pharma Β· Inflammatory Bowel Disease (IBD) Β· Melanoma Β· IRON
Disc Medicine
Disc Medicine trial registry β 309 ClinicalTrials.gov studies with program phase, status, and indication context.
Company details
- Status
- Public
- HQ
- 321 Arsenal St., Suite 101, Watertown, Massachusetts 02472-5710, US
- Employees
- 165
- Programs
- 308
- Drugs
- 442
- Patents
- 706
Disc Medicine clinical trials
Registry index of 309 ClinicalTrials.gov studies linked to Disc Medicine programs β each row shows trial ID, program name, phase, status, and indication.
Disc Medicine trial registry β 309 ClinicalTrials.gov studies with program phase, status, and indication context.
Recent trial activity
Latest clinical program signals indexed for Disc Medicine.
-
NL77785.078.21 β Approved
Clinical update -
Sodium Chloride Fresenius Kabi Italia 0.9 % S... β Approved
Clinical update -
Sodium Chloride 0.9% for Vulvar High-Grade Squamous Intrβ¦ β Approved
Clinical update -
202100617 β Phase 3
Clinical update -
17651 β Phase 1
Clinical update -
UMCG-NEOLYNC-001 β Phase 1
Clinical update -
TIL in NSCLC β Phase 1
Clinical update -
RT2019-13 β Phase 3
Clinical update
Trial registry
-
CTIS β -
CTIS β - 2023-504690-21-00CTIS β
Oxytocine and migraine
This is a study in healthy volunteers. We will study the trigeminovascular system, which is relevant in the pathophysiology of migraine.
- 2023-504880-18-00CTIS β
CRISP ITCC-053
Neuroblastoma (NBL), Rhabdomyosarcoma (RMS), Inflammatory Myofibroblastic Tumors (IMT), Other ALK/ROS1/MET-positive malignancies, Anaplastic Large Cell Lymphoma (ALCL)
-
CTIS β -
CTIS β -
CTIS β - 2023-506395-27-00CTIS β
Avastin 25 mg/ml concentrate for solution for infusion.
Barrett's esophagus, Colon carcinoma, gastrointestinal dysplasia
-
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β - 2023-506698-36-00CTIS β
Suprefact Depot 9 for low-volume metastatic castration-sensitive prostate cancer
low-volume metastatic castration-sensitive prostate cancer
- 2023-506792-94-00CTIS β
Sodium Chloride 0.9% for Vulvar High-Grade Squamous Intrβ¦
Vulvar High-Grade Squamous Intraepithelial Lesion (vHSIL)
-
CTIS β - 2023-506982-73-00CTIS β
Embrace-III Hi-Risk
high risk or poor response after chemoradiation and brachytherapy for locally advanced cervix cancer
-
CTIS β -
CTIS β -
CTIS β - 2023-507489-20-00CTIS β
Placebo of rosuvastatin (tablet) as produced...
Statin-intolerance, High cardiovascular risk (previous cardiovascular disease or familial hypercholesterolemia)
- 2023-507843-12-01CTIS β
Placebo cannabis oil. Components: cannabis gr... for Refractory Epilepsy
Refractory Epilepsy
-
CTIS β -
CTIS β -
CTIS β -
CTIS β - 2023-508389-13-00CTIS β
202100617
Combined endpoint of all-cause mortality, kidney failure, and hospitalization for heart failure in the overall study population
- 2023-508391-11-00CTIS β
Humira 40 mg solution for injection in pre-filled syringe
Inflammatory Bowel Disease (IBD)
-
CTIS β -
CTIS β - 2023-508731-31-01CTIS β
CELLULOSE for Mimic an acute stress response in humans.
Mimic an acute stress response in humans.
- 2023-509076-42-00CTIS β
KIMMTRAK 100 micrograms/0.5 mL concentrate for solution for infusion
Metastatic uveal melanoma with resectable liver metastasis and absence of extra-liver disease
-
CTIS β -
CTIS β - 2023-509156-34-02CTIS β
AMINOHIPPURIC ACID for Chronic Kidney Disease Kidney Failure
Chronic Kidney Disease Kidney Failure
- 2023-509183-17-00CTIS β
Molecular imaging with FAPI for diagnosing the CSM4 colorectal cancer subtype
Colorectal cancer, liver metastases
- 2023-509210-10-00CTIS β
NL85300.041.23
Metastatic or unresectable solid malignancies. Standard of care treatment options must not be available or not be considered feasible. Patients must have a primary tumor or metastasis that is suitable for HIFU-HT treatment.
