Friday, July 10, 2026

Intelligence · Clinical pipeline

Rare disease · Phase III

Rare disease programs at Phase III — ClinicalTrials.gov pipeline intelligence.

Programs 8

Quick answer

Rare disease Phase III programs: NovaPharmaNews indexes 8 matching clinical development programs from ClinicalTrials.gov with sponsor, modality, and NCT cross-links.

Top sponsors

Pipeline programs

  1. 2021/ABM/01/00010

    Bial Portela & Companhia S.A.

    Rare and ultra-rare glomerulonephritis

    phase 3 small molecule active

    1 trial
  2. 2025-521093-34-00

    Pari Pharma GmbH

    rare disease

    phase 3 small molecule active

    1 trial
  3. AXS-05 (dextromethorphan and bupropion) oral tablets

    Axsome Therapeutics

    Major Depressive Disorder

    phase 3 small molecule completed

    1 trial
  4. AXS-05 (dextromethorphan-bupropion)

    Axsome Therapeutics

    Agitation in Patients With Dementia of the Alzheimer's Type

    phase 3 small molecule completed

    2 trials
  5. CROSSING

    AstraZeneca AB

    Eosinophilic esophagitis (EoE) is a rare, chronic inflammatory disorder triggered by an immune response to foods and aeroantigens and characterized by a combination of esophageal dysfunction and eosinophilic infiltration of the esophagus

    phase 3 small molecule active

    1 trial
  6. Infrared ray heat treatment

    The First People's Hospital of Lianyungang

    Liver Cirrhosis

    phase 3 other active

    1 trial
  7. Nomlabofusp, Placebo to Nomlabofusp

    Larimar Therapeutics

    Friedreich’s ataxia is the most common inherited ataxia in humans and results from a deficiency of the mitochondrial protein, FXN. Friedreich’s ataxia is a rare, progressive, multisystem disease with an incidence that is estimated to be 1:29,000, and a carrier frequency of ~1:85.

    phase 3 small molecule active

    1 trial
  8. RCAPHM18_0018

    ISTA Pharma Limited

    Hirschsprung's disease

    phase 3 small molecule active

    1 trial

Frequently asked questions

How many rare disease Phase III programs exist?

8 programs match both the therapeutic area and stage filters in our published index.