAX
Mechanism Soluble guanylate cyclase activator
Target Soluble guanylate cyclase
Therapeutic class Respiratory system (R07)
Route INHALATION
Formulation GAS
ATC code R07AX

Mechanism of action

Soluble guanylate cyclase activator

Primary target: Soluble guanylate cyclase

Approval history

Authority Status Date
FDA approved
EMA approved

Pipeline programs

  1. Nitric Oxide Phase 2 · Chinese Academy of · Pressure Ulcer
  2. nitric oxide gel Phase 2 · Hospital Authority · Neuropathic Pain

Related & competitor drugs

  1. desloratadine Respiratory system (R01)
  2. deutivacaftor / tezacaftor / vanzacaftor Respiratory system (R07)
  3. isosorbide dinitrate Soluble guanylate cyclase activator
  4. isosorbide mononitrate Soluble guanylate cyclase activator
  5. ivacaftor Respiratory system (R07)
  6. lumacaftor Respiratory system (R07)

Related patents

  1. US 12286405

    Scalable synthesis of dual-target inhibitor of cannabinoid-1 receptor and inducible nitric oxide synthase

    Expires Mon Apr 24 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 12251449

    Synthetic multidomain peptide biomaterials that inhibit inducible nitric oxide synthase

    Expires Mon Mar 13 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 12213973

    Bacterial nitric oxide synthase inhibitors

    Expires Mon Jan 30 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 12083113

    Use of neuronal nitric oxide synthase inhibitors for immunotherapy in melanoma patients

    Expires Mon Sep 05 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 11998513

    Two-part nitric oxide generating topical compositions

    Expires Mon May 30 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 11439632

    Use of neuronal nitric oxide synthase inhibitors for immunotherapy in melanoma patients

    Expires Mon Sep 08 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 11439609

    Nitric oxide releasing PLGA microspheres for biomedical applications

    Expires Mon Sep 08 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 11413420

    Nitric oxide delivery devices

    Expires Mon Aug 11 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 11241406

    Compositions and methods for acutley raising nitric oxide levels

    Expires Mon Feb 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 11103622

    Thromboresistant/bactericidal s-nitroso-n-acetylpenicillamine (SNAP)-doped nitric oxide release polymers with enhanced stability

    Expires Mon Aug 26 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 10759791

    Mammalian and bacterial nitric oxide synthase inhibitors

    Expires Mon Aug 27 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 10543337

    Nitric oxide delivery devices

    Expires Mon Jan 23 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 10471109

    Compositions and methods for promoting nitric oxide production through an oral delivery system

    Expires Mon Nov 07 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 10342822

    Method of producing physiological and therapeutic levels of nitric oxide through an oral delivery system

    Expires Mon Jul 04 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 9951014

    Mammalian and bacterial nitric oxide synthase inhibitors

    Expires Mon Apr 19 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 9878996

    2-imidazolyl-pyrimidine scaffolds as potent and selective inhibitors of neuronal nitric oxide synthase

    Expires Mon Jan 25 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 9872953

    Nitric oxide delivery devices

    Expires Mon Jan 18 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 9821006

    Method of producing physiological and therapeutic levels of nitric oxide through an oral delivery system

    Expires Mon Nov 16 2037 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 9763974

    Galacto-rhamnogalacturonate compositions for the treatment of diseases associated with elevated inducible nitric oxide synthase

    Expires Mon Sep 14 2037 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 9765055

    Intramolecular hydrogen-bonded nitric oxide synthase inhibitors

    Expires Mon Sep 14 2037 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is nitric oxide?

nitric oxide (INOMAX) is a soluble guanylate cyclase activator. Route of administration: inhalation. Current US regulatory status: approved.

What is the brand name for nitric oxide?

INOMAX is a marketed brand name for nitric oxide. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of nitric oxide?

nitric oxide has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.