-
CTIS β -
CTIS β -
CTIS β - 2023-509675-16-01CTIS β
HEPARIN , NADROPARIN
All patients who receive ECMO treatment during the study period in one the participating centers from which (deferred) informed consent is obtained. Patients in whom the ECMO is only used to bridge a procedure like a high risk percutaneous coronary intervention or during surgery are excluded.
- 2023-509732-25-00CTIS β
Mektovi film-coated tablets for metastatic colorectal cancer wiβ¦
metastatic colorectal cancer with a proven RAS mutation after failure of standard systemic treatment regimens including at least 5- FU/capecitabine-oxaliplatin and irinotecan based standard treatment (unless contra-indications for either oxaliplatin or irinotecan)
-
CTIS β -
CTIS β - 2023-510488-36-01CTIS β
18870
Chronic obstructive pulmonary disease (COPD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and atypical Parkinson disorder (APD), particularly multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal syndrome (CBS).
- 2024-510617-15-00CTIS β
Irinotecan HCl-trihydraat Accord /ml concentr...
Non-metastatic resectable pancreatic cancer
-
CTIS β -
CTIS β - 2024-510924-38-00CTIS β
IL-6 aGVHD Siltuximab: A phase II study to as...
Grade III/IV acute graft versus host disease of the liver of/and the gastro-intestinal tract
-
CTIS β -
CTIS β - 2024-511008-17-00CTIS β
Cymbalta hard gastro-resistant capsules for chemotherapy-induced neuropathiβ¦
chemotherapy-induced neuropathic pain
-
CTIS β - 2024-511090-30-00CTIS β
Sodium Chloride Fresenius Kabi Italia 0.9 % S...
Fibrous dysplasia/McCune-Albright syndrome
-
CTIS β - 2024-511151-18-01CTIS β
NL202100762
Patients with stage II-IV high risk diffuse large B-cell lymphoma, defined as international prognostic index > 2, Lymphoma
-
CTIS β - 2024-511252-41-00CTIS β
RT2019-13
Patients with biochemical recurrence after primary treatment of prostate cancer presenting with =<4 metastases
-
CTIS β -
CTIS β -
CTIS β -
CTIS β - 2024-511580-28-02CTIS β
METFORMIN for PASC: post-acute sequelae of SARS-CoV-2 infection
PASC: post-acute sequelae of SARS-CoV-2 infection
- 2024-511585-36-00CTIS β
PROGRAF capsule for pediatric kidney transplant recipients
pediatric kidney transplant recipients
-
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β - 2024-512318-16-00CTIS β
2024-512318-16-00
Patients with colorectal peritoneal metastases with a PCI-score of 1-20
-
CTIS β -
CTIS β - 2024-512544-27-00CTIS β
Placebo used in this trial is a foodgrade for Autosomal Dominant Polycystic Kβ¦
Autosomal Dominant Polycystic Kidney Disease
- 2024-512553-25-00CTIS β
MCA-derived MSC therapy in renal transplant recipients
Rejection transplanted kidney, BPAR
- 2024-512616-21-00CTIS β
Tiragolumab for HNSCC, metastatic deficient misβ¦
HNSCC, metastatic deficient mismatch repair (dMMR)/MSI-high (MSI-H) tumors, irresectable or metastatic melanoma, locally advanced or metastatic solid tumor
-
CTIS β -
CTIS β -
CTIS β -
CTIS β - 2024-512862-32-00CTIS β
KEYTRUDA 25 mg/mL concentrate for solution for infusion
Vulvar squamous cell carcinoma
-
CTIS β - 2024-512968-57-00CTIS β
RESTART; Autologous Transplantation of Adult...
Patients operated with curative intend for head and neck cancer with an indication for bilateral postoperative radiotherapy, with or without chemotherapy.
- 2024-512975-11-01CTIS β
Bavencio 20 mg/mL concentrate for solution for infusion
urothelial cancer, Bladder cancer, muscle invasive bladder cancer
- 2024-513007-14-00CTIS β
Improving Peptide Receptor Radionuclide Therapy with PARP inhibitors
locally advanced or metastatic, well-differentiated gastro-enteropancreatic neuroendocrine tumors.
- 2024-513041-37-00CTIS β
18-791
Brain injury in neonates with critical congenital heart disease requiring cardiac surgery with cardiopulmonary bypass.
