pharma Β· Atherosclerosis Β· Non-small Cell Lung Cancer (NSCLC)
MSD Merck Sharp
Merck Sharp and Dohme
MSD Merck Sharp trial registry β 217 ClinicalTrials.gov studies with program phase, status, and indication context.
Company details
- Status
- Public
- HQ
- WERFTESTRASSE 4, Lucerne, 6005, ch
- Employees
- 61
- Programs
- 217
- Drugs
- 180
- Patents
- 0
MSD Merck Sharp clinical trials
Registry index of 217 ClinicalTrials.gov studies linked to MSD Merck Sharp programs β each row shows trial ID, program name, phase, status, and indication.
MSD Merck Sharp trial registry β 217 ClinicalTrials.gov studies with program phase, status, and indication context.
Recent trial activity
Latest clinical program signals indexed for MSD Merck Sharp.
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MS201924_0003 β Phase 1
Clinical update -
MK-3475A-F11 β Phase 2
Clinical update -
MK-3475-905 β Phase 3
Clinical update -
V940-007 β Phase 3
Clinical update -
MS200569_0065 β Phase 1
Clinical update -
MK3475-054 β Phase 3
Clinical update -
MK-8294-001 β Phase 1
Clinical update -
MK-4482-023 β Phase 3
Clinical update
Trial registry
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CTIS β -
CTIS β - 2022-501374-19-00CTIS β
MK-2140-006
Aggressive and Indolent B-cell Malignancies (mantle cell lymphoma; chronic lymphocytic leukemia; follicular lymphoma; Richterβs syndrome)
- 2022-501697-19-00CTIS β
MK-1026-011
Small Lymphocytic Lymphoma (SLL) / Untreated Chronic Lymphocytic Leukemia (CLL)
- 2022-501697-19-01CTIS β
MK-1026-011
Small Lymphocytic Lymphoma (SLL) / Untreated Chronic Lymphocytic Leukemia (CLL)
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CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β - 2022-502781-24-01CTIS β
MK-0616, Placebo to MK-0616 - Tablet
ASCVD - Atherosclerotic Cardiovascular Disease
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CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β - 2023-504865-21-00CTIS β
MK-3543-006
Essential Thrombocythemia patients who have an inadequate response to or are intolerant of hydroxyurea
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CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β - 2023-504931-42-00CTIS β
MK-1026-003
Chronic lymphocytic leukemia/Small lymphocytic lymphoma; Richters transformation; Mantle cell lymphoma, Marginal zone lymphoma; Follicular lymphoma; WaldenstrΓΆmβs macroglobulinemia
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CTIS β -
CTIS β - 2023-504959-27-00CTIS β
MK-7339-013
Participants with Limited Stage-Small Cell Lung Cancer, who have received no prior anticancer therapy for their disease.
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CTIS β -
CTIS β -
CTIS β - 2023-505177-32-00CTIS β
V940-004
Intermediate-high -risk RCC, high-risk RCC who have undergone nephrectomy, or M1 NED RCC who have undergone nephrectomy and metastasectomy.
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CTIS β -
CTIS β -
CTIS β - 2023-505423-31-00CTIS β
MK-2870-015
advanced or metastatic gastric adenocarcinoma, gastroesophageal junction adenocarcinoma, or esophageal adenocarcinoma
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CTIS β -
CTIS β -
CTIS β -
CTIS β - 2023-505712-37-00CTIS β
V940-007
The participants must have a histologically confirmed diagnosis of resectable cSCC as the primary site of malignancy (metastatic skin involvement from another primary cancer or from an unknown primary cancer is not permitted).
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CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β - 2023-506315-17-00CTIS β
MK-3475-02D
Advanced melanoma with brain metastases, PD-1 refractory or PD-1 naive
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CTIS β -
CTIS β -
CTIS β -
CTIS β - 2023-506538-56-00CTIS β
MK-3475-B99
First-line treatment of participants with extensive-stage small cell lung cancer
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CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β - 2023-506996-89-00CTIS β
MK-3543-017
Myeloproliferative Neoplasms (Essential Thrombocythemia, Polycythemia Vera and Myelofibrosis)
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CTIS β -
CTIS β - 2023-507178-41-00CTIS β
Zilovertamab vedotin
Hematologic Malignancies or Solid Tumors in Pediatric and Young Adults
- 2023-507179-23-00CTIS β
KEYTRUDA 25 mg/mL concentrate for solution for infusion
Hematologic Malignancies or Solid Tumors in Pediatric and Young Adults
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CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β - 2023-508012-35-00CTIS β
MK-2870-019
Newly diagnosed NSCLC with resectable clinical Stage II, IIIA or IIIB (with nodal involvement [N2])
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CTIS β -
CTIS β -
CTIS β - 2023-508308-40-00CTIS β
MK-3475-A86
Metastatic (stage IV) squamous or nonsquamous non-small cell lung cancer (NSCLC).
- 2023-508323-12-00CTIS β
MK-2870-020
Recurrent or metastatic cervical cancer that has progressed on or after treatment with platinum-doublet systemic chemotherapy and anti-PD-L1/anti-PD-1 therapy.
