LEXICON PHARMACEUTICALS

Latest clinical program signals indexed for LEXICON PHARMACEUTICALS.

1. PLACEBO SOTAGLIFLOZIN, SOTAGLIFLOZIN — Phase 3

   Jun 8, 2026
   Clinical update →

2. Treatment A digoxin — Phase 1

   Jun 8, 2026
   Clinical update →

3. Telotristat Ethyl — Phase 1

   Jun 8, 2026
   Clinical update →

4. Sotagliflozin (SOTA) followed by 3 drugs in a random order — Phase 1

   Jun 8, 2026
   Clinical update →

5. Sotagliflozin Low Dose — Phase 3

   Jun 8, 2026
   Clinical update →

6. Sotagliflozin — Phase 2

   Jun 8, 2026
   Clinical update →

7. LX6171 High Dose — Phase 2

   Jun 8, 2026
   Clinical update →

8. Fexofenadine — Phase 1

   Jun 8, 2026
   Clinical update →

1. 2024-513869-39-00

   PLACEBO SOTAGLIFLOZIN, SOTAGLIFLOZIN

   Phase 3 · active · small_molecule

   Obstructive Cardiomyopathy, Hypertrophic, Non-obstructive Hypertrophic Cardiomyopathy

   CTIS ↗
2. NCT00691808

   LX6171 High Dose

   Phase 2 · completed · small_molecule

   Age-Related Memory Disorders

   CT.gov ↗
3. NCT00813098

   LX1031 High Dose

   Phase 2 · completed · small_molecule

   Irritable Bowel Syndrome

   CT.gov ↗
4. NCT00847886

   LX3305

   Phase 1 · completed · small_molecule

   Rheumatoid Arthritis

   CT.gov ↗
5. NCT00853047

   Telotristat etiprate

   Phase 3 · completed · small_molecule

   Carcinoid Syndrome

   CT.gov ↗
6. NCT00903383

   LX3305 low dose

   Phase 2 · completed · small_molecule

   Rheumatoid Arthritis

   CT.gov ↗
7. NCT00962065

   LX4211 Low Dose

   Phase 2 · completed · small_molecule

   Type 2 Diabetes Mellitus

   CT.gov ↗
8. NCT01104415

   Telotristat etiprate

   Phase 3 · completed · small_molecule

   Carcinoid Syndrome

   CT.gov ↗
9. NCT01188863

   300 mg LX4211 (150 mg tablets)

   Phase 1 · completed · small_molecule

   Type 2 Diabetes Mellitus

   CT.gov ↗
10. NCT01292993

    400 mg LX4211

    Phase 1 · completed · small_molecule

    Type 2 Diabetes Mellitus

    CT.gov ↗
11. NCT01334242

    Schedule A

    Phase 1 · completed · small_molecule

    Healthy

    CT.gov ↗
12. NCT01376557

    75 mg LX4211

    Phase 2 · completed · small_molecule

    Type 2 Diabetes Mellitus

    CT.gov ↗
13. NCT01411800

    250 mg capsule

    Phase 1 · completed · small_molecule

    Irritable Bowel Syndrome

    CT.gov ↗
14. NCT01417052

    50 mg LX3305 QD

    Phase 1 · completed · small_molecule

    Rheumatoid Arthritis

    CT.gov ↗
15. NCT01441232

    LX4211

    Phase 1 · completed · small_molecule

    Type 2 Diabetes Mellitus

    CT.gov ↗
16. NCT01456052

    Telotristat Etiprate

    Phase 2 · completed · small_molecule

    Ulcerative Colitis

    CT.gov ↗
17. NCT01494233

    250 mg LX1033 tablets

    Phase 2 · completed · small_molecule

    Irritable Bowel Syndrome

    CT.gov ↗
18. NCT01528111

    LX7101 (0.125%)

    Phase 2 · completed · small_molecule

    Primary Open-angle Glaucoma

    CT.gov ↗
19. NCT01555008

    LX4211

    Phase 1 · completed · small_molecule

    Type 2 Diabetes Mellitus

    CT.gov ↗
20. NCT01677910

    Telotristat etiprate

    Phase 3 · completed · small_molecule

    Carcinoid Syndrome

    CT.gov ↗
21. NCT01742208

    Sotagliflozin

    Phase 3 · completed · small_molecule

    Type 1 Diabetes Mellitus

    CT.gov ↗
22. NCT01818232

    [14C]-LX4211

    Phase 1 · completed · small_molecule

    Healthy

    CT.gov ↗
23. NCT01913002

    LX4211 800 mg

    Phase 1 · completed · small_molecule

    Healthy

    CT.gov ↗
24. NCT01916850

    LX4211 400 mg

    Phase 1 · completed · small_molecule

    Healthy

    CT.gov ↗
25. NCT01916863

    LX4211 400 mg

    Phase 1 · completed · small_molecule

    Healthy Subjects

    CT.gov ↗
26. NCT01932528

    500 mg [14C]-LX1606

    Phase 1 · completed · small_molecule

    Carcinoid Syndrome

    CT.gov ↗
27. NCT02026063

    Telotristat etiprate

    Phase 3 · completed · small_molecule

    Carcinoid Syndrome

    CT.gov ↗
28. NCT02063659

    Telotristat etiprate

    Phase 3 · completed · small_molecule

    Carcinoid Syndrome

    CT.gov ↗
29. NCT02147808

    Telotristat etiprate

    Phase 1 · completed · small_molecule

    Drug Interactions

    CT.gov ↗
30. NCT02155205

    Telotristat etiprate

    Phase 1 · completed · small_molecule

    QT Interval

    CT.gov ↗
31. NCT02157558

    Fexofenadine

    Phase 1 · completed · small_molecule

    Drug Interactions

    CT.gov ↗
32. NCT02157584

    Telotristat etiprate

    Phase 1 · completed · small_molecule

    Healthy

    CT.gov ↗
33. NCT02195635

    Telotristat etiprate

    Phase 1 · completed · small_molecule

    Drug Interactions

    CT.gov ↗
34. NCT02300350

    Treatment A digoxin

    Phase 1 · completed · small_molecule

    Healthy

    CT.gov ↗
35. NCT02300363

    Treatment A (rosuvastatin)