-
CTIS β -
CTIS β - 2024-513124-41-00CTIS β
NL79088.041.21
Primary antibody deficiency: - Unclassified antibody deficiency (unPAD) - IgA deficiency - Specific polysaccharide antibody deficiency (SPAD) - IgG subclass deficiency (IgSD) - Common variable immunodeficiency (CVID) - Agammaglobulinemia (X-linked or otherwise)
- 2024-513186-39-01CTIS β
YERVOY for castration-resistant prostate cβ¦
castration-resistant prostate cancer
-
CTIS β - 2024-513310-36-01CTIS β
Radio-Flu 0 for Transthyretin amyloid cardiomyopathy
Transthyretin amyloid cardiomyopathy
-
CTIS β -
CTIS β - 2024-513363-15-01CTIS β
LACTOSE MONOHYDRATE for (Chronic) Peripheral (occlusive) arterial disease (PAD)
(Chronic) Peripheral (occlusive) arterial disease (PAD)
-
CTIS β - 2024-513390-50-00CTIS β
STRATIFY; Near-infrared fluorescence molecula...
Crohn's disease, Spondyloarthritis, Rheumatoid arthritis, Ulcerative colitis
-
CTIS β -
CTIS β - 2024-513486-39-00CTIS β
Placebo Colchicine tablets for Aortic Valve Calcification, Infβ¦
Aortic Valve Calcification, Inflammation, Calcification, Aortic Valve Disease, Cardiovascular Diseases, Aortic Valve Stenosis
- 2024-513516-99-00CTIS β
Durability of protection after single immunis... for Falciparum malaria
Falciparum malaria
-
CTIS β - 2024-513622-35-00CTIS β
1-(3-(fluoro-18F)benzyl)guanidine ([18F]mFBG)
Pheochromocytoma β endocrine adrenal tumor
-
CTIS β -
CTIS β -
CTIS β - 2024-513883-24-00CTIS β
LIOTHYRONINE for Hypothyroidism Triiodothyronineβ¦
Hypothyroidism Triiodothyronine Quality of Life Persistant complaints
-
CTIS β - 2024-513924-41-01CTIS β
METHADONE for Opioid use disorder (DSM-5); chβ¦
Opioid use disorder (DSM-5); chronic non-cancer pain (ICD-11).
-
CTIS β -
CTIS β -
CTIS β -
CTIS β - 2024-514054-70-00CTIS β
Dendritic cell therapy combined with surgery in mesothelioma (ENSURE)
Adult patients diagnosed with resectable epithelioid MPM, following first-line chemotherapy.
-
CTIS β - 2024-514073-22-01CTIS β
PLASMA for Coagulation in pediatric cardiaβ¦
Coagulation in pediatric cardiac surgery
-
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β - 2024-514488-24-02CTIS β
Cinryze powder and solvent for solution for i... for Traumatic Brain Injury
Traumatic Brain Injury
-
CTIS β -
CTIS β -
CTIS β - 2024-514598-23-00CTIS β
Safety and efficacy of IMM-101 combined with...
Limited metastatic pancreatic cancer
- 2024-514612-27-01CTIS β
Instant MSC Product accompanying Autologous Chondron Transplantation (IMPACT)
Symptomatic articular cartilage lesion of the knee (femoral condyles or trochlea)
-
CTIS β - 2024-514620-17-00CTIS β
CAPECITABINE , OXALIPLATIN
Patients with early-stage rectal cancer (defined as early rectal cancer cT1-3abN0M0 or early-intermediate rectal cancer cT1-3abN1(β€3 nodes β€8mm)M0
- 2024-514693-47-00CTIS β
TAGRISSO 80 mg film-coated tablets
EGFR mutated locally advanced or metastatic non-small cell lung cancer
- 2024-514693-47-01CTIS β
TAGRISSO 80 mg film-coated tablets
EGFR mutated locally advanced or metastatic non-small cell lung cancer
-
CTIS β -
CTIS β -
CTIS β - 2024-514919-10-00CTIS β
Cisplatin Accord Healthcare 1 mg/ml concentraat voor oplossing voor infusie
Locally advanced head and neck squamous cell carcinoma
-
CTIS β -
CTIS β -
CTIS β - 2024-515312-50-00CTIS β
Tetanusvaccin, suspensie voor injectie 40 IE
Systemic sclerosis, Systemic lupus erythematosus, Rheumatoid arthritis
- 2024-515357-16-00CTIS β
Proleukin 18 x 106 IE Poeder voor oplossing voor injectie of infusie
MDS with excess blasts, MDS/AML or AML patients
- 2024-515358-25-00CTIS β
Skyrizi 600 mg concentrate for solution for infusion
Inflammatory Bowel Disease (IBD)
-
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β - 2024-515824-35-01CTIS β
Amoxicillin film-coated tablets for non-specific low back pain
non-specific low back pain
- 2024-515885-15-00CTIS β
10353
Patients with metastatic solid tumours, where clinical data has shown a rationale for ICI therapy.