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CTIS β - 2023-508528-36-00CTIS β
xevinapant, Xevinapant Placebo
Resected squamous cell carcinoma of the head and neck
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CTIS β - 2023-508683-30-00CTIS β
V503-021
β9vHPV vaccine is indicated in females β₯ 9 years of age in the prevention of cervical, vulvar, vaginal, and anal cancer; precancerous or dysplastic lesions; and persistent infections caused by Human Papillomavirus (HPV) types 16, 18, 31, 33, 45, 52, and 58, and genital warts (condyloma acuminata) caused by HPV types 6 and 11.β
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CTIS β - 2023-508703-21-00CTIS β
MK-9999-02A
Colorectal cancer (CRC), pancreatic ductal adenocarcinoma (PDAC), biliary tract cancer (BTC)
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CTIS β - 2023-508982-34-00CTIS β
MK-7480 Multiple Ascending Dose Study in Healthy Participants
Non-alcoholic steatohepatitis
- 2023-509136-25-00CTIS β
MK3475-054
Stage III melanoma (AJCC R0) with histologically confirmed cutaneous melanoma metastatic to lymph node, classified as (AJCC, 2010): Stage IIIA with metastasis > 1 mm; any Stage IIIB or IIIC (no in-transit metastases)
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CTIS β - 2023-509234-19-00CTIS β
MK-3475-01E
Participants With Newly Diagnosed Resectable Stages II-IIIB (N2) Non-small Cell Lung Cancer (NSCLC)
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CTIS β -
CTIS β - 2023-509542-35-00CTIS β
MK-4830-001
Advanced Pancreatic cancer, Unresectable Glioblastoma and Variants, PD-1-exposed Advanced/Met HNSCC, Advanced/Met HNSCC, Advanced/Met NSCLC, Advance/Met RCC, Advanced/Met Gastric or GEJ adenocarcinoma, Ovarian Cancer. TNBC, Advanced Mesothelioma, Advanced Solid tumors(coformulation)
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CTIS β -
CTIS β -
CTIS β - 2023-510128-66-00CTIS β
MK-2870-023
Participants with treatment-naΓ―ve metastatic squamous Non-small Cell Lung Cancer (NSCLC)
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CTIS β -
CTIS β - 2024-510871-39-00CTIS β
Enpatoran Placebo, Enpatoran
Systemic lupus erythematosus (SLE) and cutaneous lupus erythematosus (CLE)
- 2024-510872-18-00CTIS β
MS200569_0003
Systemic lupus erythematosus (SLE) and cutaneous lupus erythematosus (CLE)
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CTIS β -
CTIS β - 2024-510969-42-00CTIS β
MK-3475A
Relapsed or Refractory Classical Hodgkinβs Lymphoma (rrcHL) or Relapsed or Refractory Primary Mediastinal Large B-cell Lymphoma (rrPMBCL)
- 2024-510971-39-00CTIS β
A Single-Ascending-Dose Study of MK6916 in Healthy Participants
Acute and chronic Pain
- 2024-510979-38-00CTIS β
KEYTRUDA 25 mg/mL concentrate for solution for infusion
Relapsed or refractory Classical Hodgkins Lymphoma and relapsed or refractory Primary Mediastinal Large B-cell Lymphoma
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CTIS β -
CTIS β -
CTIS β - 2024-511202-23-00CTIS β
MS201924_0002
Epithelial ovarian cancer that progressed on prior PARP inhibitor therapy
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CTIS β - 2024-511405-27-00CTIS β
A Multiple-Ascending-Dose Study of MK-1708 in Healthy Participants
Amyotrophic lateral sclerosis and Alzheimerβs disease
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CTIS β -
CTIS β - 2024-512135-80-00CTIS β
MK-7902-013
Between ages 2 and 21 and have High Grade Glioma (HGG), Rhabdomyosarcoma (RMS), Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor (pPNET), or other solid tumor types (except osteosarcoma)
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CTIS β -
CTIS β -
CTIS β - 2024-512442-41-00CTIS β
MK-1022-011
Colorectal Carcinoma, Biliary Tract Carcinoma, Hepatocellular Carcinomaβ
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CTIS β -
CTIS β -
CTIS β - 2024-513165-39-00CTIS β
MK-3475A-F84
Participants With Metastatic Non-small Cell Lung Cancer With PD-L1 TPS β₯50%
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CTIS β - 2024-513393-22-00CTIS β
Effect of Renal Impairment on Enpatoran Pharmacokinetics
Healthy volunteers and patients with renal impairment; Intended indication: autoimmune diseases; systemic lupus erythematosus (SLE) and cutaneous lupus erythematosus (CLE), as well as dermatomyositis (DM) and polymyositis (PM).
