Friday, July 10, 2026

Drug profile · INN

esketamine

esketamine (SPRAVATO) is a glutamate [nmda] receptor negative allosteric modulator. Associated with Janssen-Cilag Pty Ltd.

EMA: approved TGA: approved NMPA: clinical trials Nervous system (N06) N06AX27
Patents linked 0
Pipeline programs 23
News articles 1
Drug details — esketamine

Quick answer

esketamine (SPRAVATO) is a glutamate [nmda] receptor negative allosteric modulator. Associated with Janssen-Cilag Pty Ltd.

Key facts

INN esketamine
Brand SPRAVATO
Mechanism Glutamate [NMDA] receptor negative allosteric modulator
Target Glutamate [NMDA] receptor
Therapeutic class Nervous system (N06)
ATC code N06AX27

Mechanism of action

Glutamate [NMDA] receptor negative allosteric modulator

Primary target: Glutamate [NMDA] receptor

Approval history

Authority Status Date
EMA approved
TGA approved
NMPA clinical trials

Recent coverage

Pipeline programs

  1. 54135419SUI3003 Phase 3 · Janssen-Cilag International N.V · Major Depressive Disorder
  2. Esketamine Phase 3 · Janssen Cilag International · Depressive Disorder, Major
  3. INTENSIFY MDD Phase 3 · Disc Medicine · Major depressive disorder
  4. Determine the ED50 and ED95 of esketamine Phase 2 · First People's Hospital · Intrauterine Polyp
  5. Intravenous esketamine using Dixon's up-and-down sequential method Phase 2 · First People's Hospital · Hepatic Neoplasm
  6. Esketamine injection group (0.25 mg/kg) Phase 1 · First People's Hospital · Esketamine
  7. Dexmedetomidine-esketamine combination Approved · First People's Hospital · Obstructive Sleep Apnea
  8. Esketamine Approved · First People's Hospital · Postpartum Depression

Related & competitor drugs

  1. amantadine hydrochloride Glutamate [NMDA] receptor antagonist
  2. aripiprazole Nervous system (N05)
  3. brexpiprazole Nervous system (N05)
  4. brivaracetam Nervous system (N03)
  5. bupivacaine Nervous system (N01)
  6. buprenorphine Nervous system (N07)

Frequently asked questions

What is esketamine?

esketamine (SPRAVATO) is a glutamate [nmda] receptor negative allosteric modulator. Associated with Janssen-Cilag Pty Ltd.

What is the brand name for esketamine?

SPRAVATO is a marketed brand name for esketamine. Check FDA Drugs@FDA for the current US label holder and prescribing information.