- 2024-515900-38-00CTIS β
1/BOB1
B-cell Acute Lymphoblastic Leukemia, Multiple Myeloma, Non-Hodgkin B-cell lymphoma
-
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β - 2024-516260-29-00CTIS β
Irinotecan HCl-trihydraat Fresenius Kabi /ml
non-metastatic (borderline) resectable pancreatic cancer
-
CTIS β -
CTIS β - 2024-516279-34-00CTIS β
PaNaMa code: 113071
Pulmonary Hypertension, Coronary Microvascular Dysfunction, Hypoxia, Heart Failure
- 2024-516324-34-01CTIS β
SALINE, TRANEXAMIC ACID
Slipped capital femoral epiphysis (SCFE), Legg-CalvΓ©-Perthes Disease (LCPD), Neuromuscular conditions, Secondary hip dysplasia, Developmental dysplasia of the hip (DDH)
-
CTIS β -
CTIS β - 2024-516415-24-03CTIS β
Sugammadex hameln /ml oplossing voor injectie for General anesthesia
General anesthesia
- 2024-516427-13-00CTIS β
Placebo: PL1 for Posttraumatic Stress Disorder (PTSD)
Posttraumatic Stress Disorder (PTSD)
-
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β - 2024-516736-10-00CTIS β
KEYTRUDA 25 mg/mL concentrate for solution for infusion
Mismatch repair deficient endometrial cancer / uterine cancer
-
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β - 2024-516781-10-00CTIS β
An open label for High grade serous ovarian cancer
High grade serous ovarian cancer
- 2024-516788-96-00CTIS β
OXALIPLATIN, CAPECITABINE
Locally advanced or metastatic gastro-intestinal carcinoma
- 2024-516795-15-00CTIS β
202000570
Metastatic solid tumors, these may include but are not limited to melanoma, non-small-cell lung carcinoma (NSCLC), cervical cancer, microsatellite instable (MSI)-high/deficient mismatch repair (dMMR) cancer, renal cell carcinoma (RCC), CSCC, urothelial cell carcer (UCC), small cell lung cancer (SCLC) and head and neck squamous cell carcinoma (HNSCC).
-
CTIS β -
CTIS β -
CTIS β -
CTIS β - 2024-516940-24-00CTIS β
Bavencio 20 mg/mL concentrate for solution for infusion
locally advanced urothelial cancer.
-
CTIS β -
CTIS β -
CTIS β -
CTIS β - 2024-517176-38-00CTIS β
Idefirix 11 mg powder for concentrate for solution for infusion
neuromyelitis optica spectrum disorder, devic disease
-
CTIS β -
CTIS β - 2024-517258-85-00CTIS β
Optical PD-L1 imaging using Quantitative Fluo... for Esophageal cancer
Esophageal cancer
- 2024-517267-23-00CTIS β
BOTOX 100 Allergan Units Powder for Solution for Injection
postoperative pancreatic fistulas
- 2024-517381-42-00CTIS β
Safety of TEG001 in patients with r/r AML/high-risk MDS or r/r MM
Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS), Multiple Myeloma (MM)
- 2024-517485-42-00CTIS β
Ketanest-S 25 Multi-dose for Non-psychotic therapy resistantβ¦
Non-psychotic therapy resistant unipolar depression
-
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β - 2024-517782-16-00CTIS β
GEMCAD-1802
Colorectal cancer and metastatic disease limited to the liver with bad prognosis.
- 2024-517783-37-00CTIS β
Acetylsalicylzuur Aurobindo cardio for ST elevation myocardial infarctβ¦
ST elevation myocardial infarction (STEMI)
-
CTIS β - 2024-517865-17-01CTIS β
XELJANZ 11 mg prolonged-release tablets
Rheumatoid arthritis or psoriatic arthritis according to respectively 2010 criteria or CASPAR criteria
-
CTIS β -
CTIS β -
CTIS β - 2024-518041-16-00CTIS β
Fentanyl hameln 50 microgram/ml for healthy volunteers, opioid useβ¦
healthy volunteers, opioid use disorder
-
CTIS β -
CTIS β -
CTIS β - 2024-518215-18-00CTIS β
Nexviadyme 100 mg powder for concentrate for solution for infusion
Glycogen storage disease type II or acid maltase deficiency, Pompe disease
- 2024-518269-92-00CTIS β
Myozyme 50 mg powder for concentrate for solution for infusion
Pompe disease / glycogenosis type II / acid maltase deficiency
-
CTIS β - 2024-518355-36-01CTIS β
Evaluation of the Novel Therapeutic Hepatitis... for chronic Hepatitis B
chronic Hepatitis B
- 2024-518422-32-01CTIS β
Tecentriq 1 200 mg concentrate for solution for infusion
(Diffuse) Large B-cell Lymphoma
-
CTIS β -
CTIS β -
CTIS β -
CTIS β - 2024-518684-35-00CTIS β
Kineret 100 mg/0.67 ml solution for injection in pre-filled syringe.
