Friday, July 10, 2026

Drug profile · INN

defibrotide

defibrotide (DEFITELIO) is a adenosine a1 receptor agonist.

EMA: approved Blood and blood forming organs (B01) B01AX01
Patents linked 1
Pipeline programs 8
News articles 0
Drug details — defibrotide
Class
Blood and blood forming organs (B01)
Route
Patents
1
Programs
8
Data quality
0.83

Quick answer

defibrotide (DEFITELIO) is a adenosine a1 receptor agonist.

Key facts

INN defibrotide
Brand DEFITELIO
Mechanism Adenosine A1 receptor agonist
Target Adenosine receptor A1
Therapeutic class Blood and blood forming organs (B01)
ATC code B01AX01

Mechanism of action

Adenosine A1 receptor agonist

Primary target: Adenosine receptor A1

Approval history

Authority Status Date
EMA approved

Pipeline programs

  1. Defibrotide Phase 3 · Jazz Pharmaceuticals Ireland · Hepatic Veno-Occlusive Disease
  2. Defibrotide Phase 3 · Jazz Pharmaceuticals Ireland · Veno-occlusive Disease
  3. Defibrotide Phase 3 · Jazz Pharmaceuticals Ireland · Severe Hepatic Veno-Occlusive Disease
  4. Defibrotide Phase 2 · Jazz Pharmaceuticals Ireland · DLBCL
  5. Defibrotide Phase 2 · Jazz Pharmaceuticals Ireland · Transplant-Associated Thrombotic Microangiopathy
  6. Defibrotide Phase 2 · Jazz Pharmaceuticals Ireland · Graft-versus-host Disease
  7. Defibrotide Phase 2 · Jazz Pharmaceuticals Ireland · Covid19
  8. Defibrotide Phase 1 · Jazz Pharmaceuticals Ireland · COVID

Related & competitor drugs

  1. apixaban Blood and blood forming organs (B01)
  2. berotralstat Blood and blood forming organs (B06)
  3. bivalirudin Blood and blood forming organs (B01)
  4. c1 inhibitor (human) Blood and blood forming organs (B06)
  5. clopidogrel Blood and blood forming organs (B01)
  6. dabigatran etexilate Blood and blood forming organs (B01)

Related patents

  1. US 11571440

    Defibrotide for the prevention and treatment of cytokine release syndrome and neurotoxicity associated with immunodepletion

    Expires Mon Feb 02 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is defibrotide?

defibrotide (DEFITELIO) is a adenosine a1 receptor agonist.

What is the brand name for defibrotide?

DEFITELIO is a marketed brand name for defibrotide. Check FDA Drugs@FDA for the current US label holder and prescribing information.