    Phase 1 · completed · small_molecule

    Healthy

    CT.gov ↗
36. NCT02373046

    LX4211

    Phase 1 · completed · small_molecule

    Healthy

    CT.gov ↗
37. NCT02383940

    Sotagliflozin

    Phase 3 · completed · small_molecule

    Type 1 Diabetes Mellitus

    CT.gov ↗
38. NCT02384941

    Placebo

    Phase 3 · completed · small_molecule

    Type 1 Diabetes Mellitus

    CT.gov ↗
39. NCT02421510

    Sotagliflozin

    Phase 3 · completed · small_molecule

    Type 1 Diabetes Mellitus

    CT.gov ↗
40. NCT02459899

    Placebo

    Phase 3 · completed · small_molecule

    Type 1 Diabetes Mellitus

    CT.gov ↗
41. NCT02471274

    sotagliflozin

    Phase 1 · completed · small_molecule

    Hepatic Impairment

    CT.gov ↗
42. NCT02494609

    sotagliflozin

    Phase 1 · active · small_molecule

    Healthy

    CT.gov ↗
43. NCT02531035

    Sotagliflozin

    Phase 3 · completed · small_molecule

    Type 1 Diabetes Mellitus (T1DM)

    CT.gov ↗
44. NCT02647918

    Sotagliflozin

    Phase 1 · completed · small_molecule

    Renal Impairment

    CT.gov ↗
45. NCT02926937

    Sotagliflozin (SAR439954)

    Phase 3 · completed · small_molecule

    Type 2 Diabetes Mellitus

    CT.gov ↗
46. NCT02926950

    Sotagliflozin (SAR439954)

    Phase 3 · completed · small_molecule

    Type 2 Diabetes Mellitus

    CT.gov ↗
47. NCT03066830

    Sotagliflozin (SAR439954)

    Phase 3 · completed · small_molecule

    Type 2 Diabetes Mellitus

    CT.gov ↗
48. NCT03242018

    Placebo

    Phase 3 · completed · small_molecule

    Type 2 Diabetes Mellitus

    CT.gov ↗
49. NCT03242252

    Placebo

    Phase 3 · completed · small_molecule

    Type 2 Diabetes Mellitus

    CT.gov ↗
50. NCT03285594

    Sotagliflozin

    Phase 3 · terminated · small_molecule

    Type 2 Diabetes Mellitus

    CT.gov ↗
51. NCT03292653

    Sotagliflozin

    Phase 2 · terminated · small_molecule

    Cardiac Failure Aggravated

    CT.gov ↗
52. NCT03302845

    Omeprazole 40 MG

    Phase 1 · completed · small_molecule

    Drug-drug Interaction

    CT.gov ↗
53. NCT03315143

    Sotagliflozin

    Phase 3 · terminated · small_molecule

    Heart Failure

    CT.gov ↗
54. NCT03332771

    Sotagliflozin (SAR439954)

    Phase 3 · completed · small_molecule

    Type 2 Diabetes Mellitus

    CT.gov ↗
55. NCT03351478

    Sotagliflozin

    Phase 3 · terminated · small_molecule

    Type 2 Diabetes Mellitus

    CT.gov ↗
56. NCT03386344

    Sotagliflozin

    Phase 3 · terminated · small_molecule

    Type 2 Diabetes Mellitus

    CT.gov ↗
57. NCT03423446

    Telotristat Ethyl

    Phase 1 · completed · small_molecule

    Hepatic Impairment

    CT.gov ↗
58. NCT03521934

    Sotagliflozin

    Phase 3 · terminated · small_molecule

    Heart Failure

    CT.gov ↗
59. NCT03910387

    Gemcitabine

    Phase 2 · completed · small_molecule

    Locally Advanced Unresectable Pancreatic Adenocarcinoma

    CT.gov ↗
60. NCT04455633

    LX9211

    Phase 2 · completed · small_molecule

    Diabetic Peripheral Neuropathy

    CT.gov ↗
61. NCT04662281

    Placebo

    Phase 2 · completed · small_molecule

    Postherpetic Neuralgia

    CT.gov ↗
62. NCT05696366

    Sotagliflozin

    Phase 2 · active · small_molecule

    Type 1 Diabetes

    CT.gov ↗
63. NCT06203002

    Placebo (blinded)

    Phase 2 · completed · small_molecule

    Diabetic Peripheral Neuropathic Pain

    CT.gov ↗
64. NCT06217302

    Sotagliflozin

    Phase 3 · active · small_molecule

    Diabetic Nephropathies

    CT.gov ↗
65. NCT06435156

    Sotagliflozin

    Phase 2 · active · small_molecule

    Type 1 Diabetes

    CT.gov ↗
66. NCT06481891

    Sotagliflozin

    Phase 3 · active · small_molecule

    Obstructive Cardiomyopathy, Hypertrophic

    CT.gov ↗
67. NCT06933056

    Sotagliflozin (SOTA) followed by 3 drugs in a random order

    Phase 1 · active · small_molecule

    Platelet Function and Reactivity Tests

    CT.gov ↗
68. NCT07211802

    Sotagliflozin Low Dose

    Phase 3 · active · small_molecule

    Type 1 Diabetes (T1D)

    CT.gov ↗