autoimmune disorders, joint disorders synonym: Still's disease, systemic JIA
- 2024-518769-80-00CTIS β
NL6220204217
HAMLETT compares regular treatment guidelines for patients in remission after a first episode of psychosis, namely continuation with antipsychotic medication for at least one year, with early dose reduction/discontinuation.
-
CTIS β -
CTIS β -
CTIS β - 2024-518865-85-00CTIS β
5-(1-(2-[18F] fluoroethoxy))-[3-(6 for Alzheimers Disease, sporadic Ceβ¦
Alzheimers Disease, sporadic Cerebral Amyloid Angiopathy, Parkinson
-
CTIS β -
CTIS β - 2024-519194-19-00CTIS β
IDP-121 Concentrate for solution for infusion 3 mg/mL
Chronic lymphocytic leukemia (CLL), Any type of B-cell lymphomas, Multiple myeloma (MM)
- 2024-519207-10-00CTIS β
Ultomiris 300 mg/30 mL concentrate for solution for infusion
Paroxysmal nocturnal hemoglobinuria (PNH)
-
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β - 2024-520090-12-00CTIS β
Dual-Wavelength Quantitative Fluorescence End... for Esophageal cancer
Esophageal cancer
-
CTIS β -
CTIS β - 2024-520407-27-00CTIS β
Bitopertin, Matching Placebo
X-Linked Protoporphyria (XLP), Erythropoietic Protoporphyria (EPP)
-
CTIS β - 2025-520540-15-00CTIS β
Sodium Chloride 0.9% w/v Intravenous Infusion...
aneurysmal subarachnoid hemorrhage
-
CTIS β - 2025-520673-39-00CTIS β
Click-cleavable imaging in HER2-positive cancers (CleavHER trial).
HER2-positive tumors
-
CTIS β - 2025-520792-67-00CTIS β
DIDaC/ NVALT35
Patients with advanced, metastatic NSCLC that have not progressed on a standard of care immunotherapy regimen 6 months after initiation of first line treatment.
-
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β - 2025-521468-36-00CTIS β
Irinotecan Accord 20 mg/ml concentraat voor oplossing voor infusie
Gastric peritoneal metastases
-
CTIS β - 2025-521770-34-00CTIS β
AmBisome liposomale amfotericine B for Chronic pulmonary aspergillosis
Chronic pulmonary aspergillosis
-
CTIS β - 2025-521870-33-00CTIS β
Giapreza 2.5 mg/ml concentrate for solution for infusion
Liver cancer (primary or secondary)
- 2025-521902-17-00CTIS β
IDP-121 Concentrate for solution for infusion 3 mg/mL
Unresectable/metastatic Small cell Lung Cancer (SCLC)
-
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β -
CTIS β - 2025-523898-42-00CTIS β
VERDYE 5 mg/ml poeder voor oplossing voor injectie
Histologically confirmed solid malignancy (e.g., head and neck, gastrointestinal, hepatobiliary, breast, genitourinary, sarcoma)
- 2025-524045-27-00CTIS β
Late immunity following single immunization with GA2 sporozoites (GACHA)
Falciparum malaria
- 2025-524057-13-00CTIS β
AchilleS tendinoPathy treated with cortIcosteRoid injEctions.
Achilles tendinopathy
-
CTIS β -
CTIS β -
CTIS β - 2025-524876-43-00CTIS β
Kyprolis powder for relapsed/refractory multiple myβ¦
relapsed/refractory multiple myeloma
-
CTIS β -
CTIS β -
CTIS β -
CT.gov β -
CT.gov β -
CT.gov β -
CT.gov β -
CT.gov β -
CT.gov β -
CT.gov β -
CT.gov β -
CT.gov β -
CT.gov β - NCT06425796CT.gov β
Adiposity and Iron Requirements in Pregnancy (ADIPREG)
Iron Deficiency Anemia of Pregnancy
-
CT.gov β -
CT.gov β -
CT.gov β -
CT.gov β -
CT.gov β