Wednesday, July 8, 2026

Drug profile · INN

cyclobenzaprine hydrochloride

cyclobenzaprine hydrochloride (CYCLOBENZAPRINE HYDROCHLORIDE) is a serotonin 2c (5-ht2c) receptor antagonist. Associated with Tonix Pharmaceuticals Holding. Route of administration: oral. Current US regulatory status: approved.

FDA: approved
US status approved
Patents linked 20
Pipeline programs 4
News articles 0
Drug details — cyclobenzaprine hydrochloride
US status
approved
Class
Route
ORAL
Patents
20
Programs
4
Data quality
0.89

Quick answer

cyclobenzaprine hydrochloride (CYCLOBENZAPRINE HYDROCHLORIDE) is a serotonin 2c (5-ht2c) receptor antagonist. Associated with Tonix Pharmaceuticals Holding. Route of administration: oral. Current US regulatory status: approved.

Key facts

INN cyclobenzaprine hydrochloride
Brand CYCLOBENZAPRINE HYDROCHLORIDE
Mechanism Serotonin 2c (5-HT2c) receptor antagonist
Target 5-hydroxytryptamine receptor 2A
Route ORAL
Formulation CAPSULE, EXTENDED RELEASE

Mechanism of action

Serotonin 2c (5-HT2c) receptor antagonist

Primary target: 5-hydroxytryptamine receptor 2A

Approval history

Authority Status Date
FDA approved

Pipeline programs

  1. Cyclobenzaprine HCl Phase 3 · Takeda · Neck Pain
  2. MRI Phase 3 · United Therapeutics Europe · Prostate Neoplasm
  3. cyclobenzaprine hydrochloride Phase 3 · Teva Pharma · Chronic Migraine
  4. Cyclobenzaprine HCl Phase 2 · Tonix Pharmaceuticals Holding · Acute Stress Reaction

Related & competitor drugs

  1. pimavanserin tartrate Serotonin 2a (5-HT2a) receptor inverse agonist
  2. trazodone hydrochloride Serotonin 2a (5-HT2a) receptor antagonist
  1. US 12383733

    Iontophoresis-based patch type medicine absorption device

    Expires Mon Aug 07 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 12304901

    Selective ligands for tau aggregates

    Expires Mon May 15 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 12156864

    Analogs of cyclobenzaprine and amitryptilene

    Expires Mon Nov 28 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 11998516

    Methods and compositions for treating depression using cyclobenzaprine

    Expires Mon May 30 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 11975161

    Drug releasing coatings for balloon catheters

    Expires Mon May 02 2044 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 11839594

    Eutectic formulations of cyclobenzaprine hydrochloride and amitriptyline hydrochloride

    Expires Mon Dec 07 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 11737991

    Eutectic formulations of cyclobenzaprine hydrochloride and amitriptyline hydrochloride

    Expires Mon Aug 24 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 11566032

    Radio-protective and chemo-protective substituted thiols

    Expires Mon Jan 26 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 11376404

    Drug releasing coatings for medical devices

    Expires Mon Jun 30 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 11026898

    Eutectic formulations of cyclobenzaprine hydrochloride

    Expires Mon Jun 03 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 10994055

    Drug releasing coatings for medical devices

    Expires Mon Apr 29 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 10946027

    Tianeptine oxalate salts and polymorphs

    Expires Mon Mar 11 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 10912932

    Drug releasing coatings for balloon catheters

    Expires Mon Feb 04 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 10912931

    Drug releasing coatings for balloon catheters

    Expires Mon Feb 04 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 10864175

    Eutectic formulations of cyclobenzaprine hydrochloride and amitriptyline hydrochloride

    Expires Mon Dec 10 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 10864176

    Eutectic formulations of cyclobenzaprine hydrochloride and amitriptyline hydrochloride

    Expires Mon Dec 10 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 10835719

    Drug releasing coatings for medical devices

    Expires Mon Nov 12 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 10736859

    Eutectic formulations of cyclobenzaprine hydrochloride and amitriptyline hydrochloride

    Expires Mon Aug 06 2040 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 10485959

    Drug releasing coatings for balloon catheters

    Expires Mon Nov 21 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 10485958

    Drug releasing coatings for balloon catheters

    Expires Mon Nov 21 2039 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is cyclobenzaprine hydrochloride?

cyclobenzaprine hydrochloride (CYCLOBENZAPRINE HYDROCHLORIDE) is a serotonin 2c (5-ht2c) receptor antagonist. Associated with Tonix Pharmaceuticals Holding. Route of administration: oral. Current US regulatory status: approved.

What is the brand name for cyclobenzaprine hydrochloride?

CYCLOBENZAPRINE HYDROCHLORIDE is a marketed brand name for cyclobenzaprine hydrochloride. Check FDA Drugs@FDA for the current US label holder and prescribing information.

What is the US approval status of cyclobenzaprine hydrochloride?

cyclobenzaprine hydrochloride has approved status in the United States according to our Drugs@FDA-derived records. Verify on the official FDA label before clinical or commercial decisions.