- 2024-513492-41-00CTIS β
M9466 Alone or in Combination in Advanced Solid Tumors (DDRiver 501)
Advanced solid tumors
- 2024-513533-20-00CTIS β
Placebo to MK-7240 (Tulisokibart), tulisokibart
Crohnβs Disease or Ulcerative Colitis
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CTIS β -
CTIS β -
CTIS β -
CTIS β - 2024-514376-40-00CTIS β
MK-1022-010
High Risk Early-Stage Triple Negative Breast Cancer (TNBC) or Hormone Receptor Low Positive/Human Epidermal Growth Factor Receptor 2 Negative (HR-low+/HER2-) Breast Cancer
- 2024-514500-14-00CTIS β
MK-1084-007
Participants with KRAS G12C-Mutant, Advanced or Metastatic Nonsquamous NSCLC
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CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β - 2024-515785-14-00CTIS β
A clinical study of the V540A vaccine in healthy adults (V540A-001)
Human Papilloma virus
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CTIS β - 2024-516006-32-00CTIS β
A clinical study of MK-0472 in people with solid tumors (MK-0472-001)
Malignant Neoplasm - Solid Tumors
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CTIS β -
CTIS β -
CTIS β -
CTIS β - 2024-516619-26-00CTIS β
A clinical study of MK-3508 in healthy people (MK-3508-006)
Respiratory syncytial virus infection
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CTIS β -
CTIS β - 2024-516834-36-00CTIS β
MK-2870-011
Locally recurrent unresectable or metastatic TNBC with tumors expressing PD-L1 at the cut-off of CPS <10
- 2024-516870-31-00CTIS β
MK-8294-001
Breast Cancer, Cervical squamous cell carcinoma, Endometrial Carcinoma, Esophageal squamous cell carcinoma, Head and neck squamous cell carcinoma, Bladder Cancer
- 2024-516878-30-00CTIS β
A clinical study of MK-6916 and placebo in healthy people (MK-6916-003)
Acute and chronic Pain
- 2024-516899-15-00CTIS β
A clinical study of MK-6916 in healthy people (MK-6916-002)
Acute and Chronic Pain
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CTIS β -
CTIS β - 2024-517232-22-00CTIS β
MK-1084-012
KRAS G12C-mutant, Locally Advanced Unresectable or Metastatic Colorectal Cancer
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CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β - 2024-518863-36-00CTIS β
A clinical study of the V540C vaccine in healthy adults (V540C-003)
Human Papilloma virus
- 2024-519068-42-00CTIS β
MK-0616, Placebo to MK-0616
βHeterozygous Familial Hypercholesterolemiaβ in pediatric patients
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CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β - 2024-520190-12-00CTIS β
MK-2870-032
Breast Cancer: triple negative breast cancer (TNBC) and hormone receptor (HR)-low positive/HER2 negative breast cancer
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CTIS β -
CTIS β - 2025-520467-40-00CTIS β
MK-3120
High-risk non-muscle invasive bladder cancer (NMIBC) with carcinoma in situ (CIS) with or without papillary tumors
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CTIS β -
CTIS β -
CTIS β -
CTIS β - 2025-521059-21-00CTIS β
Placebo for MK-7240, tulisokibart
Radiographic axial spondyloarthritis (as known as ankylosing spondylitis)
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CTIS β -
CTIS β - 2025-521487-36-00CTIS β
A clinical study of MK-6916 in healthy people (MK-6916-006)
Acute and chronic Pain
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CTIS β - 2025-521514-26-00CTIS β
MK-2870-036
Persistent, Recurrent, or Newly Diagnosed Metastatic Cervical Cancer With PD-L1 CPS Greater Than or Equal to 1
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CTIS β -
CTIS β - 2025-521939-36-00CTIS β
MK-3475-01J
Participants with KRAS G12C-Mutant, Advanced or Metastatic Nonsquamous NSCLC
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CTIS β -
CTIS β -
CTIS β -
CTIS β - 2025-522495-84-00CTIS β
A Clinical study of MK-4716 in people with certain solid tumors (MK-4716-001)
Cancer β Solid Tumors : 1L NSCLC and all other advanced or metastatic solid tumors with KRAS alterations (KRAS mutation or KRAS amplification)
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CTIS β -
CTIS β -
CTIS β -
CTIS β - 2025-523861-58-00CTIS β
A clinical study of MK-6050 in healthy people (MK-6050-001)
Hidradenitis suppurativa
- 2025-524160-38-00CTIS β
MK-6482-043
Renal Cell Carcinoma, hepatocellular carcinoma, nonMSI-H/dMMR colorectal cancer, pancreatic ductal adenocarcinoma, biliary tract cancer, non-MSIH/dMMR endometrial cancer, esophageal squamous cell carcinoma, Advanced Pheochromocytoma/Paraganglioma, Pancreatic Neuroendocrine Tumor, von Hippel-Lindau (VHL)Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor, Advanced Solid Tumors With HIF-2Ξ± related Genetic Alterations
- 2025-524570-41-00CTIS β
A clinical trial of MK-6916 in healthy participants (MK-6916-010)
Acute and Chronic pain
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CTIS β -
CTIS β - 2026-525625-21-00CTIS β
A clinical trial of MK-6050 in healthy participants (MK-6050-002)
Hidradenitis suppurativa
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CTIS β - 2026-525748-14-00CTIS β
A clinical trial of MK-1824 in healthy participants (MK-1824-001)
Heart failure with preserved ejection fraction