Wednesday, June 10, 2026

pharma Β· Type 2 Diabetes Mellitus Β· Irritable Bowel Syndrome Β· LXRX

LEXICON PHARMACEUTICALS

LEXICON PHARMACEUTICALS patent portfolio β€” 102 USPTO pharmaceutical patents (A61K/A61P) with grant dates, status, and loss-of-exclusivity filters.

8800 Technology Forest, The Woodlands, TX 77381, US HQ
1995 Founded
282 Employees
Public company Type
LXRX Β· NYSE Ticker
Company details
Status
Public
HQ
8800 Technology Forest, The Woodlands, TX 77381, US
Founded
1995
Employees
282
Programs
51
Drugs
27
Patents
102
Intelligence Β· Patents

LEXICON PHARMACEUTICALS patents

102 pharmaceutical patents indexed for LEXICON PHARMACEUTICALS. 4 expire within 24 months.

LEXICON PHARMACEUTICALS has 102 pharmaceutical patents in our USPTO PatentsView index (A61K/A61P). 4 expire within 24 months β€” use filters for patent-cliff planning.

Patent portfolio

Page 1 of 3
  1. US 12344596

    Solid forms of (S)-1-((2β€²,6-bis(difluoromethyl)-[2,4β€²-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine and salts thereof

    Expires Mon Jun 26 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 11730723

    Compounds and methods for treating viral infections

    Expires Mon Aug 17 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 11666575

    Pyrazolo[1,5]pyrimidine-based compounds and methods of their use to treat viral infections

    Expires Mon Jun 01 2043 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 11059907

    Antibodies that bind Notum Pectinacetylesterase

    Expires Mon Jul 08 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 10106569

    Inhibitors of sodium glucose transporter 1 for constipation

    Expires Mon Oct 18 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 9862724

    Pyrazolo[1,5-a]pyrimidine-based compounds, compositions comprising them, and methods of their use

    Expires Mon Jan 04 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 9688710

    Inhibitors of sodium glucose cotransporter 1

    Expires Mon Jun 22 2037 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 9682982

    Inhibitors of adapter associated kinase 1, compositions comprising them, and methods of their use

    Expires Mon Jun 15 2037 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 9624238

    4H-thieno[3,2-C]chromene-based inhibitors of Notum Pectinacetylesterase and methods of their use

    Expires Mon Apr 13 2037 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 9403832

    Pyrazolo[1,5-a]pyrimidine-based compounds, compositions comprising them, and methods of their use

    Expires Mon Jul 28 2036 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 9365602

    Sodium glucose co-transporter inhibitors and methods of their use

    Expires Mon Jun 09 2036 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 9200025

    Inhibitors of sodium glucose cotransporter 1

    Expires Mon Nov 26 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 9067962

    Methods of treating diabetes

    Expires Mon Jun 25 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 8969565

    Imidazo[1,2-b]pyridazine-based compounds, compositions comprising them, and methods of their use

    Expires Mon Feb 26 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 8946415

    Pyrazolo[1,5-a]pyrimidine-based compounds, compositions comprising them, and methods of their use

    Expires Mon Jan 29 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 8772482

    4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use

    Expires Mon Jul 03 2034 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 8772483

    Solid forms of (S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid

    Expires Mon Jul 03 2034 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 8772291

    Multicyclic compounds and methods of their use

    Expires Mon Jul 03 2034 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 8742075

    Monoclonal antibodies against ANGPTL3

    Expires Mon May 29 2034 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 8735408

    Solid forms of 3-(4-(aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido)phenyl dimethylcarbamate

    Expires Mon May 22 2034 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 8658682

    (E)-1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone dihydrate and methods of its use

    Expires Mon Feb 20 2034 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 8653094

    Solid forms of (S)-ethyl 2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)-pyrimidin-4-yl)phenyl)propanoate and methods of their use

    Expires Mon Feb 13 2034 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 8629156

    Tryptophan hydroxylase inhibitors

    Expires Mon Jan 09 2034 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 8591891

    Monoclonal antibodies against ANGPTL4

    Expires Mon Nov 21 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 8507672

    Substituted pyrrolo[2,3-d]pyrimidines as LIM kinase 2 inhibitors

    Expires Mon Aug 08 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 8497271

    Modulators of G protein-coupled receptor 88

    Expires Mon Jul 25 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 8476413

    Sulfanyl-tetrahydropyran-based compounds and methods of their use

    Expires Mon Jun 27 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 8450332

    LIMK2 inhibitors, compositions comprising them, and methods of their use

    Expires Mon May 23 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 8450532

    Compounds useful in the preparation of tryptophan hydroxylase inhibitors

    Expires Mon May 23 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 8440652

    MST1 kinase inhibitors and methods of their use

    Expires Mon May 09 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 8426414

    Modulators of G protein-coupled receptor 88

    Expires Mon Apr 18 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 8410121

    Methods of treating pulmonary hypertension

    Expires Mon Mar 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 8404732

    Methods of treating ulcerative colitis

    Expires Mon Mar 21 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 8304577

    Modulators of G protein-coupled receptor 88

    Expires Mon Nov 01 2032 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 8293878

    Methods and compounds useful for the preparation of sodium glucose co-transporter 2 inhibitors

    Expires Mon Oct 18 2032 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 8227661

    Methods of identifying agents that ameliorate or modulate effects of PRO1328 gene disruptions

    Expires Mon Jul 19 2032 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 8217156

    Solid forms of (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triol and methods of their use

    Expires Mon Jul 05 2032 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 8193202

    LIMK2 inhibitors, compositions comprising them, and methods of their use

    Expires Mon May 31 2032 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 8193204

    Solid forms of (S)-ethyl 2-amino-3-(4-(2-amino-6-((R)-1- (4-chloro-2-(3-methyl-1H-pyrazol-1-YL)phenyl)2,2,2-trifluoroethoxy)-pyrimidin-4-YL)phenyl)propanoate and methods of their use

    Expires Mon May 31 2032 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 8153804

    Aryl pyridines and methods of their use

    Expires Mon Apr 05 2032 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 8093245

    4-amino-1H-pyrimidin-2-one based compounds, compositions comprising them and methods of their use

    Expires Mon Jan 05 2032 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 8093246

    O-linked pyrimidin-4-amine-based compounds, compositions comprising them, and methods of their use to treat cancer

    Expires Mon Jan 05 2032 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 8093267

    Methods of treating rheumatoid arthritis

    Expires Mon Jan 05 2032 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 8093280

    Methods of preparing imidazole-based compounds

    Expires Mon Jan 05 2032 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 8092796

    Monoclonal antibodies against ANGPTL4

    Expires Mon Jan 05 2032 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 8093291

    Methods of using and compositions comprising tryptophan hydroxylase inhibitors

    Expires Mon Jan 05 2032 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 8063057

    Multicyclic amino acid derivatives and methods of their use

    Expires Mon Nov 17 2031 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 8026347

    Methods and compounds useful for the preparation of sodium glucose co-transporter 2 inhibitors

    Expires Mon Sep 22 2031 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many patents does LEXICON PHARMACEUTICALS have?

102 published patents match the current filter (all indexed). The full portfolio is indexed from USPTO PatentsView (A61K/A61P).

When do LEXICON PHARMACEUTICALS patents expire?

4 patents in the full portfolio expire within 24 months. Use the expiring filters above or open individual patent pages for grant and expiration dates.